All 3 participants who have follow-up of at least 1 year have met the endpoint so far. Data continue to support VX-880 (Vertex Pharmaceuticals)’s potential to eliminate or reduce the need for insulin use in patients with type 1 diabetes (T1D).1. Updated data from the phase 1/2 FORWARD trial...

Vertex’s Diabetes Cell Therapy on Track to Meet Endpoint of Eliminating Severe Hypoglycemic Events

Metformin, a medication commonly used to treat type 2 diabetes, helps the body regulate sugar in the bloodstream. Part of the class of drugs known as biguanides, metformin reduces the amount of sugar you absorb from food and the amount produced by the liver. Metformin also impacts the way the body will respond to insulin, the natural substance that regulates blood sugar levels.

Diabetes Drug Metformin Investigated for Cancer Prevention Use

Everyday Health

Alcohol and diabetes: How to manage the dangers of alcohol, understanding the risks of hypoglycemia, and predicting the impact of drinking on blood sugar levels.

Diabetes and Alcohol: What You Need to Know

Diabetes, or diabetes mellitus, is to a group of chronic conditions that affect your glucose (blood sugar) levels due to problems with the way your body produces or uses the hormone insulin. In rare cases, diabetes can lead to the complication bullosis diabeticorum, also known as diabetic blisters or diabetes bullae.

Diabetic Blisters: A Symptom of Mismanaged Diabetes?

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

Using insulin to manage type 1 or type 2 diabetes is complicated stuff. Almost everything you eat requires at least one dose, and exercise and other factors change the insulin math considerably. Insulin pumps make it pretty easy to deal with these complex daily changes — but you don’t need an insulin pump to thrive and reach your A1C goals.

How I Maintain a 6 Percent A1C Without an Insulin Pump

Ozempic (semaglutide) is a brand-name drug, while metformin is a generic drug. They’re both prescribed to help manage blood sugar levels in people with type 2 diabetes. This article explains the main similarities and differences between Ozempic and metformin. If you’re considering taking one of these drugs, discussing this information with your doctor can help you decide whether one of these treatments may be right for you.

Ozempic vs. metformin

rolling out

Managing blood sugar levels is crucial for overall health, especially for those diagnosed with diabetes or prediabetes. High blood sugar can lead to various complications; however, with the right strategies, you can keep it under control. This article will guide you through effective ways to manage your blood sugar levels, offering practical tips and insights to help you stay healthy.

How to get your blood sugar level under control

Medical News Today

Recent research suggests that moderate-to-vigorous physical activity in the evenings could help maintain blood sugar levels in a healthy range.

When is it best to exercise in order to maintain healthy blood sugar levels?

When you’re first wearing a CGM, be sure to share your data with your healthcare team – doing so can help you identify patterns and better manage your diabetes. CGM can help prevent low blood sugar, especially during physical activity. Seeing real-time glucose data can also help you...

5 Ways CGM Can Optimize Diabetes Management

UPI News

About 1 in 4 people (24%) with tough-to-treat Type 2 diabetes have elevated cortisol levels, researchers found.

Cortisol appears to play role in tough-to-treat diabetes

If you are living with diabetes, you may already know you are at higher risk for cardiovascular disease, including heart attack, heart failure, and stroke. According to the Centers for Disease Control and Prevention (CDC), people who have diabetes are twice as likely to have cardiovascular disease. What you may not know is that it is important for someone with diabetes to maintain low LDL cholesterol because your blood LDL cholesterol level is a contributing factor to cardiovascular disease.

Statins: A Powerful Ally for People Living with Diabetes

The results were presented at a symposium during the American Diabetes Association's 84th Scientific Sessions in Orlando, Florida, and mark the first large-scale trial specifically designed to investigate the effect of fenofibrate on eye outcomes in people with early diabetic retinopathy. Results from the Lowering Events in Non-proliferative retinopathy in...

Study: Common cholesterol-lowering drug found to slow vision loss in patients diagnosed with diabetes

Approval of Skyrizi marks the first IL-23 specific inhibitor approved for both ulcerative colitis and Crohn disease of similar severity, according to AbbVie. The FDA has approved AbbVie’s Skyrizi (risankizumab-rzaa) for the treatment for adults with moderately to severely active ulcerative colitis (UC). According to the company, this approval makes Skyrizi the first IL-23 specific inhibitor to be approved for both UC and Crohn disease classified as moderate-to-severe. The approval was based on results from the INSPIRE Induction study and the COMMAND Maintenance study. In addition to the approved indications for UC and Crohn disease, Skyrizi also has been approved for active psoriatic arthritis and plaque psoriasis.1.

FDA Approves AbbVie’s Skyrizi for the Treatment of Adults with Moderate to Severely Active Ulcerative Colitis

The following is a summary of “Are there lost opportunities in chronic kidney disease? A region-wide cohort study,” published in the April 2024 issue of Nephrology by Sundström et al. Chronic kidney disease (CKD) is a long-term condition where kidneys do not work effectively, leading to waste...

Underdiagnosis and Undertreatment of CKD Highlight Need for Early Detection and Treatment to Improve Outcomes

After following patients for more than 10 years, arrhythmias were considered the most important cardiac predictor of survival, with progressive neurologic disability and diabetes mellitus identified as further major contributors. Using data from a prospective registry of patients with Friedreich ataxia (FA), recently published findings indicated that progressive neurological disability,...

Arrhythmias, Neurologic Disability, and Diabetes Mellitus Lead to Greater Mortality in Friedreich Ataxia

A study compared 5:2 intermittent fasting, done with meal replacements, to diabetes medications for the treatment of type 2 diabetes. People who did intermittent fasting lost more weight and saw greater improvement in blood glucose control. The 5:2 intermittent fasting diet involves eating 25% of your usual calories on two...

Intermittent Fasting Can Help People With Type 2 Diabetes Control Blood Sugar, Weight Loss

Diabetes drugs known as GLP-1 agonists are linked to a lower risk of dementia compared to other diabetes drugs known as sulfonylureas and DPP-4 inhibitors. As type 2 diabetes increases a person’s risk of dementia, the findings may help inform treatment options for patients with diabetes. The corresponding study was published in eClinicalMedicine.

Diabetes Drug Show Promise for Reducing Dementia Risk

HealthDay News — Empiric vitamin D supplementation is suggested for those aged 1 to 18 years, those older than 75 years, those who are pregnant, and those with high-risk prediabetes, according to an Endocrine Society clinical practice guideline published online in the Journal of Clinical Endocrinology & Metabolism. Marie...

Vitamin D Suggested for Children, Seniors, Those With High-Risk Prediabetes

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Chicago Happenings

What is more summery than an icy, sweet frozen drink? If the heat wave is getting to you, try whipping up this simple frozen strawberry lemonade. All you need is your choice of lemonade and some frozen strawberries. You can use store-bought lemonade, make your own from scratch, or a powdered version. As for strawberries, frozen ones are the easiest choice. If you'd rather use fresh, add at least two cups of ice until you reach a nice, frozen consistency.

2-Ingredient Frozen Strawberry Lemonade: Beat the Heat!

NewsBreak

CGM Linked to HbA1c Improvements in Patients with Type 2 Diabetes, Regardless of Insulin Use

Study results highlight the impact of continuous glucose monitoring on glucose control and HbA1c improvements in patients with type 2 diabetes, regardless of treatment regimen. Findings...

CGM Linked to HbA1c Improvements in Patients with Type 2 Diabetes, Regardless of Insulin Use

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