Iowa State vs. Baylor odds, spread, time: 2024 college football picks, Week 6 predictions from proven model

The Baylor Bears (2-3) will try to snap their two-game losing streak when they go on the road to face the No. 16 Iowa State Cyclones (4-0) on Saturday night. Baylor lost to Colorado and then-No. 22 BYU by one score each, putting the Bears in a tie for last place in the Big 12 standings. Iowa State opened conference play with a 20-0 win at Houston last week, holding a fourth straight opponent under 20 points to open the season. The Cyclones notched a 30-18 road win last year, but Baylor has won six of the last 10 meetings.

Kickoff is set for 7:30 p.m. ET on Saturday at Jack Trice Stadium. Iowa State is favored by 13 points in the latest Iowa State vs. Baylor odds, while the over/under is 45 points, per SportsLine consensus. Before entering any Baylor vs. Iowa State picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread . It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen strong returns.

The model has set its sights on Baylor vs. Iowa State . You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

• Iowa State vs. Baylor spread: Iowa State -13
• Iowa State vs. Baylor over/under: 45 points
• Iowa State vs. Baylor money line: Iowa State -529, Baylor +386
• Iowa State vs. Baylor picks: See picks here
• Iowa State vs. Baylor streaming: FuboTV (Try for free)

Why Iowa State can cover

Iowa State has continued to move up the rankings after winning all four of its games to open the season. The Cyclones were dominant on both sides of the ball last week, notching a 20-0 win at Houston. Sophomore running back Abu Sama III had 11 carries for 101 yards and a touchdown, while senior Jaylon Jackson finished with 96 yards.

The Cyclones will be playing in front of a "white out" crowd as they try to improve to 5-0 for the first time since 1980. They have outscored opponents 113-29 this season, as their defense ranks fourth in college football with just 7.3 points allowed per game. Iowa State has covered the spread in eight of its last 12 games, while Baylor is on a 12-game losing skid against Big 12 opponents. See which team to pick here.

Why Baylor can cover

Iowa State does not have a particularly explosive offense, finishing with 21 points or less in three of its four games. The Cyclones prefer to control the clock and play methodically, which will make it difficult to cover the two-touchdown spread. Baylor has scored at least 28 points in four of its first five games, narrowly losing to then-No. 22 BYU last week.

Junior quarterback Sawyer Robertson completed 27 of 48 passes for 324 yards and three touchdowns against the Cougars. He has rushed for 116 yards and three touchdowns this season, as one of five Baylor players who have gone over the 100-yard rushing mark. Baylor has covered the spread in five of the last six meetings between these teams. See which team to pick here.

How to make Iowa State vs. Baylor picks

The model has simulated Baylor vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits well over 50% of the time. You can only see the pick at SportsLine.

So who wins Iowa State vs. Baylor, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Baylor vs. Iowa State spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception , and find out.