Study reveals gut bacteria’s role in food addiction and obesity

By Stephen Beech via SWNS

Compulsive eating and obesity may be triggered by a specific gut bacteria, suggests a new study.

The breakthrough may lead to new treatments for the "growing" problem of food addiction and other eating disorders, say scientists.

An international research team has identified specific bacteria in the gut that are associated with both humans and mice developing an addiction to food that can lead to obesity.

The researchers also identified bacteria that play a beneficial role in preventing food addiction.

Professor Elena Martín-García of Pompeu Fabra University, Spain, said: “A number of factors contribute to food addiction, which is characterized by loss of control over food intake and is associated with obesity, other eating disorders and alterations in the composition of bacteria in the gut – the gut microbiome.

"Until now, the mechanisms underlying this behavioral disorder were largely unknown.”

The research is due to be presented on Thursday at the Federation of European Neuroscience Societies (FENS) Forum in Vienna, Austria, and will published simultaneously in the journal Gut .

Dr. Rafael Maldonado , who leads the Laboratory of Neuropharmacology at Pompeu Fabra University, said: “These results from our study may allow us to identify new biomarkers for food addiction and, most importantly, to evaluate whether the beneficial bacteria could be used as potential new treatments for this obesity-related behavior, which, at present, lacks any effective therapeutic approaches.

"Potential new treatments could involve using beneficial bacteria and dietary supplementation.”

Prof. Martín-García used the Yale Food Addiction Scale (YFAS 2.0) to diagnose food addiction in mice and humans.

It contains 35 questions for people to answer, and these can also be grouped into three criteria for use in mice: persistent food-seeking, high motivation to obtain food, and compulsive behavior.

She and her colleagues investigated the gut bacteria in mice who were and were not addicted to food and found an increase in bacteria belonging to a group called the Proteobacteria phylum and a decrease in bacteria belonging to the Actinobacteria phylum in the food-addicted mice.

Those mice also had a decrease in the amount of another type of bacteria called Blautia from the Bacillota phylum.

The researchers used the YFAS to classify 88 patients into those who were addicted or not addicted to food.

Similar to the findings in mice, decreases in Actinobacteria phylum and Blautia were seen in those who were food-addicted and increases in Proteobacteria phylum.

Further analysis showed how the findings in humans correlated with those in mice.

Prof. Martín-García said: “The findings in both mice and humans suggested that specific microbiota could be protective in preventing food addiction.

"In particular, the strong similarities in the amount of Blautia underlined the potential beneficial effects of this particular gut bacteria.

"Therefore, we investigated the protective effects of oral administration of lactulose and rhamnose, which are non-digestible carbohydrates known as ‘prebiotics’ that can increase the amount of Blautia in the gut.

"We did this in mice and found that it led to an increase in the abundance of Blautia in mice faeces in parallel with dramatic improvements in food addiction.

"We saw similar improvements when we gave the mice a species of Blautia called Blautia wexlerae orally as a probiotic.

“The gut microbiota signatures in both mice and humans suggest possible non-beneficial effects of bacteria belonging to the Proteobacteria phylum and potential protective effects of increasing the abundance of Actinobacterial and Bacillota against the development of food addiction.”

Prof. Martín-García says the findings show how bacteria in the gut influence brain function and vice versa.

She said: “We have demonstrated for the first time a direct interaction between the gut composition and brain gene expression, revealing the complex and multifactorial origin of this important behavioural disorder related to obesity.

"Understanding the crosstalk between alterations in behaviour and bacteria in the gut constitutes a step forward for future treatments for food addiction and related eating disorders.”

Prof. Martín-García also described work investigating how microRNAs (miRNAs) – small, single-stranded molecules that regulate gene expression and contribute to almost any cellular process – are involved in food addiction.

She says changes in the expression of miRNAs may be involved in the mechanisms underlying the disorder.

The researchers used a technique called Tough Decoy (TuD) to inhibit specific miRNAs in the medial prefrontal cortex (mPFC) of brains of mice in order to produce mice that were vulnerable to developing food addiction.

They explained that the mPFC is the part of the brain involved in self-control and decision-making.

They found that inhibition of miRNA-29c-3p promoted persistence of response and enhanced the vulnerability of the mice to develop food addiction.

Inhibiting another miRNA called miRNA-665-3p promoted compulsive behaviour and vulnerability to food addiction.

Dr. Maldonado said: “These two miRNAs could act as protective factors against food addiction.

"This helps us to understand the neurobiology of the loss of eating control, which plays a crucial role in obesity and related disorders.

"To understand these mechanisms further, we are now exploring how the gut microbiota and miRNA expression in the brain interact in mice.”

Chair of the FENS communication committee Dr. Richard Roche welcomed the findings.

Dr. Roche, of Maynooth University, Ireland, who was not involved in the research, said: “Compulsive eating and food addiction is a growing problem worldwide.

"There are many factors that contribute to it, in particular the environment that people live in and the availability of certain types of food.

"However, we’ve known for some time that there are probably contributing factors for eating disorders and the research by Professor Martín-García and colleagues shows how the different types of bacteria in the gut have an impact on brain function and vice versa in humans and mice."

He added: "This understanding opens the way to developing potential new treatments for eating disorders, and we look forward to seeing more research in this area.”

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