2024 Week 3 NFL picks, odds, best bets from advanced model: This five-way football parlay pays 25-1

The Panthers have looked like the worst team in the NFL through the first two weeks of the season, coming nowhere close to covering the spread in losses to the Saints and Chargers. They will try to bounce back when they visit the Raiders on Sunday during the Week 3 NFL schedule. Las Vegas sprung the biggest upset of Week 2, taking down Baltimore as an 8.5-point road underdog. The Raiders are 5.5-point favorites in the Week 3 NFL odds, one of the largest NFL betting lines of the week.

The 49ers (-7.5 at Rams) and Bengals (-7.5 vs. Commanders) are favored by more than one touchdown in the Week 3 NFL spreads. Should you include any of those heavy favorites in your Week 3 NFL parlay picks? Before you make any Week 3 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 3 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 3 NFL picks at SportsLine .

Top Week 3 NFL picks

After simulating every game 10,000 times, the model is high on the Seattle Seahawks (-3.5) cover at home against the Miami Dolphins . Miami has been one of the most overvalued teams in the NFL dating back to the end of last season, failing to cover the spread in five consecutive games. The Dolphins could have trouble snapping that skid in a difficult environment on Sunday, especially since they are expected to be without starting quarterback Tua Tagovailoa (concussion).

Running backs Raheem Mostert (chest) and Jeff Wilson Jr. (oblique) are also banged-up, leaving Miami in a precarious situation. Seattle appears poised to take advantage of the ailing Dolphins, as the Seahawks are coming off back-to-back wins over the Broncos and Patriots. They have now won five of their last six games dating back to last season, and the model has them covering the spread in almost 60% of the latest simulations. See which other NFL parlay picks to make here.

How to make Week 3 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home underdog that covers the spread in well over 60% of simulations, defying oddsmakers everywhere. You can only see the model's NFL Week 3 best bets and parlay at SportsLine .

What are the model's top Week 3 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 3 NFL best bets from a model on an 187-130 run on top-rated picks , and find out.