2024 Week 1 NFL picks, odds, best bets from proven model: This five-way football parlay pays 25-1

The Week 1 NFL schedule has almost arrived, with the new NFL season kicking off Thursday, Sept. 5, when the Chiefs host the Ravens. Kansas City lost its season-opener to Detroit last season as a favorite and is a three-point favorite in the Week 1 NFL odds. The Chiefs are trying to avoid a letdown performance following another Super Bowl victory, while the Ravens are hoping to establish themselves as the top team in the AFC this year. Should you back either of those teams with your Week 1 NFL parlay picks?

All of the Week 1 NFL spreads are fewer than 10 points, as Cincinnati (-9 vs. New England) is the only team favored by at least one touchdown. With so many close games expected in Week 1, it is important to check out quality NFL betting advice for every game on the NFL odds board. Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model .

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 185-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 39-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 1 NFL picks at SportsLine .

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Detroit Lions (-3.5) to cover at home against the Los Angeles Rams. Detroit escaped with a 24-23 win over Los Angeles in a wild-card matchup last season, and it went on to beat Tampa Bay before losing to San Francisco in the NFC Championship. The Lions were among the most profitable teams in the league at the end of last season, covering the spread in six of their final seven games.

They went 8-1 in their final nine home games, and they will be playing in front of a rowdy crowd to open the 2024 campaign. Los Angeles has struggled in recent trips to Detroit, losing four of its last five games. The Rams lost three-time Defensive Player of the Year Aaron Donald to retirement in the offseason, which is one reason why the model has Detroit covering the spread in well over 50% of the latest simulations. See which other NFL parlay picks to make here .

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home favorite that covers the spread in almost 70% of simulations. You can only see the model's NFL Week 1 best bets and parlay at SportsLine .

What are the model's top Week 1 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 185-129 run on top-rated picks , and find out.