Lions vs. Cowboys prediction, odds, picks, line, spread, time: 2024 NFL picks, Week 6 bets from proven model

The NFL Week 6 schedule features a matchup between the Dallas Cowboys (3-2) and Detroit Lions (3-1) that could have a significant impact on the NFC playoff picture. The Cowboys have won back-to-back games, and are coming off a 20-17 win over the Pittsburgh Steelers on Sunday Night Football. The Lions had a bye in Week 5 and defeated the Seattle Seahawks 42-29 on Monday Night Football in Week 4. Detroit is 3-1, while Dallas is 2-3 against the spread this season. These teams met in 2023, with the Cowboys winning 20-19.

Kickoff at AT&T Stadium in Arlington is at 4:25 p.m. ET. Detroit is favored by 3 points in the latest Cowboys vs. Lions odds from SportsLine consensus, and the over/under is 52.5 points. Before locking in any Lions vs. Cowboys picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine .

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2024 NFL season on an incredible 10-2 hot streak on top-rated NFL picks this year. Longer term, it is on a 191-131 roll on top-rated NFL picks that dates back to the 2017 season and a 45-23 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model has set its sights on Lions vs. Cowboys and just locked in its picks and Week 6 predictions. You can head to SportsLine now to see the model's picks . Here are several NFL odds and betting lines for the spread , money line and over/under :

• Cowboys vs. Lions spread: Lions -3
• Cowboys vs. Lions over/under: 52.5 points
• Cowboys vs. Lions money line: Lions -173, Cowboys +146
• Cowboys vs. Lions picks: See picks at SportsLine
• Cowboys vs. Lions streaming: FuboTV (try for free)
  

Why the Cowboys can cover

The Cowboys showed some resiliency in their Week 6 win over the Pittsburgh Steelers. Quarterback Dak Prescott looked especially sharp while leading the Cowboys' game-winning drive. The Cowboys were down by four with under five minutes left when they drove 75 yards for the winning score. Prescott hit Jalen Tolbert from four yards out for the game-winning touchdown.

Prescott threw for 352 yards and two touchdowns against an elite Steelers defense. For the season, the former fourth-round pick has 1,424 passing yards, eight touchdown passes and four interceptions. Prescott's top target remains All-Pro wide receiver CeeDee Lamb . The former Oklahoma star has yet to go over 100 receiving yards this season, but is on track to go over 1,000 receiving yards for the fourth straight season. See which team to pick here .

Why the Lions can cover

Detroit has been strong against the spread this season, posting a 3-1 record against the number entering Week 6. The Lions are favored in this matchup and covered the spread in their only other game as a road favorite this season. Detroit was 14-6 against the spread in 2023.

The Lions have one of the NFL's most explosive offenses. Quarterback Jared Goff (1,015 yards, five touchdowns, four interceptions) leads the way. His top targets are wide receivers Amon-Ra St. Brown (27 catches, 252 yards, two touchdowns) and Jameson Williams (13 catches, 289 yards, two touchdowns), and tight end Sam LaPorta (12 catches, 147 yards). Running backs Jahmyr Gibbs (285 yards, three touchdowns) and David Montgomery (271 yards and four touchdowns) are both on pace to go over 1,000 yards this season. See which team to pick here .

How to make Cowboys vs. Lions picks

The model has simulated Cowboys vs. Lions 10,000 times and the results are in. The model is leaning Over on the point total, and it's also generated a point-spread pick that hits in over 50% of computer simulations. You can only see the model's pick at SportsLine .

So who wins Lions vs. Cowboys in Week 6, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the Cowboys vs. Lions spread to back, all from the model that has returned well over $7,000 on top-rated NFL picks , and find out.