LSU vs. South Carolina odds, spread: 2024 college football picks, Week 3 predictions from proven model

The 16th-ranked LSU Tigers open their SEC schedule when they meet the South Carolina Gamecocks on Saturday at Williams-Brice Stadium in Columbia, S.C. After a season-opening loss to USC, LSU rebounded with a 44-21 win over Nicholls last week. South Carolina opened with a 23-19 win over Old Dominion before starting SEC play last Saturday with a 31-6 win over Kentucky. The Tigers tied for second place with Mississippi in the SEC West last year at 6-2 and were 10-3 overall. The Gamecocks tied with Kentucky and Florida at 3-5 in SEC East play and were 5-7 overall in 2023. There will be no divisions this season.

Kickoff is set for noon ET. LSU holds a 19-2-1 series edge, and has won the last seven meetings. The Tigers are 6.5-point favorites in the latest LSU vs. South Carolina odds via SportsLine consensus, while the over/under for total points scored is 48.5. Before making any LSU vs. South Carolina picks, check out the college football predictions from the SportsLine Projection Model. .

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread . It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns.

The model has set its sights on LSU vs. South Carolina . You can head to SportsLine to see its picks. Here are several college football betting lines for the spread , money line and over/under for the game:

• LSU vs. South Carolina spread: LSU -6.5
• LSU vs. South Carolina over/under: 49.5 points
• LSU vs. South Carolina money line: LSU -265, South Carolina +213
• LSU: The Tigers have hit the game total over in 11 of their last 13 games (+8.80 units)
• SC: The Gamecocks have hit the first-quarter money line in nine of their last 12 games (+11.40 units)
• LSU vs. South Carolina picks: See picks at SportsLine

Why you should back LSU

Junior quarterback Garrett Nussmeier is off to a solid start to his season. He has completed 57 of 76 passes (75%) for 610 yards and eight touchdowns. He has thrown one interception and has a rating of 174.5. In the win over Nicholls, he completed 27 of 37 passes for 302 yards and six touchdowns. In four seasons at LSU, Nussmeier has completed 63.1% of his passes for 2,330 yards and 19 touchdowns and a rating of 145.2.

Nussmeier's top target has been senior wide receiver Kyren Lacy. He has 12 catches for 159 yards (13.3 average), including a long of 32 yards, and four touchdowns. Lacy is in his third year with the Tigers after spending two seasons at Louisiana. Against Nicholls, he caught five passes for 65 yards (13.0 average) and three touchdowns. See which team to pick here .

Why you should back South Carolina

Redshirt freshman quarterback LaNorris Sellers leads the Gamecocks offense. In two starts, he has completed 21 of 38 passes (55.3%) for 273 yards, two touchdowns and one interception with a rating of 127.7. Sellers has also carried 29 times for 64 yards (2.2 average) and one touchdown. In limited action a year ago, he completed all four of his passes for 86 yards and two touchdowns, while rushing five times for 51 yards and a score.

Senior running back Raheim Sanders also helps power the offense. He has carried 37 times for 142 yards (3.8 average) and two touchdowns. In the win at Kentucky, he carried 13 times for 54 yards (4.2 average) and one TD. Sanders is in his first season with the Gamecocks after spending three years at Arkansas. For his career, he has rushed 435 times for 2,372 yards (5.5 average) and 19 touchdowns. See which team to pick here .

How to make LSU vs. South Carolina picks

SportsLine's model is leaning Over on the total, projecting 49 combined points. It also says one side of the spread hits more than 50% of the time. You can only get the pick at SportsLine. .

So who wins LSU vs. South Carolina, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the LSU vs. South Carolina spread to jump on, all from the advanced model that is up over $2,000 on its FBS college football picks since its inception, and find out.