Duke vs. Northwestern prediction, odds, spread: 2024 college football picks, Week 2 bets from proven model

Northwestern is in the process of building a new football stadium but the Wildcats' temporary home is gaining high praise due to its scenicl views. Northwestern plays its second home game of the season on Friday when the Wildcats host the Duke Blue Devils at Northwestern Medicine Field at Martin Stadium. The stadium features a lakefront overview of Lake Michigan along with the Chicago skyline. Capacity is limited at roughly 15,000, but the stadium has generated excitement through the television, on social media and for those in attendance.

Kickoff is set for Friday at 9 p.m. ET. Northwestern is a 2-point favorite in the latest Northwestern vs. Duke odds according to the SportsLine consensus, with the over/under for total points scored is 37.5. Before making any Duke vs. Northwestern picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model .

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

Now, the model has set its sights on Northwestern vs. Duke and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model's picks . Here are the college football odds and betting lines for Duke vs. Northwestern:

• Duke vs. Northwestern spread: Northwestern -2
• Duke vs. Northwestern over/under: 37.5 points
• Duke vs. Northwestern money line: Northwestern -126, Duke +105
• Duke: The Blue Devils went 2-3 ATS on the road last season
• NW: The Wildcats are 3-7 in their last 10 games played on a Friday
• Duke vs. Northwestern picks: See picks at SportsLine

Why Duke can cover

The Blue Devils defeated Northwestern, 38-14, at home last season for their third victory over the Wildcats over the last three years. Duke has scored at least 30 points in each of those victories as even with changing personnel, the Blue Devils have dominated Northwestern in recent years. Duke is 5-0 against Northwestern since 2017 with two of those victories coming on the road.

Duke is becoming more than just a basketball school over recent years. The Blue Devils have finished with a winning record in back-to-back seasons for the first time since 2017 and 2018 and their 17 wins over the previous two seasons were the most since 2014 and 2015. Running back Jaquez Moore had 10 rushes for 61 yards and wide receiver Jordan Moore had five receptions for 56 yards against Northwestern last year and the two key playmakers are back this fall. The addition of Maalik Murphy , a sophomore quarterback who transferred from Texas , also provides big-play potential for a Duke offense that looks to continue its recent dominance over Northwestern. See which team to pick here .

Why Northwestern can cover

Northwestern forced two turnovers and held Miami (Ohio) to 40 rushing yards and 1.7 yards per carry last week. The Wildcats allowed just 4.1 yards per play in total, which ranked 23rd in college football after Week 1. Northwestern returned some top defensive talent from last year's surprising 8-5 outcome, including senior linebacker Xander Mueller , who had 102 tackles, and junior defensive lineman Aidan Hubbard , who had six sacks. The Wildcats held opponents to 10 points or fewer in four of 13 games last season while holding teams to fewer than 20 points six times as defense was the key reason for the team's successful season.

The start of last season was rough for Northwestern for reasons beyond the football field. Previous head coach Pat Fitzpatrick was fired in July 2023 after hazing allegations emerged, leaving Northwestern to quickly find his replacement. After a 4-5 start, Northwestern won its final four games, including a 14-7 victory over Utah in the Las Vegas Bowl as new head coach David Braun, who coached on the defensive side his entire career, cemented a defensive identity to the team. See which team to pick here .

How to make Northwestern vs. Duke picks

SportsLine's model is leaning Over on the total, projecting 41 combined points. The model also says one side of the spread hits well over 60% of the time. You can only get the model's pick at SportsLine .

So who wins Duke vs. Northwestern, and which side of the spread hits in well over 60% of simulations? Visit SportsLine now to see which side of the spread to jump on, all from the advanced computer simulation model that's up well over $2,000 on its college football picks since inception , and find out.