Columbus, OH

BMC Infectious Diseases volume 24, Article number: 893 (2024) Cite this article. The present study utilized network pharmacology to identify therapeutic targets and mechanisms of Rehmannia glutinosa in sepsis treatment. RNA-sequencing was conducted on peripheral blood samples collected from 23 sepsis patients and 10 healthy individuals. Subsequently, the RNA sequence data were analyzed for differential expression. Identification of active components and their putative targets was achieved through the HERB and SwissTarget Prediction databases, respectively. Functional enrichment analysis was performed using GO and KEGG pathways. Additionally, protein-protein interaction networks were constructed and survival analysis of key targets was conducted. Single-cell RNA sequencing provided cellular localization data, while molecular docking explored interactions with central targets. Results indicated significant involvement of identified targets in inflammation and Th17 cell differentiation. Survival analysis linked several targets with mortality rates, while molecular docking highlighted potential interactions between active components and specific targets, such as rehmaionoside a with ADAM17 and rehmapicrogenin with CD81. Molecular dynamics simulations confirmed the stability of these interactions, suggesting Rehmannia glutinosa’s role in modulating immune functions in sepsis.

Exploring the potential mechanisms of Rehmannia glutinosa in treating sepsis based on network pharmacology

Asundexian did not prevent stroke or systemic embolism vs. apixaban in patients with atrial fibrillation despite less bleeding. A larger dose may be needed for complete factor XI inhibition. Treatment of atrial fibrillation with asundexian, a novel factor XIa inhibitor, was associated with increased stroke and systemic embolism risk despite...

Asundexian did not prevent stroke, systemic embolism vs. apixaban in atrial fibrillation

Cancer Health

In 2006, Diana Lindsay, who had never so much as held a cigarette, was diagnosed with stage 4 lung cancer. It had metastasized to both lungs, her brain and lymph nodes. Keith Eaton, MD, PhD, clinical director of thoracic, head and neck medical oncology at Fred Hutch Cancer Center, told her that a typical patient in this situation would have about nine months to live. But he also observed that she seemed remarkably strong and vital. “He said, ‘You don’t look like my normal lung cancer patient,’” said Lindsay, who had just returned from a business trip to Europe. She was 54 at the time. “He didn’t want to take away the health I had for the limited time I had to live.”

20 Years Since an EGFR Discovery, a Woman With Stage IV Lung Cancer Is Thriving

Philadelphia, PA

Parade

Find out what dementia experts have to say about the connection.

A New Study Says This Commonly-Prescribed Medication Could Help Lower Dementia Risk By 50%

Treatment with an ARPI extended overall survival (OS), with a median OS of 38.7 months in the ARPI arm vs 21.7 months in the taxane arm and 21.8 months in the physician’s choice of treatment arm. Treatment with androgen receptor pathway inhibitors (ARPIs) led to an improved treatment response...

ARPIs achieve improved treatment response in patients with mCRPC and detectable ctDNA

Contributors represent independent, third-party users who have joined our contributor program and self-verified their accounts. They have also demonstrated their experience writing hard news for other outlets. Contributors are expected, like all users, to adhere to our Community Standards.

contributor

Alameda Post

Refined by New York chemist Robert Chesebrough almost 150 years ago, petroleum jelly is still widely used today in topical applications. Even with the myths that abound online about it being carcinogenic, it has withstood the test of time.

Wonder Jelly

Depressive disorders (DDs) are an independent risk factor for cardiovascular disease (CVD).1 In the United States, those with DDs are 3 times more likely to develop CVD than those without DDs, and CVD develops on average 7.5 years earlier than those without major depressive disorder (MDD).2 Although the cause-and-effect relationship between these 2 diseases is poorly understood, it is believed to be multifactorial and bidirectional. The lifetime prevalence of MDD in the US is 20.6% and continues to increase,3 making DDs a significant modifiable CVD risk factor that must be addressed. Screening and early treatment of DDs are just as important in preventing CVD as diabetes, obesity, hypertension, and smoking.

Early Detection of Depression Key to Halting Cardiovascular Disease

Writers represent independent, third-party users who have joined our contributor program and self-verified their accounts. Writers are expected, like all users, to adhere to our Community Standards.

writer

J. Souza

A man has sparked heated debate online after deciding to take a solo trip for his 40th birthday, despite his girlfriend's financial struggles. The man, who has been dating his girlfriend for three months, shared his dilemma on a popular Reddit forum.

Boyfriend Taking Vacation Alone Since Girlfriend Can't Afford It Asks if He's in the Wrong

Research at the European Society of Cardiology Congress 2024 evaluated lipid-lowering therapy beyond statins alone in patients with high levels of low-density lipoprotein cholesterol. While statins are commonly prescribed to lower low-density lipoprotein (LDL) cholesterol, and they can have other benefits for the heart, blood vessels, and other organs, not...

Lipid-Lowering Therapies Beyond Statins: ESC 2024

Marouf Alhalabi ORCID: orcid.org/0000-0001-5027-20961 & Soumar Mueen Alziadan ORCID: orcid.org/0009-0000-3099-99331. Virology Journal volume 21, Article number: 188 (2024) Cite this article. Metrics details. Abstract. Background. The role of cytomegalovirus infection as an opportunistic pathogen in exacerbating ulcerative colitis and its response to treatment remain a topic of ongoing debate. Clinicians...

A diagnostic dilemma: cytomegalovirus colitis as an uncommon comorbidity in inflammatory bowel disease: a case report

Neurocrine Biosciences has achieved late-stage success with muscarinic M4 selective agonist in schizophrenia. Results from a phase 2 trial of the candidate schizophrenia drug, currently known as NBI-1117568, show that it met the primary trial endpoint of a significant improvement in the Positive and Negative Syndrome Scale (PANSS) total score.

Neurocrine’s schizophrenia drug succeeds at phase 2, but dosing questions remain

Georgia State

DeanLand

Three earthquakes were recorded in Georgia during August, the strongest a 2.4 magnitude which occured far outside of the area where Georgia earthquakes most often occur. The quakes were recorded and reported by the US Geological Survey, which maintains seismograph stations throughout the US.

Rare SE Georgia Earthquake Recorded in August, State's Farthest South in 10 Years

New STEP-HFpEF findings presented at this year’s European Society of Cardiology Congress add to the many accolades this glucagon-like peptide-1 receptor agonist has already received for the numerous benefits it can produce among patients living with heart failure with preserved ejection fraction. Subanalyses presented in one of the first...

Semaglutide Enhances Heart Failure Outcomes in Obesity

BMC Public Health volume 24, Article number: 2371 (2024) Cite this article. Both body mass index (BMI) and genetic factors independently contribute to cardiovascular disease (CVD). However, it is unclear whether genetic risk modifies the association between BMI and the risk of incident CVD. This study aimed to investigate whether BMI categories and genetic risk jointly and interactively contribute to incident CVD events, including hypertension (HTN), atrial fibrillation (AF), coronary heart disease (CHD), stroke, and heart failure (HF).

Joint and interactive associations of body mass index and genetic factors with cardiovascular disease: a prospective study in UK Biobank

NXP800 was granted orphan drug designation from the FDA in ARID1a-deficient ovarian, fallopian tube, and primary peritoneal cancers. The FDA granted NXP800 orphan drug designation (ODD) for the potential treatment of patients with ARID1a-deficient ovarian, fallopian tube, and primary peritoneal cancers. NXP800 is a novel GCN2 kinase activator. The agent...

NXP800 Gains FDA Orphan Drug Status in ARID1a-Deficient Ovarian Cancers

ABA-101 has shown promising safety and anti-inflammatory effects in animal models, and Abata Therapeutics plans to initiate a Phase 1 study in 2024 to evaluate its potential for treating progressive multiple sclerosis. According to a recent announcement, the FDA has granted fast track designation to Abata Therapeutics’ autologous regulatory T...

FDA Fast Tracks Autologous Treg Therapy ABA-101 for Progressive Multiple Sclerosis

The Independent

 ’Gene silencers’ have shown promise in reducing heart attacks, strokes and deaths caused by a rare heart disease.The drug Vutrisiran, sold under the brand name Amvuttra, works by binding to, and stifling, messenger RNA (mRNA) to reduce a disease-causing protein called transthyretin.Researchers are hopeful the treatment – which is given as an injection – could become “the new standard of care” for patients with transthyretin amyloid cardiomyopathy (ATTR-CM).ATTR-CM happens when the faulty transthyretin proteins do not form correctly and build up in the heart’s main pumping chamber, making it more difficult to pump blood.The condition can be hereditary or...

Heart disease breakthrough as ‘gene silencer’ drug shows promise

These data suggest the necessity of caution when clinicians treat select patient groups with dupilumab for atopic dermatitis. The treatment of atopic dermatitis with dupilumab is associated with a relative risk increase of developing cutaneous t-cell lymphoma, according to new findings, and such risk is highest within the initial year of treatment and among adults.1.

Dupilumab for Eczema Linked to Risk Increase for Cutaneous T-Cell Lymphoma

This is the fifth installment of a 6-part series on the lifelong journey of polycystic ovary syndrome (PCOS) and the stops along the way that a female may face. In this installment, I will discuss PCOS and cardiovascular disease. Continuing the journey with polycystic ovarian syndrome (PCOS), the multitude of...

Polycystic Ovary Syndrome and Cardiovascular Disease

Apache Junction, AZ

Suzy Jacobson Cherry

When I studied Anthropology in college, I learned that teeth have been indicators of economic status just about forever. Archaeologists look at the teeth in ancient skeletons and know who the rich were based on their tooth decay. During the Renaissance period, it became fashionable for women to blacken their teeth to look like they were better off than they were, because the royals and aristocrats, who could afford sugar and sweets, had more rotten and missing teeth than the poor.

Opinion: Stop Stereotyping Bad Teeth as a Sign of Drug Addiction

NewsBreak

A case report of prolonged viral shedding of SARS-CoV-2 in a patient who receive ibrutinib for CLL therapy

BMC Infectious Diseases volume 24, Article number: 895 (2024) Cite this article. Patients on B cell immunosuppressive treatments have been shown to have persistent infection of...

A case report of prolonged viral shedding of SARS-CoV-2 in a patient who receive ibrutinib for CLL therapy

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