Ohtuvayre - an inhaled bronchodilator with non-steroidal anti-inflammatory effects - is the first new mechanism in COPD approved in more than 20 years. Verona Pharma announced yesterday the FDA approval of Ohtuvayre (ensifentrine) for treating chronic obstructive pulmonary disease (COPD) in adult patients, according to a press release. Ohtuvayre is...

FDA Approval Granted for Novel COPD Treatment

Pictured: Lungs over a background of the FDA and a man with a mask/Nicole Bean for BioSpace. Patients with chronic obstructive pulmonary disease may soon have a new treatment option with fewer side effects as Verona Pharma prepares for a potential approval this week. Wednesday, the FDA is set to...

Verona Gears Up for First Novel COPD Approval in Over a Decade

(Reuters) -The U.S. Food and Drug Administration has granted approval to a treatment from Verona Pharma for a chronic lung disease that commonly affects smokers, the U.K.-based company said on Wednesday. U.S.-listed shares of the company surged 11% in extended trading. The U.S. FDA's assent for the therapy, to be...

US FDA Approves Verona Pharma's Inhaled COPD Therapy

Ensifentrine, a PDE3 and 4 inhibitor from Verona Pharma, was associated with significantly improved lung function and reduced COPD exacerbations over 24 weeks. The US Food and Drug Administration (FDA) has approved ensifentrine (Ohtuvayre) for the treatment of patients with chronic obstructive pulmonary disease (COPD).1. Ensifentrine, an inhaled nonsteroidal nebulizer...

FDA Approves Ensifentrine (Ohtuvayre) for COPD

Everyday Health

The medication combines the effects of a bronchodilator and anti-inflammatory drug to ease symptoms like coughing, wheezing, and shortness of breath.

New COPD Drug Is a True Multitasker

If you notice changes in the typical symptoms associated with COPD, it may be a sign of an exacerbation, or of disease progression.

7 Signs Your COPD Is Getting Worse

Ohtuvayre is the first inhaled product with a novel mechanism of action for chronic obstructive pulmonary disease to be approved in 20 years. The FDA has approved Verona Pharma’s Ohtuvayre (ensifentrine) for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adult patients. Classified as a first-in-class selective dual inhibitor of phosphodiesterase 3 and 4 (PDE3 and PDE4), the treatment combines bronchodilator and non-steroidal anti-inflammatory effects in one molecule. According to the company, this marks the first time in 20 years that an inhaled product with a novel mechanism of action has been approved for COPD maintenance.1.

FDA Approves Verona’s Ohtuvayre for the Maintenance Treatment of Chronic Obstructive Pulmonary Disease

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

Patients who received long-acting injectable antipsychotics (LAIs) in the hospital but discontinued them early faced a 22% to 25% higher readmission risk than those who did not receive LAIs. Results from a new study suggest that patients with schizophrenia experiencing their first hospitalization face a significantly higher risk of readmission...

Early Discontinuation of LAIs in Schizophrenia Linked to Higher Readmission Rates

Health

Medically reviewed by Smita Patel, DOMedically reviewed by Smita Patel, DOPOEMS syndrome is a very rare multisystem condition where the body's immune system attacks cells in the nervous system. This attack from the immune system is caused by an abnormal immune response to a cancerous tumor.POEMS syndrome symptoms include weakness of the arms and legs, darkening of the skin, and an abnormal increase in the size of lymph nodes and internal organs like the spleen or liver.POEMS syndrome is a chronic (long-term) disorder with no cure. In the United States, POEMS syndrome affects approximately 5,000 people. The disease occurs 1.5...

POEMS Syndrome

Community Voices represent independent, third-party users who have joined our contributor program but not yet verified their accounts. Community Voices are expected, like all users, to adhere to our Community Standards.

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Total Apex Sports & Entertainment

People have different levels of maturity. An individual’s age or upbringing can make them possess certain traits. Yet, most people believe that one matures as they grow old. On the contrary, some zodiac signs appear childish in old age. They are jumpy and careless. This strains their relationships with signs who misunderstand them. Air and fire signs are temperamental and some people refer to them as being childish. How can you identify an immature sign?

3 Zodiac Signs Who Are Immature

Results from three randomized clinical trials show safety and efficacy of a brexpiprazole-sertraline combination in adult patients with post-traumatic stress disorder. The FDA has accepted Otsuka and Lunbdeck’s supplemental New Drug Application for brexpiprazole in combination with sertraline for the treatment of adults with post-traumatic stress disorder (PTSD). The sNDA is supported by data from three randomized clinical trials that evaluated the safety and efficacy of the brexpiprazole-sertraline combination in adult patients with PTSD.1.

FDA Accepts Otsuka and Lundbeck’s Supplemental New Drug Application for Brexpiprazole to Treat Adults with Post-Traumatic Stress Disorder

California State

Contributors represent independent, third-party users who have joined our contributor program and self-verified their accounts. They have also demonstrated their experience writing hard news for other outlets. Contributors are expected, like all users, to adhere to our Community Standards.

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Alameda Post

California regulators just stopped AT&T from pulling the plug. California’s Public Utilities Commission on June 20 rejected AT&T’s application to stop providing landlines and other services in areas where there is no other option.

Still Need Your Landline?

Newark, NJ

Morristown Minute

NEWARK, N.J. – Eight individuals associated with the "793 Bloods" street gang, a subset of the national Bloods gang, have been charged for their roles in a Newark-based drug trafficking organization, U.S. Attorney Philip R. Sellinger announced.

Eight '793 Bloods' Gang Members Charged in Newark Drug Network

(Reuters) - Eli Lilly (NYSE:LLY) on Friday said its popular weight-loss drug Zepbound helped resolve moderate to severe obstructive sleep apnea in up to 52% of patients in two late-stage trials. U.S.-based Lilly and Danish rival Novo Nordisk (NYSE:NVO) are in a race to get their obesity drugs approved to...

Weight-loss drug Zepbound resolves sleep apnea in up to 52% of patients, Lilly says

Approval of Skyrizi marks the first IL-23 specific inhibitor approved for both ulcerative colitis and Crohn disease of similar severity, according to AbbVie. The FDA has approved AbbVie’s Skyrizi (risankizumab-rzaa) for the treatment for adults with moderately to severely active ulcerative colitis (UC). According to the company, this approval makes Skyrizi the first IL-23 specific inhibitor to be approved for both UC and Crohn disease classified as moderate-to-severe. The approval was based on results from the INSPIRE Induction study and the COMMAND Maintenance study. In addition to the approved indications for UC and Crohn disease, Skyrizi also has been approved for active psoriatic arthritis and plaque psoriasis.1.

FDA Approves AbbVie’s Skyrizi for the Treatment of Adults with Moderate to Severely Active Ulcerative Colitis

COPD can impact your ability to work. Here's how to talk to your employer about COPD, ask for reasonable accommodations, and recognize when it might be time to switch jobs or retire.

Managing COPD in the Workplace

Declutterbuzz

Why Depression Can Impact A Cluttered Home & Cluttered Mind sets out to explain the possible connection between depression and clutter. Scientists that study depression have found a link to depression playing a role in some folks.

Why Depression Can Impact A Cluttered Home & Cluttered Mind

Diabetes drugs known as GLP-1 agonists are linked to a lower risk of dementia compared to other diabetes drugs known as sulfonylureas and DPP-4 inhibitors. As type 2 diabetes increases a person’s risk of dementia, the findings may help inform treatment options for patients with diabetes. The corresponding study was published in eClinicalMedicine.

Diabetes Drug Show Promise for Reducing Dementia Risk

Among individuals with primary biliary cholangitis (PBC), pruritus and fatigue are the most common symptoms of the disorder, with research warranted to elucidate the pathophysiology of the disease, as well as to assess effective treatments for improving patient survival and quality of life (QoL). The current review, published recently in...

Pruritus, Fatigue Most Common Symptoms in PBC, Need Treatment Options

NewsBreak

What the Ensifentrine FDA Approval Means for COPD

In this HCPLive Special Report, experts review ensifentrine's role as a novel maintenance therapy for COPD. In the opening segment of this HCPLive Special Report –...

What the Ensifentrine FDA Approval Means for COPD

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