Scientists at deCODE genetics, a subsidiary of AMGEN, have discovered rare sequence variants, predicted to cause a loss of function of ITSN1, that are associated with a high risk of Parkinson‘s Disease. The findings also support less studied pathways involved in the pathogenesis of the disease. The study, published...

deCODE genetics: Rare sequence variants, that associate with a high risk of Parkinson‘s Disease

Journal of Translational Medicine volume 22, Article number: 768 (2024) Cite this article. Postoperative liver metastasis significantly impacts the prognosis of pancreatic neuroendocrine tumor (panNET) patients after R0 resection. Combining computational pathology and deep learning radiomics can enhance the detection of postoperative liver metastasis in panNET patients. Methods. Clinical data,...

A novel model for predicting postoperative liver metastasis in R0 resected pancreatic neuroendocrine tumors: integrating computational pathology and deep learning-radiomics

Journal of Translational Medicine volume 22, Article number: 771 (2024) Cite this article. Stroke is a globally dangerous disease capable of causing irreversible neuronal damage with limited therapeutic options. Meldonium, an inhibitor of carnitine-dependent metabolism, is considered an anti-ischemic drug. However, the mechanisms through which meldonium improves ischemic injury and its potential to protect neurons remain largely unknown.

Meldonium, as a potential neuroprotective agent, promotes neuronal survival by protecting mitochondria in cerebral ischemia–reperfusion injury

BMC Psychiatry volume 24, Article number: 561 (2024) Cite this article. Self-absorption refers an excessive, persistent, and rigid preoccupation with information regarding the self. This study aims to introduce the Self-Absorption Scale (SAS) into China with an assessment of its latent variable structure, network structure, psychometric properties, and clinical utility in a nonclinical Chinese sample.

Structure, network analysis, psychometric properties and clinical utility of the self-absorption scale in China

Findings from a prespecified secondary analysis of the reduced-dose cohort of the TESTING trial suggest the efficacy of a lower dose of oral methylprednisolone in IgA nephropathy. A reduced-dose oral methylprednisolone regimen tapered over 6 to 9 months improves kidney outcomes in patients with high-risk IgA nephropathy (IgAN), according to...

Reduced-Dose Methylprednisolone Improves Kidney Outcomes, Delays Renal Failure in High-Risk IgAN

A multicenter, randomized, double-blind, placebo-controlled trial done performed in the the United Kingdom June 2014 to October 2017), enrolled 207 adult patients with symptomatic, radiographic KOA and knee pain (severity ≥4 out of 10) on most days in the past 3 months, after an inadequate response to analgesic medications.

Pain Reduction with Methotrexate in Knee Osteoarthritis

The following is a summary of “Derivation and validation of a machine learning model for the prevention of unplanned dialysis,” published in the May 2024 issue of Nephrology by Klamrowski et al. Half of all patients with advanced chronic kidney disease (CKD) progressing towards kidney failure start dialysis...

ML Models Accurately Predict Kidney Failure Risk and Unplanned Dialysis in Advanced CKD

Neurology News Network. for the week ending August 3, 2024. [WATCH TIME: 4 minutes]. Welcome to this special edition of Neurology News Network. I'm Marco Meglio. According to an announcement, the FDA has approved Alpha Cognition’s ALPHA-1062 (Zunveyl), a prodrug of an approved AChE inhibitor, galantamine, as a treatment for patients with mild-to-moderate Alzheimer disease (AD). ALPHA-1062, a delayed-release oral tablet formulation, is considered a new-generation AChEI inhibitor, with expected minimal gastrointestinal adverse events. The approval was based on results from 4 studies demonstrating the bioequivalence of ALPHA-1062 to galantamine and galantamine extended-release (ER). Across those studies, only 2% of treated patients had AEs from treatment, with no cases of insomnia observed. ALPHA-1062 is absorbed in the small intestine as an insert drug. Binding with AChE in the gastrointestinal nervous system is blocked by the addition of a benzyl ester to galantamine.

ALPHA-1062 Approved for Alzheimer Disease, GLP-1 Agonist Shows Neuroprotective Effects Against Dementia, Lecanemab 3-Year Data Reported

Blood tests that look for the anti-neutrophil cytoplasmic autoantibodies (ANCAs) that cause ANCA-associated vasculitis (AAV) may help identify patients with kidney involvement, a study shows. Still, ANCA testing was not as accurate for this purpose as a kidney biopsy, wherein a small piece of kidney tissue is collected for analysis.

ANCA blood tests may help detect kidney involvement: Study

During follow-up, 35% of patients died, according to the findings. Overall, 32% of deaths were linked to cardiovascular disease, 20% to dialysis withdrawal and 15% to infection. Patients who have diabetes at the time of kidney allograft loss may have a lower chance of survival compared with patients without diabetes,...

Patients with diabetes at time of kidney allograft loss may have lower survival

Community Voices represent independent, third-party users who have joined our contributor program but not yet verified their accounts. Community Voices are expected, like all users, to adhere to our Community Standards.

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NewsNinja

A lady is cautioning others about purchasing budget earrings from Amazon, Shein, and H&M, after she experienced keloid formations on her earlobes due to wearing them. On a TikTok post that has garnered more than 334,000 likes, Sailor Rozema (@sailor.rozema), a content creator, shares a warning with her community of "dangly earring girls": the inexpensive jewelry found in fast fashion can have negative impacts on your well-being.

‘I’ll never be wearing earrings for the rest of my life’: Customer warns against buying from Shein

The study was not adequately powered to assess a significant association with cancer mortalities. A new study has found a negative correlation between serum vitamin D and mortality in patients with gout and a U-shaped relationship in patients with hyperuricemia (HUA).1. “Though there are several major advances in gout treatment,...

Vitamin D Associated With Lower Risk of Mortality in Patients With Gout, Hyperuricemia

Secondary hypertension is when a person has high blood pressure due to another condition, such as kidney disease. Treating the underlying condition may reverse it. Genetic factors, diet, sedentary lifestyle, poor sleep, smoking, alcohol misuse, and obesity can cause primary hypertension. Secondary hypertension stems directly from another condition, such as...

What to know about secondary hypertension

Camden, NJ

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Cornelius, NC

Morristown Minute

CAMDEN, N.J. – Lisa Smith, 61, of Cornelius, North Carolina, has admitted to her role in a fraudulent scheme involving over $3.5 million in Paycheck Protection Program (PPP) loans. U.S. Attorney Philip R. Sellinger announced today that Smith pleaded guilty before U.S. District Judge Karen M. Williams in Camden federal court on July 17, 2024, to a charge of bank fraud conspiracy.

Woman Pleads Guilty to $3.5M COVID Relief Scam

Research on over 24,000 men revealed that low testosterone levels significantly increase the risks of death from all causes and cardiovascular issues, underlining the hormone’s impact on aging men’s health. A systematic review and meta-analysis revealed that men with low baseline levels of endogenous serum testosterone face a...

Low Testosterone in Men Linked to Increased Risk for Death

Las Vegas, NV

Bellingham Metro News

LAS VEGAS, NEVADA - A magnitude 4.4 earthquake struck areas near Las Vegas on Tuesday night, according to the United States Geological Service (USGS). The quake, which occurred at 8:06 p.m., was centered approximately 45 minutes from Las Vegas, near Indian Springs.

Magnitude 4.4 Earthquake Shakes Areas Near Las Vegas

Older adults with diabetes are at a higher risk of developing Alzheimer’s disease and other forms of dementia. New research suggests that blood sugar stability, measured by HbA1c time in range (TIR), might provide better insights into this risk than traditional HbA1c levels. The study found that veterans with...

Type 2 diabetes: Stable A1C levels may be linked to lower dementia risk

Thyroid lymphoma is an extremely rare but highly treatable cancer that affects the thyroid gland. It can cause a mass in the neck, difficulty swallowing, and shortness of breath. Most cases of thyroid cancer start when thyroid gland cells become cancerous. Thyroid lymphoma, meanwhile, is a disease that happens when...

What to Know About Thyroid Lymphoma

Journal of Translational Medicine volume 22, Article number: 767 (2024) Cite this article. Genetic epilepsy with febrile seizures plus (GEFS+) is a genetic epilepsy syndrome characterized by a marked hereditary tendency inherited as an autosomal dominant trait. Patients with GEFS+ may develop typical febrile seizures (FS), while generalized tonic–clonic seizures (GTCSs) with fever commonly occur between 3 months and 6 years of age, which is generally followed by febrile seizure plus (FS+), with or without absence seizures, focal seizures, or GTCSs. GEFS+ exhibits significant genetic heterogeneity, with polymerase chain reaction, exon sequencing, and single nucleotide polymorphism analyses all showing that the occurrence of GEFS+ is mainly related to mutations in the gamma-aminobutyric acid type A receptor gamma 2 subunit (GABRG2) gene. The most common mutations in GABRG2 are separated in large autosomal dominant families, but their pathogenesis remains unclear. The predominant types of GABRG2 mutations include missense (c.983A → T, c.245G → A, p.Met199Val), nonsense (R136*, Q390*, W429*), frameshift (c.1329delC, p.Val462fs*33, p.Pro59fs*12), point (P83S), and splice site (IVS6+2T → G) mutations. All of these mutations types can reduce the function of ion channels on the cell membrane; however, the degree and mechanism underlying these dysfunctions are different and could be linked to the main mechanism of epilepsy. The γ2 subunit plays a special role in receptor trafficking and is closely related to its structural specificity. This review focused on investigating the relationship between GEFS+ and GABRG2 mutation types in recent years, discussing novel aspects deemed to be great significance for clinically accurate diagnosis, anti-epileptic treatment strategies, and new drug development.

GABRG2 mutations in genetic epilepsy with febrile seizures plus: structure, roles, and molecular genetics

1. In a cohort of patients with mechanical heart valves and a prior history of intracranial hemorrhage (ICH), the risk of thromboembolism, ischemic stroke, and valve thrombosis was low following anticoagulation reversal therapy (PCC or FFP) 2. The timing of anticoagulation reinitiation was not associated with the risk of ICH...

Characterizing risk of stroke following anticoagulation reversal in patients with prior intracranial hemorrhage and heart valves

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Association between kidney function and Parkinson’s disease risk: a prospective study from the UK Biobank

BMC Public Health volume 24, Article number: 2225 (2024) Cite this article. Parkinson’s disease (PD) is a neurodegenerative influenced by various clinical factors. The potential relationship...

Association between kidney function and Parkinson’s disease risk: a prospective study from the UK Biobank

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