2024 Week 4 NFL picks, odds, best bets from advanced model: This five-way football parlay pays out 25-1

The Cincinnati Bengals are off to an 0-3 start with two losses as touchdown favorites or more this season. However, oddsmakers are giving the Bengals the benefit of the doubt once again as they visit the Panthers on Sunday. Despite Carolina pulling off a 36-22 upset over the Raiders last week, the Panthers are 4.5-point home underdogs against the Bengals according to the latest Week 4 NFL odds. Both teams are 1-2 against the spread this season, so what gives in this Week 4 NFL matchup and which Week 4 NFL lines should be on your radar as you build your Week 4 NFL parlay picks? Before you make any Week 4 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 4 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 4 NFL picks at SportsLine .

Top Week 4 NFL picks

After simulating every game 10,000 times, the model is high on the Chicago Bears (-3, 40.5) to cover at home against the Los Angeles Rams. After investing heavily in their offense this offseason, the Bears haven't seen the results that they'd hoped on that side of the ball but the defense has helped keep things competitive by ranking top 10 in the NFL in points allowed and yards allowed.

Chicago has won six games in a row at home straight up and is 7-2 against the spread in its last nine meetings with the Rams at Soldier Field. Meanwhile, Los Angeles is still dealing with major injury issues. Puka Nacua (knee) and Cooper Kupp (ankle) are both out this week and multiple offensive linemen will also miss this weekend's action, which is a big reason why the model has the Bears covering in nearly 60% of simulations. See which other NFL parlay picks to make here.

How to make Week 4 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a road underdog that wins outright, defying oddsmakers everywhere. You can only see the model's NFL Week 4 best bets and parlay at SportsLine .

What are the model's top Week 4 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 4 NFL best bets from a model on an 187-130 run on top-rated picks , and find out.