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  • Dr Mehmet Yildiz

    What I Learned About 7 Bone Disorders and Enhanced My Musculoskeletal Health

    2024-01-07


    With over 1.7 billion worldwide impacted by musculoskeletal issues, our active involvement in bone health becomes a pressing societal imperative.


    This post includes a summary of my research into bone disorders to give you a high level perspective in simple language. This article does not include health advice. My goal is to inform you and create awareness as bone health is crucial as we age.

    According to WHO, “approximately 1.71 billion people have musculoskeletal conditions worldwide. These conditions refer to the performance of the locomotor system, comprising intact muscles, bones, joints, and adjacent connective tissues. Musculoskeletal impairments comprise more than 150 different diseases/conditions that affect the system.”

    As a bone disease, osteoporosis causes over 8.9 million fractures annually, resulting in an osteoporosis fracture every 3 seconds. It affects approximately 6.3% of men over 50 and 21.2% of women over the same age range globally.

    Based on the world population of men and women, this suggests that approximately 500 million men and women worldwide may be affected. You may check the staggering stats in this report from the Osteoporosis Foundation.

    When I wrote about osteoporosis last year to inform my readers about age-related diseases, I also mentioned other conditions like osteopenia, scoliosis, primary hyperparathyroidism, osteomalacia, renal osteodystrophy, and Paget bone disease. Some readers want to know more about these conditions, especially their symptoms, causes, treatment methods, and associated lifestyle factors to prevent them from occurring.

    I am not a bone specialist, but I am intensely interested in bone health; therefore, I research this topic for personal reasons and to inform my clients and readers interested in health, fitness, and well-being topics. This story does not include medical advice but covers my research and personal experiences to improve my bone health proactively.

    Wearing my researcher hat, I provide helpful information about bone health and diseases based on my literature review from reliable sources. However, treatment approaches may vary based on individual cases, and consulting healthcare professionals is crucial for accurate diagnosis and management.

    As a technologist, I introduce relevant technologies contributing to bone health, diagnosis, and treatment methods for awareness.

    Investing in bone health through healthy lifestyle choices and awareness about bone-related disorders can significantly reduce bone disease burden and improve our quality of life.

    To enhance clarity and credibility, I ensure that scientific sources are provided at the end of the story, addressing the request of my devoted readers. Catering to an audience that includes aspiring scientists, I provide pertinent research materials, aiding their exploration and facilitating easier access to relevant studies.

    This approach fosters transparency and elevates the discourse by offering relevant and credible sources, aligning with my commitment to providing authoritative and informative content to enthusiasts and professionals in the field.

    The National Library of Medicine (Pubmed) has indexed 792,440 medical reports on the bone disease since 1828. The surge in research, clinical, and review papers, limited to English resources, illustrates a significant escalation in focus and scholarly efforts dedicated to bone disease in recent decades. Considering reports in other languages would likely further emphasize the extensive global attention and research intensity on this health condition.

    After this brief background, I’d like to highlight the importance of bone health for everyone.

    Why is bone health vital?

    Maintaining optimal bone health is vital for avoiding fractures. It is crucial for maintaining an active lifestyle, preserving independence, reducing healthcare costs, and enhancing overall well-being across all age groups. Here are six compelling reasons to improve bone health.

    1 — Supports Mobility and Functionality

    Healthy bones provide structural support, enabling movement, balance, and physical functionality. Poor bone health can lead to fractures, reducing mobility and adversely affecting independence.

    2 — Prevents Fractures and Disabilities

    Strong bones are resistant to fractures. Weak bones, as seen in osteoporosis or osteopenia, significantly increase the risk of fractures, leading to disabilities and reduced quality of life.

    3 — Affects Quality of Life and Longevity

    Studies show that hip fractures are associated with increased mortality rates, especially in the elderly population. Fractures, particularly hip fractures, can have severe health consequences, including decreased life expectancy and compromised quality of life due to pain, immobility, and complications.

    4 — Aging Population and Bone Health

    With an aging global population, the prevalence of bone-related disorders is expected to rise significantly. Age-related bone loss is a common concern, highlighting the need for preventive measures and early interventions to maintain bone health and prevent complications.

    5 — Lifestyle Impact

    Lifestyle factors like sedentary habits, smoking, excessive alcohol consumption, and poor nutrition negatively affect bone health, emphasizing the importance of a healthy lifestyle for solid bones.

    6 — Economic Burden

    Fractures and bone-related complications impose high healthcare costs, including hospitalizations, rehabilitation, and long-term care, impacting healthcare systems and economies. The economic burden of osteoporosis-related fractures is substantial. The IOF estimates the cost of fractures globally at $131.5 billion annually.

    An Overview of 7 Bone Disorders

    1. Osteoporosis

    Weakened bones characterize osteoporosis due to decreased bone density and quality, making them fragile and susceptible to fractures.

    It is often asymptomatic until a fracture occurs. Common sites for fractures include the hip, spine, and wrist.
    Hormonal changes (especially in postmenopausal women), inadequate calcium or vitamin D intake, lack of exercise, and certain medications contribute to its development.
    Improvement methods include calcium-rich foods and vitamin D supplements, regular weight-bearing exercises, medications like bisphosphonates, hormone replacement therapy (in some cases), and lifestyle modifications.
    Treatment methods from a medical angle include drugs and therapies with Bisphosphonates (alendronate or risedronate), selective estrogen receptor modulators, denosumab, teriparatide, and calcitonin are commonly prescribed medications.

    2. Osteopenia

    Osteopenia is a precursor to osteoporosis and is characterized by lower-than-normal bone density but not low enough to be classified as osteoporosis.

    Osteopenia is usually asymptomatic until bone fractures occur.
    Like osteoporosis, it involves aging, hormonal changes, inadequate nutrition, and lack of exercise.
    Similar to osteoporosis management, focusing on improving bone density through lifestyle changes and, in some cases, medication are standard treatment methods.

    3. Osteomalacia

    Osteomalacia is a softening of the bones due to a deficiency of vitamin D or problems with its metabolism, leading to inadequate mineralization of the bone matrix.

    Symptoms include bone pain, muscle weakness, and an increased risk of fractures.
    Vitamin D deficiency, malabsorption issues, or renal problems affecting vitamin D metabolism.
    Treatment methods include Vitamin D and calcium supplements, along with treating underlying causes.

    4. Scoliosis

    Scoliosis is a curvature of the spine, often appearing as an “S” or “C” shape, affecting the body’s posture and alignment.

    Symptoms include visible curvature of the spine, uneven shoulders or hips, back pain, and, in severe cases, difficulty breathing.
    Most cases have no apparent cause (idiopathic), but it can be congenital or due to neuromuscular conditions.
    Treatment methods include monitoring for mild cases, bracing in moderate cases, and surgery for severe curvature.

    5. Renal Osteodystrophy

    This is a bone disease due to chronic kidney disease (CKD), where the kidneys cannot maintain proper mineral balance, leading to bone abnormalities.

    Symptoms include bone pain, fractures, and deformities.
    Causes are an Imbalance in calcium, phosphorus, and vitamin D due to kidney dysfunction.
    Treatment methods include managing CKD, regulating calcium and phosphorus levels, vitamin D supplements, and medications to control bone abnormalities.

    6. Paget Bone Disease

    Paget bone disease is characterized by abnormal bone remodeling, leading to enlarged and weakened bones.

    Symptoms include bone pain, deformities, fractures, and, in some cases, neurological complications.
    Causes are likely due to a combination of genetic and environmental factors.
    Treatment methods include medications like bisphosphonates, calcitonin, and in severe cases, surgery to correct deformities or fractures.

    7. Primary Hyperparathyroidism

    This disorder involves overactivity of the parathyroid glands, leading to excess parathyroid hormone (PTH) production, which regulates calcium levels in the body.

    Symptoms include fatigue, weakness, kidney stones, bone pain, and increased fracture risk due to weakened bones.
    A benign tumor often causes it in one of the parathyroid glands.
    Treatment methods include surgical removal of the abnormal gland (parathyroidectomy), which is the most common treatment.

    I wrote an article titled Here’s How Thyroid Hormones Can Affect Our Health and Well-Being which can be found through a Google search.

    Technological Support for Bone Health and Bone Diseases

    As a technologist, I also investigated relevant technologies and want to summarize them briefly for awareness purposes.

    Technological advancements continue to revolutionize the landscape of bone health, from early detection through advanced imaging techniques to precise and minimally invasive surgeries and innovative approaches in regenerative medicine.

    These developments improve diagnostic accuracy and treatment outcomes, improving patient care and quality of life.

    Technological advancements are pivotal in diagnosing, treating, and managing bone-related disorders. Here’s a more detailed exploration of technological support in bone health:

    1. Diagnostic Technologies

    DEXA (Dual-Energy X-ray Absorptiometry) scans offer precise bone mineral density assessments, pivotal in gauging bone strength and fracture risks.

    These scans are highly accurate and non-invasive, facilitating early identification of osteoporosis and osteopenia. This early detection can empower timely interventions, crucial in preventing potential fractures, thereby significantly improving patient outcomes.

    CT and MRI scans provide detailed imaging of bones, joints, and soft tissues, offering crucial insights into diagnosing various bone diseases, fractures, and spinal conditions.

    These imaging modalities offer comprehensive views that assist healthcare professionals in devising more effective treatment plans and surgical strategies, ensuring optimal patient care.

    2. Surgical Innovations

    Minimally invasive techniques, exemplified by minimally invasive spine surgery (MISS), can significantly decrease tissue damage and recovery periods associated with spinal surgeries.

    These innovative approaches offer patients reduced post-operative discomfort, shorter hospital stays, and faster recoveries, facilitating an earlier return to regular activities and improved quality of life.

    Robotic-assisted surgeries are instrumental in performing orthopedic procedures, notably complex spinal surgeries for scoliosis correction.

    These advanced technologies enhance surgical precision and accuracy, enabling minimally invasive approaches that minimize surgical trauma. As a result, patients experience improved outcomes due to reduced postoperative complications and faster recovery times.

    3 — Biocompatible Implant Technology

    Biocompatible implants, leveraging materials like titanium, can enhance compatibility and diminish the likelihood of rejection or complications post-surgery.

    These advancements ensure increased durability of implants and significantly lower the risk of adverse reactions.

    Consequently, they contribute to more successful surgical outcomes by offering long-lasting solutions with reduced chances of complications.

    5. Digital Health and Monitoring

    In digital health and monitoring, wearable devices and mobile applications play a pivotal role by allowing people to actively monitor their physical activity, nutrition, and various parameters related to bone health.

    These tools empower proactive health management, providing real-time data tracking and personalized insights.

    Consequently, they facilitate improved adherence to exercise routines and lifestyle modifications, empowering individuals to make informed decisions about their health for better overall well-being.

    For my information about this, you may check out my article titled "Digital Therapeutics and Virtual Reality Therapies Can Revolutionize the Healthcare Industry."

    6. Regenerative Medicine

    This futuristic medical avenue holds potential for transformative therapies, offering hope for enhanced healing outcomes and improved quality of life for patients with bone-related conditions.

    In the pioneering field of regenerative medicine, ongoing research explores the potential of stem cell therapy and tissue engineering to revolutionize the treatment landscape.

    This innovative approach utilizes stem cells and engineered tissues to regenerate damaged bone tissues, facilitating accelerated healing of fractures and bone defects.

    The envisioned benefits hold the promise of groundbreaking treatments that promote natural healing mechanisms, ultimately restoring optimal bone function.

    5 Steps to Improve Bone Health

    Step 1 — Address nutritional deficiencies and get sunlight

    Obtaining essential minerals and vitamins from whole foods, whether from animal or plant sources, is vital for overall health, particularly for bone growth, recovery, and maintenance. However, missing out on crucial food groups containing these nutrients may necessitate supplementation under the guidance of qualified healthcare professionals. Calcium, magnesium, zinc, boron, copper, and manganese are the most crucial minerals for bone health, while silicon and vitamins such as Vitamin D and Vitamin K/K2 are equally crucial for bone strength and vitality. Addressing nutritional deficiencies supports bone health and contributes to hormonal balance, metabolic health, and improved insulin sensitivity. Careful sun exposure is a source of Vitamin D, and it has other health benefits too, for those whose skin type allows it.

    Step 2 — Get adequate protein, collagen, and healthy fats.

    Ensuring adequate protein intake, collagen, and healthy fats supports bone health. Clinical trials highlight the inverse association between higher biomarker-calibrated protein intake and forearm fractures with better maintenance of bone mineral density, especially in postmenopausal women. Collagen, essential for connective tissues, including bones and skin, is vital for bone strength, and decreased collagen production weakens bones. Sources like bone broth or collagen-producing ingredients from plants aid in collagen synthesis. Over-the-counter collagen supplements also prove beneficial. Moreover, certain fats, like omega-3, show the potential to positively impact bone health by modulating osteoclast and osteoblast activity. Literature supports the health benefits of omega-3 fatty acids, showcasing their influence on bone health.

    Step 3 — Perform resistance training and moderate cardio.

    Prioritizing regular exercise, especially resistance training and weight lifting, is a pivotal lifestyle choice for bolstering bone health and preventing osteoporosis. Research indicates that these exercises are particularly beneficial, potentially increasing bone mineral density and size while safeguarding against bone loss. They foster muscle building and maintenance and significantly enhance bone density, thus countering decline. Moreover, skeletal muscle health appears intertwined with bone health, suggesting a correlation between preventing sarcopenia and reducing osteoporosis risk, especially among the aging population. Alongside resistance training, moderate cardio exercises complement bone health. However, caution is necessary during high-intensity exercises to prevent potential accidents that may exacerbate osteoporosis. Consistent physical activity aids bone health by promoting hormonal balance, increasing insulin sensitivity, and lowering chronic inflammation, fostering overall well-being.

    Step 4 — Reduce stress with restorative sleep, rest, recovery, leisure, and mindfulness.

    Addressing stress through these methods proves pivotal in fostering optimal bone health, as chronic psychological stress significantly impacts bone mass and quality. Studies reveal stress’s influence on the HPA axis, sympathetic nervous system, and various endocrine and immune factors, leading to decreased bone density. Prioritizing restorative sleep emerges as a cornerstone in stress reduction and improving overall bone health. Supplementing sleep with mindfulness practices like meditation, relaxation techniques, visualization, self-affirmation, music therapy, or hobbies tailored to individual preferences further aids stress management, contributing to bone health and overall well-being.

    Step 5 — Quit Smoking and Drugs and Limit Alcohol Use

    Incorporating nutritional and movement strategies aids bone health, yet evidence underscores the detrimental impact of cigarette smoking and excessive alcohol consumption on osteoporosis. NHS highlights smoking’s association with heightened osteoporosis risk while recommending alcohol consumption not exceeding 14 units weekly to prevent bone weakening. Emphasizing permanent smoking cessation and moderating alcohol intake becomes imperative for osteoporosis prevention and overall health enhancement. Additionally, careful consideration of drugs and certain medications is vital, as highlighted by NIH, citing specific medications, including certain cancer drugs and glucocorticoid steroids, which may heighten osteoporosis risk.

    Conclusions

    Maintaining optimal bone health is vital to overall fitness and well-being, impacting mobility, independence, and quality of life. The prevalence of bone diseases emphasizes the significance of proactive measures to prevent them.

    Prioritizing a balanced diet rich in essential minerals coupled with regular exercise, weight-bearing activities, and resistance training plays a pivotal role in fortifying bone health.

    Additionally, avoiding harmful habits like smoking and excessive alcohol consumption and managing stress while seeking guidance on appropriate medications and therapies from healthcare professionals (orthopedists or orthopedic surgeons) prove instrumental.

    Timely diagnosis, cultivating awareness, adopting preventive measures, and integrating healthy lifestyle choices are imperative steps toward safeguarding bone health and minimizing the risks posed by bone-related disorders.

    Prominent Resources for Further Research

    Instead of referencing many papers, I direct you to authoritative resources (publicly available informative books) developed by the National Library of Medicine, accessible through shortened links under the NBK domain. This approach offers comprehensive and credible information without overwhelming readers with abundant citations, ensuring access to reliable materials curated by reputable sources for further exploration.

    Biomarker-calibrated protein intake and bone health in the Women’s Health Initiative clinical trials and observational study [The American Journal of Clinical Nutrition]
    What does the research say about collagen supplements? [Harvard Medical School]
    An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans [BMC]
    Assessment of Hip Fracture Risk Using Cross-Section Strain Energy Determined by QCT-Based Finite Element Modeling [BioMed]
    Selective Estrogen Receptor Modulators [Asian Spine Journal]
    Osteoporosis [NBK] — Osteopenia [NBK]
    Denosumab [NBK] — Teriparatide [NBK] — Calcitonin [NBK]
    Osteomalacia [NBK] — Adolescent Idiopathic Scoliosis [NBK]
    Renal Osteodystrophy [NBK] — Paget Bone Disease [NBK]
    Primary Hyperparathyroidism [NBK]

    Thank you for reading my perspectives. I wish you a healthy and happy life.

    To inform my new readers, I wrote numerous articles that might inform and inspire you. My topics include brain and cognitive function, significant health conditions, longevity, nutrition/food, valuable nutrients, ketogenic lifestyle, self-healing, weight management, writing/reading, science, technology, business, and humor.

    I compile my health and wellness stories on my blog, EUPHORIA. My posts do not include professional or health advice. I only document my reviews, observations, experiences, and perspectives to provide information and create awareness.


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