Alabama vs. Vanderbilt odds, spread, line: 2024 college football picks, Week 6 predictions from proven model

The No. 1 Alabama Crimson Tide (4-0) will go on the road for the second time this season when they face the Vanderbilt Commodores (2-2) on Saturday afternoon. Alabama is coming off a win in the biggest game of the college football season, taking down then-No. 2 Georgia in a 41-34 thriller. The Crimson Tide have won their last 23 games against Vanderbilt, with the last three coming by at least 34 points. Vanderbilt is on a two-game losing streak, but it pushed then-No. 7 Missouri to double overtime its last time out.

Kickoff is set for 4:15 p.m. ET on Saturday at FirstBank Stadium. Alabama is favored by 22.5 points in the latest Vanderbilt vs. Alabama odds, while the over/under is 54 points, per SportsLine consensus. Before entering any Alabama vs. Vanderbilt picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread . It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen strong returns.

The model has set its sights on Alabama vs. Vanderbilt . You can head to SportsLine to see its picks. Here are several college football betting lines for the spread , money line and over/under in the Vanderbilt vs. Alabama game:

• Alabama vs. Vanderbilt spread: Alabama -22.5
• Alabama vs. Vanderbilt over/under: 54 points
• Alabama vs. Vanderbilt money line: Alabama -2083, Vanderbilt +1013
• Alabama vs. Vanderbilt picks: See picks here
• Alabama vs. Vanderbilt streaming: FuboTV (Try for free)

Why Vanderbilt can cover

Vanderbilt is on a two-game losing streak, but it is coming off an impressive showing against then-No. 7 Missouri. The Commodores were 18-point underdogs in that game, but they were able to push Missouri to double overtime. Senior quarterback Diego Pavia had 178 passing yards and two touchdowns while rushing for a team-high 90 yards.

Pavia has 721 passing yards, six touchdowns and zero interceptions overall this season. He is a very difficult quarterback for opposing defenses to slow down, as he also leads Vanderbilt with 279 rushing yards. The Commodores have covered the spread in four of their last five games. See which team to pick here.

Why Alabama can cover

Alabama opened the season with three straight blowout wins prior to its thrilling win over Georgia last week. The Crimson Tide let a 28-point lead slip away before scoring the game-winning touchdown with less than three minutes remaining. Junior quarterback Jalen Milroe is the new Heisman favorite after completing 27 of 33 passes for 374 yards and two touchdowns.

Milroe led Alabama with 16 carries for 117 yards and two touchdowns as well, averaging 7.3 yards per carry. Freshman wide receiver Ryan Williams continued his impressive start to the season, catching six passes for 177 yards and the game-winning score. The Crimson Tide have covered the spread in 11 of their last 15 games, and they have covered in four of their last five games against Vanderbilt. See which team to pick here.

How to make Vanderbilt vs. Alabama picks

The model has simulated Alabama vs. Vanderbilt 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations. You can only see the pick at SportsLine.

So who wins Vanderbilt vs. Alabama, and which side of the spread is hitting nearly 60% of the time? Visit SportsLine now to see which side of the Alabama vs. Vanderbilt spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception , and find out.