Minnesota State

Cleveland, OH

Case Western Reserve University in Cleveland has announced a three-year, $1.5 million grant from the Foundation Fighting Blindness (FFB) to advance testing of a new treatment for retinitis pigmentosa, an inherited retinal disease. A previous three-year FFB-funded drug discovery program—led by Case Western associate professor of ophthalmology and visual sciences...

CWRU receives $1.5 million to advance retinitis pigmentosa research

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NewSantaAna

The FBI has seen a rise in scams targeting timeshare owners. In this kind of scam, criminals con these part-time property owners into shelling out hefty sums of cash, all under false pretenses related to their timeshare properties.

FBI warns that Mexican cartels are targeting Americans with timeshare scams

A recent study published in the Journal of Ethnopharmacology has highlighted the potential anti-cancer properties of cannabis oil extract (COE) in the treatment of acute myeloid leukemia (AML). The study, published online this week by the US National Library of Medicine, explores the effectiveness of COE in both cellular and...

Study: Marijuana Oil Shows Potent Anti-Cancer Effects Against Acute Myeloid Leukemia

Chicago, IL

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Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

New York City, NY

Cheryl E Preston

Yesterday was the third time this year that an ad stating Chelsea Clinton lives in a beautiful Virginia home popped up on my laptop. My computer did not warn me this was a dangerous site, so this time, I clicked on the link.

Chelsea Clinton is rumored to be living in Virginia but probably still in NYC

Bacon County, GA

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Daily Coffee Press

On Monday, a search at a Bacon County home by investigators resulted in the discovery of a large quantity of illegal drugs, including methamphetamine and cocaine. However, the suspects are currently not in custody.

Drug Bust Uncovers Methamphetamine and Cocaine in Bacon County Residence

Healthline

Spinal muscular atrophy (SMA) type 0 is a rare genetic disorder that is present before birth and requires immediate care. Learn more.

What is Spinal Muscular Atrophy Type 0?

Wyoming State

WyoFile

Caitlin Tan wanted to breed her childhood horse, JP, because she’s been “amazing” — the type of animal any equestrian would be lucky to have once in a lifetime. Having access to coveted bloodlines increased the allure. Via the Miller Ranch, she could pair her 18-year-old mare with a stud descendent of Playboy’s Buck Fever.

Cream of the crop: a cremello foal is born in Wyoming

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

Emerging data from Phase I first-in-human, dose-escalation study showed promising survival and progression-free survival rates. The FDA has granted Fast Track Designation to Obsidian Therapeutics’ OBX-115, a novel engineered tumor-derived autologous T cell immunotherapy (tumor-infiltrating lymphocyte [TIL] cell therapy) armored with pharmacologically regulatable membrane-bound IL15 (mbIL15), for the treatment of patients with metastatic or locally advanced melanoma that is refractory to or has relapsed after PD-1/PD-L1–based immune checkpoint inhibitors (ICI).1.

FDA Grants Fast Track Designation for OBX-115 for the Treatment of Advanced Melanoma

Aurora, CO

David Heitz

Aurora’s pallet shelters for people experiencing homelessness, which only allow a maximum 30-day stay, have been cycling the same individuals in and out, city staff told council members Thursday. Many return to street encampments when their time in the pallet shelter runs out, Jessica Prosser, homeless services director for the city, said. Then, the city sweeps the encampment again, and they get to come back to the shelter for another 30 days, Prosser explained. This process can repeat multiple times.

Aurora pallet shelters a revolving door for homeless

Kentucky State

Northern Kentucky Tribune

Kentucky’s Community Actions Partnerships have announced the starts date for the Low-Income Home Energy Assistance Program (LIHEAP) Summer Subsidy, aimed at helping Kentucky households offset summer cooling costs.

LIHEAP Summer Subsidy program to help with summer cooling costs to begin enrollment July 16

HealthDay News — Prenatal vaccination with a nonadjuvanted bivalent respiratory syncytial virus (RSV) prefusion F (RSVpreF) protein subunit vaccine is not associated with an increased risk for preterm birth (PTB), according to a study published online in JAMA Network Open. In a retrospective observational cohort study, Moeun Son, MD,...

Prenatal Vaccination With RSV Prefusion F Does Not Increase Risk for Preterm Birth

California State

Alameda Post

California regulators just stopped AT&T from pulling the plug. California’s Public Utilities Commission on June 20 rejected AT&T’s application to stop providing landlines and other services in areas where there is no other option.

Still Need Your Landline?

Nagoya University researchers found that deficiencies in gut bacteria genes for vitamins B2 and B7 are linked to Parkinson’s disease, suggesting that B vitamin supplementation could be a potential treatment. A study conducted by the Nagoya University Graduate School of Medicine in Japan has discovered a connection between gut...

New Study Links Gut Vitamin B Deficiency to Parkinson’s Disease

Missouri State

Fulton, MO

CJ Coombs

Bringing them home: for 40 years, the National Center for Missing and Exploited Children (NCMEC) has been helping to locate missing children. Since July 1, 2024, according to the NCMEC, 15 children have been reported missing in the U.S. Not included in that number are those who have been missing in Missouri since June 2024.

Seven teenagers have been missing in Missouri since June 2024

Gov. Andy Beshear announced on Thursday the successful launch of a statewide drug operation by the Kentucky State Police (KSP) known as “Operation Summer Heat,” following a three-month investigation into suspected drug trafficking rings.

KSP’s Operation Summer Heat makes 206 drug trafficking arrests, saving lives in safer state

Patients with pre-treated relapsed or refractory follicular lymphoma have shown benefits with mosunetuzumab. High-risk participants with heavily pre-treated relapsed or refractory follicular lymphoma (FL) benefited from mosunetuzumab in terms of clinical remission and survival outcomes. The benefit of mosunetuzumab was consistent in participants who had disease progression within 2 years (POD24), a factor associated with poor outcomes.

Mosunetuzumab Benefits Outcomes Across Follicular Lymphoma Subgroups

Massachusetts State

Dianna Carney

Sandy Paws Rescue Inc., a foster-based rescue in Massachusetts, recently introduced a six-year-old French bulldog named Joannie who is looking for her forever home. The local animal rescue explains: “Joannie was found as a stray extremely emaciated and less than half her current weight now. She was missing fur on her body, face and ears. She has been nursed back to health and is doing wonderfully. While her age and exact history is unknown, it is clear she has mothered more than enough litters in her short lifetime.”

Meet Joannie: The "Extreme Snuggler" French Bulldog Looking For Love

Pennsylvania State

Bucks County Beacon

With an assassination attempt on Donald Trump at a rally in Pennsylvania on July 13, 2024, the U.S. experienced another violent episode in its increasingly polarized politics. Former President Trump, who’s about to formally become the GOP nominee for president in the 2024 election, survived the attempted assassination when, initial reports said, a bullet grazed his ear . But one rally attendee was killed , more spectators were injured and the suspected gunman is also dead. The Conversation’s politics editor, Naomi Schalit, spoke with University of Massachusetts, Lowell, scholar Arie Perliger after the event. Perliger offered insight from his study of political violence and assassinations. Given the stark political polarization in the U.S., Perliger said, “it’s not a surprise that eventually people engage in violence.”

‘One Inch from a Potential Civil War’? Trump Shooting a Close Call for American Democracy

NewsBreak

Minnesota Ovarian Cancer Alliance issues RFP for early detection research

The Minnesota Ovarian Cancer Alliance (MOCA) has requested proposals for its National Early Detection of Ovarian Cancer Research Awards. Through the program, MOCA will award grants...

Minnesota Ovarian Cancer Alliance issues RFP for early detection research

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