2024 Week 1 NFL picks, odds, best bets from proven model: This 5-way football parlay pays 25-1

The NFL returns with a thrilling Week 1 NFL schedule, featuring no double-digit favorites in the Week 1 NFL odds. The Bengals are 9-point favorites against New England in the Week 1 NFL betting lines, while every other game is a one-score spread. There are also three divisional matchups to choose from when crafting Week 1 NFL parlay picks. Which teams have the most value in the Week 1 NFL lines? Jim Harbaugh will lead the Chargers against the Raiders in an AFC West showdown. The Chargers are three-point favorites at home, but should you include Los Angeles in your Week 1 NFL bets? Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model .

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 185-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 39-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 1 NFL picks at SportsLine .

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Detroit Lions (-3.5) to cover at home against the Los Angeles Rams. The Lions were one of the toughest teams to beat at home last season. Detroit is 8-1 in its last nine home games and the Lions have had success against the Rams at Ford Field over the years.

In fact, Detroit is 4-1 in its last five home games against the Rams, which included a Wild Card Round playoff victory in January. Star wide receiver Amon-Ra St. Brown hauled in seven receptions for 110 yards in Detroit's victory, while running backs David Montgomery and Jahmyr Gibbs both recorded rushing touchdowns. SportsLine's model projects the Lions to score more than 30 points against Los Angeles in Week 1, a big reason why Detroit covers the spread in almost 60% of simulations. See which other NFL parlay picks to make here .

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home favorite that covers the spread in almost 70% of simulations. You can only see the model's NFL Week 1 best bets and parlay at SportsLine .

What are the model's top Week 1 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 185-129 run on top-rated picks , and find out.