Michigan State vs. Oregon odds, spread: 2024 college football picks, Week 6 predictions from proven model

The No. 6 Oregon Ducks (4-0) will return home for the first time since the opening week of September when they host the Michigan State Spartans (3-2) on Friday night. Oregon is coming off back-to-back blowout road wins against Oregon State and UCLA to move up in the rankings. Michigan State is trending in the opposite direction following losses to Boston College and No. 3 Ohio State. This is the first meeting between these teams since the 2018 Redbox Bowl, which ended in a 7-6 Oregon win.

Kickoff is set for 9 p.m. ET on Friday at Autzen Stadium. Oregon is favored by 24 points in the latest Oregon vs. Michigan State odds, while the over/under is 52.5 points, per SportsLine consensus. Before entering any Michigan State vs. Oregon picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread . It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen strong returns.

The model has set its sights on Michigan State vs. Oregon . You can head to SportsLine to see its picks . Here are several college football betting lines for the spread , money line and over/under for the game:

• Michigan State vs. Oregon spread: Oregon -23.5
• Michigan State vs. Oregon over/under: 52.5 points
• Michigan State vs. Oregon money line: Oregon -3125, Michigan State +1235
• Michigan State vs. Oregon picks: See picks here
• Michigan State vs. Oregon streaming: FuboTV (Try for free)

Why Oregon can cover

Oregon is coming off its most complete performance of the season, cruising to a 34-13 win over UCLA to remain unbeaten. The Ducks, who are 42-3 in their last 45 home games dating back to 2017, are eyeing their first Big Ten home win. Their defense held the Bruins without an offensive touchdown and limited them to just 172 yards of total offense.

Senior quarterback Dillon Gabriel has completed 81.5% of his passes for 1,192 yards and nine touchdowns, while junior running back Jordan James has 64 carries for 386 yards. They are facing a Michigan State defense that was shredded by Ohio State last week in a 38-7 loss. This is a brutal travel spot for the Spartans following that blowout loss, and Oregon's fan base will be excited to return to Autzen Stadium. See which team to pick here.

Why Michigan State can cover

Michigan State is coming off a blowout loss, but it had covered the spread in two of its previous three games. The Spartans beat Maryland as 8-point road underdogs in early September and played Boston College close on the road two weeks ago. Head coach Jonathan Smith, who previously led Oregon State, took down then-No. 10 Oregon in 2022 with the Beavers.

The Spartans have turned the ball over 13 times in their first five games, so cleaning up those mistakes will lead to a competitive outing on Friday. Sophomore quarterback Aidan Chiles has 1,058 passing yards and five touchdowns, while senior running back Kay'ron Lynch-Adams has 306 rushing yards and a score. The Spartans are 13-1 in their last 14 Friday games. See which team to pick here.

How to make Oregon vs. Michigan State picks

The model has simulated Michigan State vs. Oregon 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations. You can only see the pick at SportsLine .

So who wins Oregon vs. Michigan State, and which side of the spread is hitting nearly 60% of the time? Visit SportsLine now to see which side of the Michigan State vs. Oregon spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception , and find out.