Self-learning AI reveals NFL against the spread, over-under, money-line picks for every Week 6, 2024 game

The Houston Texans will face a rookie quarterback for the second time this season when they visit the New England Patriots during the Week 6 NFL schedule. Houston shut down Bears rookie quarterback Caleb Williams in Week 2, as he finished with just 174 passing yards and two interceptions while being sacked seven times. New England is giving No. 3 overall draft pick Drake Maye an opportunity to make the first start of his career, and the Texans are 6.5-point road favorites in the Week 6 NFL odds. Houston is 0-7 all time on the road against the Patriots, so should you back New England to cover with your Week 6 NFL predictions?

Sunday also brings matchups like the Ravens (-6.5, 51.5) vs. Commanders and Cowboys (+3, 52.5) vs. Lions. There are six Week 6 NFL spreads that are three points or smaller, while Philadelphia (-8.5 vs. Cleveland) is the only team favored by more than a touchdown in the Week 6 NFL lines, up 5.5 from the opener. Before you make any Week 6 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI .

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score.

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has nailed 128 4-star picks or better this season and hit a whopping 1,674 4.5- and 5-star prop picks last season. Anyone who has followed it is way up.

For Week 6 NFL betting , the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 14 games. You can only see the AI predictions for the Week 6 NFL schedule here .

Top Week 6 NFL AI picks

After analyzing every game in Week 6, the AI PickBot says the Broncos cover as 3-point home underdogs against the Chargers in  a game with the lowest over-under of the week, 35.5. Mile High has not been an inviting place for the Chargers over the past decade, losing seven of their last 10 games in Denver. They are on a two-game losing streak and have not scored a touchdown in the second half since Week 1.

It is going to be difficult for Los Angeles to get back on track against a Denver defense that is allowing the second-fewest points per game (14.6) in the NFL. Broncos rookie quarterback Bo Nix has not thrown an interception during the team's three-game winning streak, and Denver has won outright each of the past three times that the Chargers were road favorites in this rivalry. The AI PickBot is predicting another outright win for the Broncos, pointing to plenty of value on the home underdogs. See its other Week 6 football predictions and football picks at SportsLine.

How to make Week 6 NFL picks

In addition, the AI PickBot has generated 14 other A-rated picks for Week 6, including two with a coveted A+ grade. You need to see the AI PickBot's NFL picks before making any Week 6 NFL bets of your own. You can only see them at SportsLine .

Who wins and covers each Week 6 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that has nailed 128 top-rated picks this season .