NFL odds, Vegas lines, picks, spreads, game predictions: Model loves Falcons, Commanders in Week 6, 2024

If a rest advantage matters when making Week 6 NFL bets, then Buccaneers vs. Saints should stick out. Not only is New Orleans coming off a short week after playing on Monday night, but Tampa is also coming off extended rest after playing last Thursday. Since taking over as Saints coach in 2022, New Orleans is 2-4 straight-up and 1-5 against the spread at a rest disadvantage. That could make the Buccaneers tempting in Week 6 NFL picks.

The other team coming off a Thursday contest, Atlanta, will travel to Carolina, where the Falcons are six-point road favorites, per the Week 6 NFL spreads. Knowing how teams perform with more or less rest than their opponents could give you a leg up with your Week 6 NFL picks. All of the Week 6 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 6 NFL picks now .

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2024 NFL season on an incredible 10-2 hot streak on top-rated NFL picks this year. Longer term, it is on a 191-131 roll on top-rated NFL picks that dates back to the 2017 season and a 45-23 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 6 NFL odds and NFL betting lines on the spread , money line , and over-under , and locked in picks for every NFL matchup. Head here to see every pick .

Top Week 6 NFL predictions

We can tell you one of the model's strongest Week 6 NFL picks is that the Falcons (-6, 47.5) cover the spread versus the Panthers . The Falcons are coming off a mini-bye after playing last Thursday, and they've won back-to-back games. That Thursday contest saw Kirk Cousins set a franchise record with 509 passing yards, to go along with four passing touchdowns versus a Buccaneers team which had allowed just one passing TD on the season prior to that. Now, he gets to face a Panthers team which allowed the most passing TDs (11) in the NFL.

That's not the only thing that Carolina has allowed more of than any other team, as the squad has also given up the most points this season, and that's by a wide margin as it has allowed 20 more points than any other team. The Panthers have scored fewer points in every successive start by Andy Dalton and put just 10 points up against Chicago on Sunday. The state of bliss that Carolina had when Dalton took over and led it to a victory in his first start is clearly over, as the model has Atlanta (-5.5) covering well over 50% of the time. See which other teams to pick here .

Another one of its Week 6 NFL betting predictions: the Commanders (+6.5, 52.5) cover on the road versus the Ravens . Only the undefeated Vikings and Chiefs have longer winning streaks than Washington's four straight victories, and they've covered in each of those four as well. Its last two victories have both come by at least 21 points, while the team ranks second in the league with 31 points per game.

That potent offense should provide a problem for a Ravens defense which has uncharacteristically struggled. After leading the NFL in scoring defense a year ago, Baltimore ranks just 26th this year, giving up nearly 10 more ppg than in 2023. Joe Burrow just tossed five TD passes against Baltimore, which has allowed the second-most passing yards this season. With Jayden Daniels ' 77.1 CMP% leading the NFL, he should be able to dice up the Ravens defense. The SportsLine model has the Commanders (+6.5) covering well over 50% of the time, while the Over (52) also hits in well over 50% of simulations. See which other teams to pick here .

How to make Week 6 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 6 NFL schedule and just revealed two underdogs that outright win, potentially giving you a huge payday. You can only get every pick for every game at SportsLine .

So what NFL picks can you make with confidence, and which two must-see underdogs should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000 , and find out.

Week 6 NFL betting odds, lines, spreads

Get Week 6 NFL picks at SportsLine

Thursday, Oct. 10

49ers at Seahawks (+3.5, 47.5)

Sunday, Oct. 13

Jaguars vs. Bears -- in London (-2.5, 44.5)

Commanders at Ravens (-6.5, 52.5)

Cardinals at Packers (-5.5, 49.5)

Texans at Patriots (+7, 37.5)

Buccaneers at Saints (+2.5, 42)

Browns at Eagles (-8.5, 43.5)

Colts at Titans (+1, 43.5)

Chargers at Broncos (+3, 35.5)

Steelers at Raiders (+3, 36.5)

Falcons at Panthers (+6, 47.5)

Lions at Cowboys (+3, 52.5)

Bengals at Giants (+3.5, 48.5)

Monday, Oct. 14

Bills at Jets (+2.5, 41)