The NFL's Week 3 schedule kicks off Thursday with an AFC East matchup between the New England Patriots and New York Jets at MetLife Stadium and will end with a Monday Night Football doubleheader featuring the Jacksonville Jaguars at the Buffalo Bills ( 7:30 p.m. ET on ESPN ) and the Washington Commanders at the Cincinnati Bengals ( 8:15 p.m. ET on ABC and ESPN+ ).
This will be a week of Davids facing Goliaths as far as betting is concerned: Seven of the 16 matchups opened with the favorite giving up at least 6.5 points to the underdog. Fireworks are expected for the Detroit Lions at Arizona Cardinals , who opened with the highest total of the week (51.5), while the Pittsburgh Steelers and Los Angeles Chargers opened with the lowest total of the week at 36.5.
Here's a look at all the Week 3 games. Football Power Index (FPI) by ESPN Sports Analytics. Odds current as of publication time. For most current odds go to ESPN BET
New England Patriots vs. New York Jets -6.5
Thursday 8:15 PM ET, Prime Video
Money Line: Patriots (+230) ; Jets (-280)
Total: 37.5; Opened: 40.5
FPI favorite: Jets by 6.6, 66.7% to win outright
New York Giants vs. Cleveland Browns -6.5
Sunday 1:00 PM ET, FOX
Money Line: Giants (+240) ; Browns (-290)
Total: 38.5; Opened: 38.5
FPI favorite: Browns by 5.7, 64.1% to win outright
Denver Broncos vs. Tampa Bay Buccaneers -6.5
Sunday 1:00 PM ET, FOX
Money Line: Broncos (+260) ; Buccaneers (-320)
Total: 39.5; Opened: 39.5
FPI favorite: Buccaneers by 7.9, 69.1% to win outright
Chicago Bears vs. Indianapolis Colts -2
Sunday 1:00 PM ET, CBS
Money Line: Bears (+110) ; Colts (-130)
Total: 42.5; Opened: 44.5
FPI favorite: Colts by 1.1, 52.9% to win outright
Green Bay Packers vs. Tennessee Titans -3
Sunday 1:00 PM ET, FOX
Money Line: Packers (+135) ; Titans (-155)
Total: 36.5; Opened: 37.5
FPI favorite: Packers by 0.1, 51.2% to win outright
Philadelphia Eagles vs. New Orleans Saints -2
Sunday 1:00 PM ET, FOX
Money Line: Eagles (+105) ; Saints (-125)
Total: 49.5; Opened: 48.5
FPI favorite: Saints by 0.7, 51.1% to win outright
Los Angeles Chargers vs. Pittsburgh Steelers -2
Sunday 1:00 PM ET, CBS
Money Line: Chargers (+105) ; Steelers (-125)
Total: 35.5; Opened: 36.5
FPI favorite: Steelers by 0.5, 51.3% to win outright
Houston Texans -2.5 vs. Minnesota Vikings
Sunday 1:00 PM ET, CBS
Money Line: Texans (-135) ; Vikings (+115)
Total: 45.5; Opened: 46.5
FPI favorite: Texans by 1.7, 54.4% to win outright
Carolina Panthers vs. Las Vegas Raiders -5.5
Sunday 4:05 PM ET, CBS
Money Line: Panthers (+200) ; Raiders (-240)
Total: 40.5; Opened: 38.5
FPI favorite: Raiders by 4.9, 62.5% to win outright
Miami Dolphins vs. Seattle Seahawks -5.5
Sunday 4:05 PM ET, CBS
Money Line: Dolphins (+200) ; Seahawks (-240)
Total: 41.5; Opened: 42.5
FPI favorite: Seahawks by 5.3, 63.2% to win outright
San Francisco 49ers -7 vs. Los Angeles Rams
Sunday 4:25 PM ET, FOX
Money Line: 49ers (-350) ; Rams (+280)
Total: 44.5; Opened: 45.5
FPI favorite: 49ers by 5.3, 64% to win outright
Detroit Lions -3 vs. Arizona Cardinals
Sunday 4:25 PM ET, FOX
Money Line: Lions (-150) ; Cardinals (+130)
Total: 52.5; Opened: 51.5
FPI favorite: Lions by 0.2, 50.1% to win outright
Baltimore Ravens -1 vs. Dallas Cowboys
Sunday 4:25 PM ET, FOX
Money Line: Ravens (-120) ; Cowboys (+100)
Total: 49.5; Opened: 48.5
FPI favorite: Ravens by 1.3, 53.8% to win outright
Kansas City Chiefs -3.5 vs. Atlanta Falcons
Sunday 8:20 PM ET, NBC, Peacock
Money Line: Chiefs (-175) ; Falcons (+150)
Total: 46.5; Opened: 46.5
FPI favorite: Chiefs by 3, 58.3% to win outright
Jacksonville Jaguars vs. Buffalo Bills -5.5
Monday 7:30 PM ET, ESPN
Money Line: Jaguars (+210) ; Bills (-250)
Total: 45.5; Opened: 46.5
FPI favorite: Bills by 6.6, 66.1% to win outright
Washington Commanders vs. Cincinnati Bengals -8
Monday 8:15 PM ET, ABC, ESPN+
Money Line: Commanders (+300) ; Bengals (-380)
Total: 48.5; Opened: 47.5
FPI favorite: Bengals by 5.4, 64% to win outright
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