Ozempic (semaglutide) is a brand-name drug, while metformin is a generic drug. They’re both prescribed to help manage blood sugar levels in people with type 2 diabetes. This article explains the main similarities and differences between Ozempic and metformin. If you’re considering taking one of these drugs, discussing this information with your doctor can help you decide whether one of these treatments may be right for you.

Ozempic vs. metformin

Ohtuvayre is the first inhaled product with a novel mechanism of action for chronic obstructive pulmonary disease to be approved in 20 years. The FDA has approved Verona Pharma’s Ohtuvayre (ensifentrine) for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adult patients. Classified as a first-in-class selective dual inhibitor of phosphodiesterase 3 and 4 (PDE3 and PDE4), the treatment combines bronchodilator and non-steroidal anti-inflammatory effects in one molecule. According to the company, this marks the first time in 20 years that an inhaled product with a novel mechanism of action has been approved for COPD maintenance.1.

FDA Approves Verona’s Ohtuvayre for the Maintenance Treatment of Chronic Obstructive Pulmonary Disease

Missouri State

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CJ Coombs

The first time my family walked into a Ponderosa Steakhouse was in the late 1960s. It was new and the experience was great. Like other new restaurants, if the management doesn't stay on top, the quality of service can decline. The location we went to did change through the years, but in the beginning, it was great.

The 1960s: the Ponderosa and Bonanza Steakhouses are still around in some states

Vitamin B12 deficiency is common. It can lead to various health issues, affecting everything from energy levels to brain function. Vitamin B12, or cobalamin, is an essential nutrient in meat, fish, and dairy products. It is crucial for red blood cell production and a healthy nervous system. When B12 levels...

Unusual symptoms of B12 deficiency

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NewSantaAna

The FBI has seen a rise in scams targeting timeshare owners. In this kind of scam, criminals con these part-time property owners into shelling out hefty sums of cash, all under false pretenses related to their timeshare properties.

FBI warns that Mexican cartels are targeting Americans with timeshare scams

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

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Total Apex Sports & Entertainment

We all know people with a ‘sixth sense’ who seem to be just a little more in tune with the world than everyone else. Do you know which zodiac signs they probably are? We can’t be sure, but we’ll share the three signs most likely to have that bonus sense. Having six senses can be a burden and a blessing, and you just may find if you are one of these three signs that some things in your life can be explained by having an extra sense.

3 Zodiac Signs Who Have A Great Sixth Sense

California State

Alameda Post

California regulators just stopped AT&T from pulling the plug. California’s Public Utilities Commission on June 20 rejected AT&T’s application to stop providing landlines and other services in areas where there is no other option.

Still Need Your Landline?

Astrology can provide insights into various personality traits within their zodiac signs. This includes those that might make someone appear mean or harsh. While every sign has its positive and negative aspects, some signs are known for their more unforgiving nature.

3 Zodiac Signs That Are the Meanest

Clark County, WA

Timothy A Gruver

Dentist Ellis B. Jardine of Clark County has been suspended for allegedly practicing outside the scope of his licenses and subpar care, the Washington State Department of Health reported on Friday.

Dentist Suspended for Subpar Care & Unlicensed Practices

A new study emphasizes the importance of controlling hypertension early in diabetes, even before the onset of diabetic retinopathy. Photo: British Heart Foundation. Calcium channel blockers (CCB) are commonly prescribed to treat hypertension, but the literature suggests that these drugs may increase the risk of primary open-angle glaucoma (POAG). Since both of these often comorbid conditions are highly prevalent in Black populations, researchers turned to the NIH All of Us dataset, a cohort known for its demographic, geographic and medical diversity as well as its inclusion of historically underrepresented groups. They found that certain CCBs are associated with a significantly higher risk of developing POAG.

Blood Pressure Medication May Increase POAG Risk

Alcoholic hepatitis, also known as alcohol-induced hepatitis, is liver inflammation caused by drinking large amounts of alcohol over many years. It is a more advanced stage of alcohol-associated fatty liver disease (AFLD), in which the high consumption of alcohol causes a buildup of fat in the liver, leading to liver inflammation (hepatitis).

Alcoholic Hepatitis and Liver Damage: What to Know

Alameda, CA

City experts found spray tests posed little to no risk. City Council voted after midnight on Wednesday, June 5, to end the University of Washington (UW) cloud brightening experiment that researchers were conducting in partnership with the USS Hornet Sea, Air, & Space Museum. The unanimous decision came after the City asked UW to pause the experiment in early May, citing that it was in violation of the City ’s lease with the Museum.

Council Votes Unanimously to End Climate Experiment

ND0612, an investigational agent, had supportive data from the pivotal phase 3 BouNDless trial, a large-scale, phase 3 study of patients with Parkinson disease. According to a recent announcement, the FDA has issued a complete response letter (CRL) to NeuroDerm for its submission of ND0612, a 24-hour/day subcutaneous infusion of liquid levodopa/carbidopa (LD/CD), as a potential treatment for ON time in Parkinson disease (PD). Mitisubishi Tanabe Pharma and its wholly owned subsidiary, NeuroDerm, noted that they are reviewing the CRL and will work closely with the FDA to address its comments to consider the future direction.1.

Parkinson Therapy ND0612 Receives Complete Response Letter

Chicago Happenings

What is more summery than an icy, sweet frozen drink? If the heat wave is getting to you, try whipping up this simple frozen strawberry lemonade. All you need is your choice of lemonade and some frozen strawberries. You can use store-bought lemonade, make your own from scratch, or a powdered version. As for strawberries, frozen ones are the easiest choice. If you'd rather use fresh, add at least two cups of ice until you reach a nice, frozen consistency.

2-Ingredient Frozen Strawberry Lemonade: Beat the Heat!

Study results highlight the impact of continuous glucose monitoring on glucose control and HbA1c improvements in patients with type 2 diabetes, regardless of treatment regimen. Findings from a recent study are calling attention to the significant impact of continuous glucose monitoring (CGM) on glucose control in patients with type 2...

CGM Linked to HbA1c Improvements in Patients with Type 2 Diabetes, Regardless of Insulin Use

In the realm of lymphoma and chronic lymphocytic leukemia (CLL), and of the treatments that address them, a global survey of nearly 7000 patients proves there’s a long way to go to eliminate cancer-related fatigue from their lives. Cancer-related fatigue (CRF) unfortunately remains an unmet need: prevalent, underreported, poorly...

Tired of It: Cancer-Related Fatigue in Lymphoma, CLL

The U.S. Food and Drug Administration (FDA) has rejected for the second time AbbVie’s application of ABBV-951 (foscarbidopa/foslevodopa) for treating motor fluctuations in adults with advanced Parkinson’s disease. In a complete response letter to AbbVie, the FDA said the decision is based on observations from an inspection at...

FDA issues second rejection of ABBV-951 for motor fluctuations

Fareeha Arshad

Researchers at the University of Cincinnati College of Medicine conducted a pilot clinical trial exploring the potential of spinal cord stimulation as a treatment for depression. In the trial, 20 volunteers with depression received a customized low-level electric buzz delivered through a device placed on their spinal cord. Half of the volunteers received the active stimulation, while the other half received a placebo.

Pilot Study Reveals Spinal Cord Stimulation Eases Depression Symptoms

The HD Post

CALIFORNIA – California Assembly members voiced concerns, May 14, over a proposed 47 cent gas increase in 2025 and annual increases, to the California Air Resources Board (CARB).

Assembly members voice concerns over proposed 47 cent per gallon gas increase in 2025

NewsBreak

Melodia buys rights to potential AAV therapy MDI-0151

Melodia Therapeutics has acquired the exclusive rights to develop, manufacture, and commercialize MDI-0151, a candidate therapy for hard-to-treat ANCA-associated vasculitis (AAV) and other disorders marked by...

Melodia buys rights to potential AAV therapy MDI-0151

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