Autism is popularly perceived as a genetic condition that impacts the functioning of various brain mechanisms. The amygdala theory of autism states that autistic individuals differ in the functioning of their amygdala. Researchers suggest more complex differences in a network of structures connected with the amygdala. The amygdala is a...

Autism and the Brain

Houston, TX

Researchers from the University of Houston identified CD8-fit T cells with high motility and serial killing abilities, potentially enhancing T-cell cancer therapies. The study used the TIMING approach and RNA sequencing, revealing molecular signatures that predict positive patient outcomes. A group of cancer researchers from the University of Houston has...

Cancer Breakthrough: Scientists Discover Game-Changing New Type of T Cells

Researchers at St. Jude Children’s Research Hospital and the University of Minnesota have discovered that the aging of T-cells is not constrained by the age of the organism, enabling these healthy cells to continue multiplying indefinitely. Most cell types undergo functional decline after extensive proliferation and replication over the...

Cellular Fountain of Youth: New T-Cell Discovery Rewrites the Rules of Aging

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Fareeha Arshad

A recent study by researchers from Cardiff University and the University of Bristol in the UK sheds light on a genetic variant linked to an increased risk of late-onset Alzheimer's disease. The variant, P460L, affects the EphA1 gene, crucial for cell communication, movement, and development.

Researchers discover a unique link between blood-brain barrier and immune attack

MIT physicists have developed a new form of graphene, creating a five-lane electron superhighway that allows for ultra-efficient electron movement without energy loss. This breakthrough in rhombohedral pentalayer graphene could transform low-power electronic devices and operates via the quantum anomalous Hall effect at zero magnetic field. MIT physicists and their...

MIT Physicists Forge a Five-Lane Quantum Superhighway for Electrons

Medical News Today

A new study reveals a link between gut microbiota and Parkinson's disease, finding that people may have fewer bacteria that produce riboflavin (vitamin B2) and biotin (vitamin B7).

Study suggests 2 vitamin B deficiencies may play a role in Parkinson's disease

Graphene nanolayers are cross-linked with rotaxanes. Graphene, composed of layers of carbon atoms arranged in a honeycomb pattern, is recognized as a supermaterial due to its exceptional conductivity and mechanical advantages. These properties are key to advancing flexible electronics, innovative batteries, and composite materials for aerospace applications. Despite these benefits, creating elastic and durable films has been difficult. In a recent edition of Angewandte Chemie, researchers have proposed a solution by connecting graphene nanolayers through extendable bridging structures, potentially overcoming previous limitations.

Graphene Nanolayers Reinvented: The Key to Advanced Electronics

Total Apex Sports & Entertainment

Do you know anyone who has dual nature? Such two-faced zodiac signs are friendly but they gossip about others behind their backs. They can lie to you without batting an eyelid. However, detecting a two-faced person isn’t easy for everyone. They often compliment their friends when they achieve a goal or change their wardrobe. But they will make negative remarks about you to someone else. What other traits do two-faced people have?

3 Zodiac Signs Who Are Two-Faced

Connecticut Public

About 170 billion cells are in the brain, and as they go about their regular tasks, they produce waste — a lot of it. To stay healthy, the brain needs to wash away all that debris. But how exactly it does this has remained a mystery. Now, two teams...

The brain makes a lot of waste. Now scientists think they know where it goes

Japanese researchers have developed a promising new approach to treating schizophrenia using nanoparticles. This innovative method could potentially restore cognitive decline in patients, addressing a major challenge in current treatments. Overcoming the Blood-Brain Barrier. Schizophrenia, a complex mental health disorder, has long been difficult to treat due to the blood-brain...

Nanoparticle Breakthrough Could Aid Schizophrenia Treatment

Physician scientists from City of Hope, one of the largest cancer research and treatment organizations in the United States, found that people with metastatic kidney cancer who orally took a live biotherapeutic product called CBM588 while in treatment with immunotherapy and enzymatic tyrosine kinase inhibitors experienced improved health outcomes. The phase 1 trial was published today in Nature Medicine.

Changing the gut microbiome improves health outcomes for people new metastatic kidney cancer

Summary: Researchers developed a novel peptide, KS-133, to target cognitive dysfunction in schizophrenia. By using a brain-targeting peptide, KS-487, they successfully transported KS-133 across the blood-brain barrier. Their nanoparticle-based drug delivery system improved cognitive functions in mice, offering a new therapeutic strategy. Key Facts:. KS-133 targets the VIPR2 gene linked...

Peptide Improves Cognition in Schizophrenia

A recent study has discovered that omega-3 fatty acids can significantly reduce symptoms of depression and anxiety in young mice subjected to stress, with the mice exhibiting both behavioral and molecular changes. This finding, published in Neurobiology of Stress, offers hope for new treatments for adolescent depression in humans. Major...

Behavioral and molecular changes in mice suggest omega-3 fatty acids could combat depression

Health

Medically reviewed by Smita Patel, DOMedically reviewed by Smita Patel, DOPOEMS syndrome is a very rare multisystem condition where the body's immune system attacks cells in the nervous system. This attack from the immune system is caused by an abnormal immune response to a cancerous tumor.POEMS syndrome symptoms include weakness of the arms and legs, darkening of the skin, and an abnormal increase in the size of lymph nodes and internal organs like the spleen or liver.POEMS syndrome is a chronic (long-term) disorder with no cure. In the United States, POEMS syndrome affects approximately 5,000 people. The disease occurs 1.5...

POEMS Syndrome

Summary: A novel study uncovers how the protein Gephyrin aids in synapse formation, providing new insights into brain connectivity. The findings could help develop treatments for disorders like autism, epilepsy, and schizophrenia. Researchers used CRISPR-Cas9 to confirm Gephyrin’s role in autonomous synapse development. This breakthrough enhances understanding of synaptic mechanisms...

Key Brain Protein Reveals New Insights for Treating Neurological Disorders

LiveScience

As we sleep, the brain rids itself of waste built up throughout the day. But how?

Does the brain flush out toxins while you sleep?

Changes in how regions of the brain interact with each other, which occur during the surgical procedure for deep brain stimulation (DBS), can temporarily ease motor symptoms of Parkinson’s disease, even before the electrical stimulation is turned on, a study finds. The microlesion effect, as this temporary improvement is...

Brain rewiring eases Parkinson’s symptoms before DBS is turned on

(CN) — Researchers with the American Society for Microbiology think that there may be a link between a chemical metabolized by the bacteria in the digestive system, known as DHPS, and three neurodegenerative diseases. Presented at ASM Microbe, the society's annual meeting, on Sunday, the research is one of...

Sulfur-based metabolites consumed by gut bacteria could be linked to neurodegenerative diseases

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

Researchers have successfully reversed the symptoms of Alzheimer’s disease in mice with a small, synthetic peptide called PHDP5.

Peptide treatment could reverse cognitive decline in Alzheimer's disease

NewsBreak

Revolutionizing Regeneration: Rat Stem Cells Restore Mouse Brain Circuits

Research teams have successfully regenerated mouse brain circuits using rat stem cells, showcasing a new method for restoring brain function and studying interspecies brain development. These...

Revolutionizing Regeneration: Rat Stem Cells Restore Mouse Brain Circuits

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