Columbus, OH

Journal of Translational Medicine volume 22, Article number: 768 (2024) Cite this article. Postoperative liver metastasis significantly impacts the prognosis of pancreatic neuroendocrine tumor (panNET) patients after R0 resection. Combining computational pathology and deep learning radiomics can enhance the detection of postoperative liver metastasis in panNET patients. Methods. Clinical data,...

A novel model for predicting postoperative liver metastasis in R0 resected pancreatic neuroendocrine tumors: integrating computational pathology and deep learning-radiomics

Journal of Translational Medicine volume 22, Article number: 769 (2024) Cite this article. Although immune checkpoint inhibitors (ICIs) have revolutionized the landscape of cancer treatment, only a minority of colorectal cancer (CRC) patients respond to them. Enhancing tumor immunogenicity by increasing major histocompatibility complex I (MHC-I) surface expression is a promising strategy to boost the antitumor efficacy of ICIs.

Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I

Genome Medicine volume 16, Article number: 101 (2024) Cite this article. The Alpe-DPD study (NCT02324452) demonstrated that prospective genotyping and dose-individualization using four alleles in DPYD (DPYD*2A/rs3918290, c.1236G > A/rs75017182, c.2846A > T/rs67376798 and c.1679 T > G/rs56038477) can mitigate the risk of severe fluoropyrimidine toxicity. However, this could not prevent all toxicities. The goal of this study was to identify additional genetic variants, both inside and outside DPYD, that may contribute to fluoropyrimidine toxicity.

Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD

shefinds

Supplements are often taken to improve health and fill nutritional gaps, but not all are as beneficial as they seem. Some supplements, particularly when taken in excess or without proper guidance, can have unintended negative effects. For example, certain supplements can unknowingly contribute to high blood pressure and increase the risk of cardiovascular events.

4 Worst Supplements That Could Actually Lead To High Blood Pressure And Cardiovascular Events: Licorice Root & More

Early-in-life exposure to a common toxic chemical found in some foods and in breastmilk may disrupt healthy bacteria in the gut and increase a person’s risk for developing various diseases later in life, according to a new animal study. The findings, published Aug. 14 in the journal Environmental Health...

Early exposure to toxic TCDF messes with gut bacteria later in life, finds study in mice

In the United States, approximately 47% of adults have hypertension, a condition characterized by consistently elevated blood pressure. This statistic is concerning as high blood pressure is a significant risk factor for serious health issues, including heart disease, stroke, and kidney disease. Elevated blood pressure often goes unnoticed due to its asymptomatic nature, earning it the nickname “the silent killer.” Health practitioners must prioritize blood pressure monitoring and management, as early detection and treatment can prevent complications and improve overall health outcomes. By addressing hypertension, practitioners can significantly reduce the burden of cardiovascular diseases and enhance the quality of life for their patients.

9 Effective Ways to Lower Blood Pressure Naturally

Although the overall use of benzodiazepines does not appear to increase the risk of dementia, long-term use is associated with a reduction in the volume of critical brain areas, such as the hippocampus and the amygdala, according to new research published in BMC Medicine. This finding supports current medical guidelines that caution against prolonged benzodiazepine use.

Long-term benzodiazepine use linked to shrinkage in two brain regions

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Sam Westreich, PhD

Can unique bacterial signatures help predict if you have cancerous tumors? Maybe not. Bacteria thrive in all sorts of unusual places. We all carry around trillions of them in our intestines, for example, creating a diverse community that is known as the gut microbiome.

A Revolutionary Microbiome Paper From 4 Years Ago Has Just Been Retracted

An anti-inflammatory diet reduced the risk of dementia by 31% in people even if they had type 2 diabetes, heart disease or stroke, according to a new study.

Eating these foods lowers dementia risk, even with type 2 diabetes and heart disease, study says

Research on over 24,000 men revealed that low testosterone levels significantly increase the risks of death from all causes and cardiovascular issues, underlining the hormone’s impact on aging men’s health. A systematic review and meta-analysis revealed that men with low baseline levels of endogenous serum testosterone face a...

Low Testosterone in Men Linked to Increased Risk for Death

Las Vegas, NV

Contributors represent independent, third-party users who have joined our contributor program and self-verified their accounts. They have also demonstrated their experience writing hard news for other outlets. Contributors are expected, like all users, to adhere to our Community Standards.

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Bellingham Metro News

LAS VEGAS, NEVADA - A magnitude 4.4 earthquake struck areas near Las Vegas on Tuesday night, according to the United States Geological Service (USGS). The quake, which occurred at 8:06 p.m., was centered approximately 45 minutes from Las Vegas, near Indian Springs.

Magnitude 4.4 Earthquake Shakes Areas Near Las Vegas

Colorado State

David Heitz

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

Health

Medically reviewed by Danielle Weiss, MDMedically reviewed by Danielle Weiss, MDCortisol belly is weight gain in the abdominal area, sometimes referred to as abdominal obesity, caused by an excess of the stress hormone cortisol. It can happen to anyone experiencing prolonged stress.Other factors can also contribute to fat accumulation in the abdomen. Abdominal obesity is common: approximately 53% of adults in the United States experience the condition, and it is more common in people with uteruses.Treatment for cortisol belly usually requires individuals to identify stressors and reduce them. Avoiding smoking, getting more sleep, and seeking mental health care can help.Cortisol...

What To Know About Cortisol Belly

A new meta-analysis has reported that individuals with a high triglyceride-glucose index have a 41% greater likelihood of suffering from depression compared to those with lower values of this index. These results remained consistent across individuals both above and below 50 years of age, as well as across different genders. The research was published in Frontiers in Psychiatry.

Individuals with high triglyceride-glucose index are more likely to suffer from depression

Medical News Today

According to recent research, semaglutide drugs, such as Ozempic and Wegovy, are linked to a lower risk of cognitive problems, as well as reduced cravings for nicotine.

Semaglutide linked to lower cognitive decline risk and reduced nicotine cravings

Scientists at deCODE genetics, a subsidiary of AMGEN, have discovered rare sequence variants, predicted to cause a loss of function of ITSN1, that are associated with a high risk of Parkinson‘s Disease. The findings also support less studied pathways involved in the pathogenesis of the disease. The study, published...

deCODE genetics: Rare sequence variants, that associate with a high risk of Parkinson‘s Disease

In a recent study, the investigational drug, PIPE-307, effectively induced OPC differentiation and remyelination in MS donor human brain tissue and an animal model and restored lost function in an MS mouse model. Multiple sclerosis (MS) is an autoimmune disease in which aberrant inflammatory processes cause destruction of the protective...

Potential First-in-Class M1R Antagonist May Promote Remyelination and Restore Function in Patients with MS

Athens, GA

WEDNESDAY, Aug. 14, 2024 (HealthDay News) — Fish oil seems to counteract genetic predisposition to high cholesterol, according to a study published online July 15 in the American Journal of Clinical Nutrition. Yitang Sun, Ph.D., from the Franklin College of Arts and Sciences at the University of Georgia in...

Fish Oil Supplements Counteract Genetic Predisposition to High Cholesterol

Among patients with fibromyalgia, there was a moderate negative correlation between vitamin D and physical functioning as well as between magnesium and stiffness. An exploratory study evaluating the link between specific micronutrients and the symptoms of fibromyalgia revealed vitamin D and magnesium played a role in physical function and stiffness among patients.1.

Vitamin D, Magnesium Deficiency Linked to Worse Fibromyalgia Symptoms

Cooking With Maryann

This recipe is sooo tasty! It truly is for garlic lovers! It involves sautéing onions and mushrooms in butter and oil until golden, then adding wine to reduce. Garlic, thyme, and parsley are stirred in for flavor, followed by seasoning with salt and pepper. The dish is garnished with additional parsley and served warm, making for a savory, aromatic side. Here's what you'll need to make it:

Garlic Mushrooms in Brown Butter Herb Sauce

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Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

Cardiovascular Diabetology volume 23, Article number: 299 (2024) Cite this article. Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome,...

Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

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