Columbus, OH

Summary: Adjusting melanocortin proteins in the brain enhances the effectiveness of GLP-1 diabetes and weight-loss drugs. By inhibiting MC3R or activating MC4R, mice showed increased sensitivity to these drugs, leading to more significant weight loss and reduced feeding without additional side effects. This discovery could improve treatment outcomes for patients...

Adjusting Proteins Increases Ozempic’s Effectiveness

Summary: Researchers have identified the SH2B1 gene’s crucial role in regulating food intake and energy expenditure. Mutations in SH2B1 are linked to obesity, type 2 diabetes, and metabolic dysfunction-associated liver disease. The gene’s activity in the brain’s paraventricular hypothalamus (PVH) and its interaction with the dorsal raphe nucleus influences...

Obesity Gene Influences Brain Activity

Summary: Researchers have identified how the brain’s default mode network (DMN) collaborates with other regions to produce creative thought. By using advanced brain imaging techniques, they tracked real-time brain activity during creative tasks. This study reveals that the DMN initiates creative ideas, which are then evaluated by other brain...

Creativity’s Neural Origin Revealed

Summary: A new study identifies beta frequency neural activity in the anterior cingulate cortex (ACC) as crucial for recognizing rewards and shaping behavior. This neural signature is altered in patients with depression, suggesting it could serve as a biomarker and potential treatment target for anhedonia. The research highlights how brain...

Beta Brain Waves: A Novel Brain Signature for Depression

Chicago, IL

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Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

Virginia State

Cheryl E Preston

History Facts lists eight names US parents no longer give their newborns, which you may no longer hear in Virginia. The girls' names are Doris, Gertrude, Mildred, and Judith. I know or have known women with all four names, but they are either baby boomers or boomer parents' ages and someone's grandma or great aunt. Consider the ages of females in Virginia you know with these names.

Eight names parents in Virginia may no longer be giving to their newborns

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Total Apex Sports & Entertainment

Conflicts are inevitable in life as we have different opinions. Some zodiac signs are good at arguing while others strive to create harmony and avoid arguments. Yet, conflict resolution is a crucial skill at home and work. It helps people live peacefully and in unity.

5 Zodiac Signs Who Are Most Likely to Win Arguments

Kentucky State

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Northern Kentucky Tribune

Kentucky’s Community Actions Partnerships have announced the starts date for the Low-Income Home Energy Assistance Program (LIHEAP) Summer Subsidy, aimed at helping Kentucky households offset summer cooling costs.

LIHEAP Summer Subsidy program to help with summer cooling costs to begin enrollment July 16

Denver, CO

David Heitz

A dangerous drug that is being mixed into fentanyl is causing those who inject it to develop a rash of sores that resembles a case of flesh-eating bacteria. People experiencing homelessness around Denver can sometimes be seen with these bloody, weeping wounds. I recently mentioned this phenomenon to a fentanyl user who told me about the xylazine connection.

Denver homeless people suffer sores as xylazine enters fentanyl supply

Wyoming State

WyoFile

Caitlin Tan wanted to breed her childhood horse, JP, because she’s been “amazing” — the type of animal any equestrian would be lucky to have once in a lifetime. Having access to coveted bloodlines increased the allure. Via the Miller Ranch, she could pair her 18-year-old mare with a stud descendent of Playboy’s Buck Fever.

Cream of the crop: a cremello foal is born in Wyoming

Massachusetts State

Dianna Carney

Egg Roll is a one-year-old, 34lb American Bully who has recently been introduced by Sandy Paws Rescue Inc., a foster-based rescue located in Massachusetts. This charming, round little dog is looking for his forever home and comes with a delightful personality and some special quirks.

Meet Egg Roll: The Round Little Snuggle Buddy Looking For Love

Washington State

Mill Creek, WA

Timothy A Gruver

The Washington State Department of Labor & Industries reported on Wednesday that it fined four roofing contractors more than a million dollars for letting their workers perform on top of homes without fall protection gear, among other safety violations.

Roofing Companies Fined $1.27M for Endangering Workers

South Carolina State

Explore Beaufort SC

Manatees are back in Lowcountry waters and residents in the coastal areas of South Carolina should be particularly alert while boating and please report sightings of these gentle giants to SCDNR.

Manatees are back in South Carolina coastal waters

Hammy and Cheyanne, two miniature poodles, are in search of their forever home. Weighing 6.3lb and 6.4lb respectively, these sweet pups are a bonded pair with a sad past. Sandy Paws Rescue Inc., a foster-based rescue in Massachusetts, shares their story, explaining that "Hammy & Cheyanne are cruelty case pups that are a bonded pair. They're from a rural area in Texas. These are a pair of sweet little pups that are in need of a fresh start together!"

Meet The Sweet Little Dogs Who Are Looking For Love

Chloe, a 9 to 10-week-old puppy, is the last of her litter and is eagerly looking for a forever home. Sandy Paws Rescue Inc., a dedicated foster-based rescue in Massachusetts, recently shared Chloe's story and her endearing qualities.

Meet Chloe: The 10-Week-Old Puppy Who Is The Last Of Her Litter Looking For Love

Camilo Díaz

(MA) Meet Cooper Cutie, an 8-and-a-half-month-old puppy who is part Shepherd, part Hound, part Treeing Walker Coonhound, and a few other parts thrown in. Whatever the combination, the result was an adorable and unique-looking puppy with ears to melt your heart. Cooper was found with his brother as a stray trying to find enough food to get by. While his brother has since been adopted, Cooper has been waiting in rescue now for over 6 months! Are YOU just who he has been waiting for?

Cooper Cutie Is A Unique Looking Pup Still Searching For Love After Brother Adopted Without Him

Sandy Paws Rescue Inc., a foster-based rescue in Massachusetts, recently introduced an adorable puppy named Koi who they describe as a “sweet and happy little puppy who found himself dumped at a high kill shelter for unknown reasons.” Despite the harsh start to his life, Koi remains an adorable and energetic puppy. Now, thanks to Sandy Paws Rescue Inc. giving him a second chance and rescuing him from the high-kill shelter, Koi is ready for adoption and looking for his forever home.

Meet Koi: The Sweet & Happy Little Puppy Dumped At A High-Kill Shelter

Sandy Paws Rescue Inc., a foster-based rescue in Massachusetts, recently introduced a six-year-old French bulldog named Joannie who is looking for her forever home. The local animal rescue explains: “Joannie was found as a stray extremely emaciated and less than half her current weight now. She was missing fur on her body, face and ears. She has been nursed back to health and is doing wonderfully. While her age and exact history is unknown, it is clear she has mothered more than enough litters in her short lifetime.”

Meet Joannie: The "Extreme Snuggler" French Bulldog Looking For Love

Scituate, MA

The Scituate Animal Shelter of Massachusetts has announced a heartwarming and adorable event that will both raise money for the local animal shelter while also socializing a few of their tiniest furry friends. The local animal shelter explains, "We need help socializing 12 adorable kittens! Your job would be to hang out with them, play with them and pet them!"

Local Animal Shelter Announces Adorable "Play With Kittens" Event

The Animal Rescue of New England recently introduced Cagney and Lacey, two adorable German Shepherd puppies, who are now ready to find their forever home. These lively girls were saved from a shelter on the day they were due to be euthanized due to overcrowding. At approximately five months old, both puppies are brimming with energy and love.

Puppies Saved On The Day They Were To Be Euthanized Now Looking For Love

NewsBreak

Key Brain Protein Reveals New Insights for Treating Neurological Disorders

Summary: A novel study uncovers how the protein Gephyrin aids in synapse formation, providing new insights into brain connectivity. The findings could help develop treatments for...

Key Brain Protein Reveals New Insights for Treating Neurological Disorders

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