2024 Week 2 NFL picks, odds, best bets from advanced model: This 5-way football parlay pays 25-1

NFL fans are gearing up for a loaded Week 2 NFL schedule featuring several potential playoff previews. According to the latest Week 2 NFL betting lines, there are multiple NFL matchups oddsmakers consider to be a toss-up on Sunday. Among the closest NFL spreads is Rams vs. Cardinals . Arizona is favored by 1.5 points and the Cardinals are 9-3 in their last 12 games played in Week 2. Elsewhere on the Week 2 NFL odds board, Trevor Lawrence and the Jacksonville Jaguars are 3.5-point favorites at home against Deshaun Watson and the Cleveland Browns . Should your Week 2 NFL parlay picks include one of those NFL matchups today or should you look elsewhere for value? Before you make any Week 2 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model .

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2024 NFL season on an incredible 184-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 38-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 2 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 2 NFL picks at SportsLine .

Top Week 2 NFL picks

After simulating every game 10,000 times, the model is high on the Kansas City Chiefs (-6) to cover at home against the Cincinnati Bengals . The Bengals looked uneven offensively in their 16-10 defeat at home against the New England Patriots in Week 1. Quarterback Joe Burrow completed 21-of-29 passes, but finished with just 164 passing yards. As a team, Cincinnati rushed for only 70 yards.

Meanwhile, Patrick Mahomes and the Chiefs looked sharp in their victory over the Baltimore Ravens . Mahomes threw for 291 yards and a touchdown, while rookie wide receiver Xavier Worthy recorded two total touchdowns. Kansas City has won the last two meetings against the Bengals and the Chiefs are 4-1 against the spread in their past five games against an opponent from the AFC North. SportsLine's model projects that trend to continue on Sunday as the Chiefs score 30 points against Cincinnati, a big reason why Kansas City covers the spread in almost 60% of simulations. See which other NFL parlay picks to make here .

How to make Week 2 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a road favorite that covers the spread in almost 70% of simulations. You can only see the model's NFL Week 2 best bets and parlay at SportsLine .

What are the model's top Week 2 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 2 NFL best bets from a model on an 184-130 run on top-rated picks , and find out.