The San Francisco 49ers and Los Angeles Rams play on Sunday, Sept. 22, at SoFi Stadium in a game on the NFL Week 3 schedule .
Which team will win the Week 3 NFL game?
Check out these NFL Week 3 picks and NFL Week 3 predictions for the game, which can be seen at 1:25 p.m. MST on FOX ( stream with free trial from FUBO ).
The 49ers are a 7.5-point favorite over the Rams in NFL Week 3 odds for the game, courtesy of BetMGM Sportsbook .
San Francisco is -350 on the moneyline, while Los Angeles is +280.
The over/under (point total) is set at 45.5 points.
NFL Week 3 picks: Patriots vs Jets | Giants vs Browns | Bears vs Colts | Texans vs Vikings | Eagles vs Saints | Chargers vs Steelers | Broncos vs Buccaneers | Packers vs Titans | Panthers vs Raiders | Dolphins vs Seahawks | Lions vs Cardinals | Ravens vs Cowboys | 49ers vs Rams | Chiefs vs Falcons | Jaguars vs Bills | Commanders vs Bengals | The Arizona Republic's predictions
Watch 49ers at Rams live with FUBO (free trial)
Jeremy Cluff writes: "Both of these teams are coming off disappointing losses. The 49ers, even without Christian McCaffrey, were at least competitive."
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Bill Speros writes: "SoFi Stadium has become home turf for the 49ers. San Francisco is playing for keeps this season and desperately needs an NFC West win here. The 49ers covered 66% of the time as road favorites last season. Defense usually travels well - unless its facing Justin Jefferson. Here, it's only going 400 miles to another "home" site. We locked in the 49ers at -4.5 before Week 2. Normally, the over in Rams-49ers game would be a no-brainer. But the Rams could well be without WR Cooper Kupp (ankle), in addition to WR Puka Nacua, who has landed on IR. The 49ers are without Christian McCaffrey. A rock fight in Inglewood."
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The site's formula predicts that the 49ers will win the NFL Week 3 game against the Rams.
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ESPN : 49ers have a 64.3% chance to beat Rams on Sunday
The site gives the Rams a 35.5% shot at winning the NFL Week 3 game.
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Dimers : 49ers 25, Rams 22
It writes: "After extensive simulations, our model gives the 49ers a win probability of 61%, while the Rams have a win probability of 39%."
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com . Follow him on X, formerly Twitter @Jeremy_Cluff.
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This article originally appeared on Arizona Republic: San Francisco 49ers vs Los Angeles Rams picks, predictions: Who wins NFL Week 3 game?
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