Columbus, OH

In this video segment, Reau, Trivedi, and Hirschfield discuss the availability of new second-line treatment options and their role in PBC management compared to traditional therapies like UDCA and OCA. In recognition of the US Food and Drug Administration accelerated approval of Gilead's seladelpar (Livdelzi) and other recent evolutions in...

Recent Advances in Second-Line Therapies in PBC

Gilead’s Livdelzi, a selective peroxisome proliferator-activated receptor delta agonist, has received accelerated FDA approval for the treatment of primary biliary cholangitis, according to a company release. Perspective from Gideon Hirschfield, PhD. Livdelzi (seladelpar) was approved for use in combination with ursodeoxycholic acid (UDCA) in adult patients who did not...

FDA approves Gilead’s Livdelzi for treatment of primary biliary cholangitis

Doctors can diagnose fatty liver disease, now called metabolic dysfunction-associated steatotic liver disease (MASLD), using blood tests that measure serum liver enzyme levels. Elevated enzyme levels may indicate inflammation and disease in the liver. Instead of nonalcoholic fatty liver disease (NAFLD), experts now call it metabolic dysfunction-associated steatotic liver disease...

What Blood Tests Can Diagnose Fatty Liver Disease?

A second dendritic cell vaccine has received fast track designation from the Food and Drug Administration. The Food and Drug Administration (FDA) has granted a fast track designation to a dendritic cell vaccine for the treatment of patients with pancreatic ductal adenocarcinoma. Immuno-oncology company Diakonos Oncology Corporation announced the designation...

FDA Fast Tracks Pancreatic Cancer Vaccine

Interesting Engineering

Patients experienced a significant reduction in pain, improved their quality of life, and even showed signs of cartilage regrowth.

Stem cell shot reverses osteoarthritis, repairs knee cartilage, cuts pain by 58%

Reuters

(Reuters) -The U.S. Food and Drug Administration on Wednesday approved Gilead Sciences' liver disease treatment, Livdelzi, which it gained through a $4.3 billion buyout of CymaBay Therapeutics earlier this year.

Gilead gets US FDA approval for inflammatory liver disease drug

Las Vegas, NV

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Bellingham Metro News

LAS VEGAS, NEVADA - A magnitude 4.4 earthquake struck areas near Las Vegas on Tuesday night, according to the United States Geological Service (USGS). The quake, which occurred at 8:06 p.m., was centered approximately 45 minutes from Las Vegas, near Indian Springs.

Magnitude 4.4 Earthquake Shakes Areas Near Las Vegas

Diabetic nephropathy is a form of long-term, chronic kidney disease resulting from having had diabetes for several years. Diabetes causes higher-than-normal blood glucose levels, which damage some of the kidney’s blood vessels over time. Damaged blood vessels in the kidneys and other factors, like inflammation, lead to kidney damage.

Exploring the Impact of Diabetic Nephropathy on Kidney Health

The study was not adequately powered to assess a significant association with cancer mortalities. A new study has found a negative correlation between serum vitamin D and mortality in patients with gout and a U-shaped relationship in patients with hyperuricemia (HUA).1. “Though there are several major advances in gout treatment,...

Vitamin D Associated With Lower Risk of Mortality in Patients With Gout, Hyperuricemia

Everyday Health

Learn about eosinophilic esophagitis (EoE) and its symptoms, including chronic cough, treatment options, and diagnosis methods.

Can Eosinophilic Esophagitis Be the Reason Behind Your Chronic Cough?

Avidity Biosciences‘ delpacibart zotadirsen, or del-zota for short — formerly called AOC 1044 — was found to safely increase levels of dystrophin production to 25% of normal in people with Duchenne muscular dystrophy (DMD), according to new data from the EXPLORE44 trial. In the Phase 1/2 clinical...

Del-zota increases dystrophin in DMD patients, new trial data show

Livdelz is an oral therapy to treat patients with primary biliary cholangitis, a progressive autoimmune disease. It is expected to be available in pharmacies next week. The FDA has granted accelerated approval for Livdelzi (seladelpar) to treat patients with primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA). PBC is a progressive autoimmune disease that results from the destruction of the bile ducts in the liver. This leads to inflammation, scarring and cirrhosis. The disease affects mostly women.

FDA Grants Accelerated Approval for Rare Liver Disease Drug

Colorado State

David Heitz

A bill quietly introduced this spring in the Colorado legislature to decriminalize the possession of drug paraphernalia obtained by harm reductionists has become law. As low-key as the legislation was introduced, the bill was signed into law without fanfare June 6. It garnered little to no media attention.

Colorado legalizes needles, pipes for meth and crack if obtained by harm reduction group

Medications for Crohn's disease—a chronic, progressive, and relapsing inflammatory bowel disease (IBD)—include a variety of conventional and newer prescription therapies. These include drugs such as aminosalicylates, steroids, and antibiotics. Other novel treatments approved in recent years include biologics and immunosuppressants. All of these treatment options aim to decrease immune system activity to reduce inflammation.

Medications for Crohn’s Disease

Findings suggest increased intensity of IgM deposits in patients with positive IgM deposition may contribute to adverse clinicopathologic presentation and clinical outcomes. Findings from a recent study are providing clinicians with an overview of the value of glomerular IgM deposit intensity in patients with IgA nephropathy (IgAN).1. Although results showed...

Glomerular IgM Deposit Intensity Shows Clinical Significance in IgA Nephropathy

People may be at more risk of both AIDS and hepatitis B due to similar risk factors. Having HIV and hepatitis B may lead to serious complications. However, both are treatable and preventable. Stage 3 HIV is also known as AIDS. Stage 3 HIV is the most advanced stage of...

Stage 3 HIV (AIDS) and hepatitis B: What is the connection?

Crexont kept symptoms at bay for an extra 30 minutes a day when compared with other Parkinson’s drugs. Amneal Pharmaceuticals Inc. announced yesterday the FDA approval for Parkinson’s drug Crexont (carbidopa and levodopa) via a news release on their website. This novel medication, formerly known as IPX203, combines two common drugs into one capsule.

FDA Approval Granted for Novel Parkinson’s Treatment

A new drug application has been submitted to the FDA for UGN-102 inlow-grade, intermediate-risk non–muscle-invasive bladder cancer. A new drug application (NDA) has been submitted to the FDA seeking the approval of mitomycin for intravesical solution (UGN-102) for the treatment of patients with low-grade, intermediate-risk non–muscle-invasive bladder cancer (NMIBC).1.

FDA Approval Sought for UGN-102 in Low-Grade, Intermediate-Risk NMIBC

Acute kidney injury (AKI) is one of the most frequent complications of cardiac surgery and the cause is complex. Renal hypoperfusion from decreased glomerular filtration rate after cardiopulmonary bypass is a major contributor. 1 This in combination with exogenous toxins, endogenous metabolites, oxidative stress, bleeding and reperfusion injury can all...

The PROTECTION Trial – A Randomized Trial of Intravenous Amino Acids for Kidney Protection

Gene therapy is an emerging treatment for both wet and dry macular degeneration. It requires fewer eye injections than standard treatments. Macular degeneration, also called age-related macular degeneration (AMD), affects your ability to see things straight ahead of you. This makes it difficult to perform daily activities like reading and driving.

Can Gene Therapy Cure Macular Degeneration?

NewsBreak

Considerations for Treatment Sequencing in Primary Biliary Cholangitis

In this video segment, Reau, Trivedi, and Hirschfield discuss how treatment sequencing in PBC has evolved over time with the emergence of new second-line therapies and...

Considerations for Treatment Sequencing in Primary Biliary Cholangitis

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