2024 Week 6 NFL picks, odds, best bets from advanced model: This five-way football parlay would pay out 25-1

The Atlanta Falcons and Tampa Bay Buccaneers are both 3-2, but the Falcons own the tiebreaker after a 36-30 win in overtime last week. Now, both squads will have divisional matchups again, with the Buccaneers visiting the Saints on Sunday and the Falcons visiting the Panthers. The latest Week 6 NFL odds list Tampa Bay as a 3.5-point road favorite, while Atlanta is favored by six in Carolina, up from an open of three. Which side should you favor in those two NFC South matchups and which NFL picks should you add to your Week 6 NFL parlay picks? Before you make any Week 6 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2024 NFL season on an incredible 10-2 hot streak on top-rated NFL picks this year. Longer term, it is on a 191-131 roll on top-rated NFL picks that dates back to the 2017 season and a 45-23 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 6 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 6 NFL picks at SportsLine .

Top Week 6 NFL picks

After simulating every game 10,000 times, the model is high on the Green Bay Packers (-5.5, 47.5) to cover at home against the Arizona Cardinals . Despite Jordan Love being on the shelf for two weeks with a knee injury, Green Bay is 3-2 on the season and ranks top 10 in the NFL in scoring, total yards, passing yards and rushing yards through five weeks.

Meanwhile, the Green Bay defense has forced a league-leading 14 turnovers and offseason signing Xavier McKinney has an interception in all five games. The Cardinals are 26th in EPA per play allowed, 29th in net yards per pass allowed, 23rd in opponent passer ranking, and 30th in third-down defense. With the Packers getting Romeo Doubs back, the model has Green Bay taking advantage of a leaky Arizona defense and covering in over 60% of simulations. See which other NFL parlay picks to make here .

How to make Week 6 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including two underdogs that win outright, defying oddsmakers everywhere. You can only see the model's NFL Week 6 best bets and parlay at SportsLine .

What are the model's top Week 6 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 6 NFL best bets from a model on an 191-131 run on top-rated picks , and find out.