Metformin, a medication commonly used to treat type 2 diabetes, helps the body regulate sugar in the bloodstream. Part of the class of drugs known as biguanides, metformin reduces the amount of sugar you absorb from food and the amount produced by the liver. Metformin also impacts the way the body will respond to insulin, the natural substance that regulates blood sugar levels.

Diabetes Drug Metformin Investigated for Cancer Prevention Use

BGR.com

GSK announced a major breakthrough concerning cancer therapy. A drug called Jemperli (dostarlimab) showed impressive results in a phase 2 trial at the Memorial Sloan Kettering Cancer Center (MSK). The study included 42 patients suffering from mismatch repair deficient (dMMR) locally advanced rectal cancer, a type of bowel cancer.
Used as a first-line treatment and an alternative to chemotherapy and surgery, Jemperli cured cancer in all patients, showing “an unprecedented 100% clinical complete response rate.” Tests that followed showed no evidence of remaining tumors. Moreover, the first 24 of the 42 patients were observed after an average time of 26.3 months,...

New bowel tumor drug helped cure cancer in 100% of cases

Researchers at St. Jude Children’s Research Hospital and the University of Minnesota have discovered that the aging of T-cells is not constrained by the age of the organism, enabling these healthy cells to continue multiplying indefinitely. Most cell types undergo functional decline after extensive proliferation and replication over the...

Cellular Fountain of Youth: New T-Cell Discovery Rewrites the Rules of Aging

Cancer Health

Since his diagnosis with incurable Stage IV brain cancer in 2023, Australian doctor Richard Scolyer revealed that he has been cancer-free for a year after undergoing a world-first treatment based on his own research on immunotherapy to treat melanoma, a type of skin cancer, according to BBC. Last year, following...

Doctor Is Cancer-Free Following World-First Treatment He Developed

Seattle, WA

SurvivorNet

Raquel A. was diagnosed with colorectal cancer at age 33 after experiencing increased and abnormal bowel movements—symptoms she dismissed as a food intolerance or irritable bowel syndrome (IBS), a debilitating condition impacting the stomach and manifesting in symptoms such as diarrhea and constipation, which actress Kirsten Dunst understand all too well.

Seattle Tech Worker, 33, Discovers Food Intolerance Symptoms Are Actually Colon Cancer —

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NewSantaAna

The FBI has seen a rise in scams targeting timeshare owners. In this kind of scam, criminals con these part-time property owners into shelling out hefty sums of cash, all under false pretenses related to their timeshare properties.

FBI warns that Mexican cartels are targeting Americans with timeshare scams

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Fareeha Arshad

In a recent study from China, researchers have revealed a potential dual benefit of a new antidepressant in combating both depression and certain types of cancer. Ansofaxine hydrochloride, an oral antidepressant, has shown promise in inhibiting the growth of colon cancer cells in both cell cultures and mice. When combined strategically with anti-tumour drugs, ansofaxine hydrochloride bolsters the immune system and triggers programmed cell death in cancer cells.

New Antidepressant Shows Dual Promise in Fighting Depression and Colon Cancer

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

Houston, TX

Researchers from the University of Houston identified CD8-fit T cells with high motility and serial killing abilities, potentially enhancing T-cell cancer therapies. The study used the TIMING approach and RNA sequencing, revealing molecular signatures that predict positive patient outcomes. A group of cancer researchers from the University of Houston has...

Cancer Breakthrough: Scientists Discover Game-Changing New Type of T Cells

Spinal meningitis, more commonly known as meningitis, is inflammation of the meninges, the membranes surrounding the brain and spinal cord. It is a serious and potentially life threatening condition. The symptoms, treatment options, and outlook for patients with spinal meningitis can vary depending on the cause of the infection. The...

What is spinal meningitis?

Japanese researchers have developed a promising new approach to treating schizophrenia using nanoparticles. This innovative method could potentially restore cognitive decline in patients, addressing a major challenge in current treatments. Overcoming the Blood-Brain Barrier. Schizophrenia, a complex mental health disorder, has long been difficult to treat due to the blood-brain...

Nanoparticle Breakthrough Could Aid Schizophrenia Treatment

Medical News Today

A new cell study has shown the common type 2 diabetes medication metformin alters levels of microRNAs that target genes to slow down the growth and multiplication of colorectal cancer cells. The researchers say their findings could lead to new RNA therapeutics for cancer prevention and treatment.

Metformin slows colorectal cancer growth using microRNAs, study finds

The following is a summary of “Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo,” published in the April 2024 issue of Psychiatry by Sportelli et al. The genetic basis of schizophrenia involves multiple pathways related to synaptic function, but how these...

Understanding Brain Dopamine Pathways and Schizophrenia Genetics

Health

Medically reviewed by Smita Patel, DOMedically reviewed by Smita Patel, DOPOEMS syndrome is a very rare multisystem condition where the body's immune system attacks cells in the nervous system. This attack from the immune system is caused by an abnormal immune response to a cancerous tumor.POEMS syndrome symptoms include weakness of the arms and legs, darkening of the skin, and an abnormal increase in the size of lymph nodes and internal organs like the spleen or liver.POEMS syndrome is a chronic (long-term) disorder with no cure. In the United States, POEMS syndrome affects approximately 5,000 people. The disease occurs 1.5...

POEMS Syndrome

CBS Boston

BOSTON - There currently is no cure for Parkinson's disease, but scientists may have discovered a potential path to slow or stop the disease.Parkinson's disease is a brain disorder that can cause movement problems such as tremors, poor balance, and walking difficulties, and it can also impair cognitive function.  There is no cure and treatments aim to simply reduce symptoms. But a new study in mice by researchers at Johns Hopkins offers new hope.  They found that the interaction of two proteins is key to the buildup of protein clumps in the brain that damage healthy brain cells in Parkinson's. They also suggest that disrupting these proteins with a drug already approved by the FDA to treat cancer could potentially slow or stop the brain damage associated with Parkinson's.  The next step would be to conduct clinical trials in humans, but that will take time.  


Drug used for cancer treatment could help slow or stop Parkinson's, study says

The signs that thyroid cancer has spread can vary depending on where in the body it has traveled to. Thyroid cancers often spread to the nearby lymph nodes and the lungs, bone, brain, and liver. For all types of thyroid cancer, early detection and personalized treatment plans are crucial for...

What are some signs that thyroid cancer has spread?

Summary: A novel study uncovers how the protein Gephyrin aids in synapse formation, providing new insights into brain connectivity. The findings could help develop treatments for disorders like autism, epilepsy, and schizophrenia. Researchers used CRISPR-Cas9 to confirm Gephyrin’s role in autonomous synapse development. This breakthrough enhances understanding of synaptic mechanisms...

Key Brain Protein Reveals New Insights for Treating Neurological Disorders

A person can have thyroid cancer for months or years without experiencing any symptoms. Symptoms may not develop until the cancer advances. The thyroid is a gland at the base of the throat that sends out hormones to control blood pressure, heart rate, metabolism, and body temperature. Thyroid cancers develop...

How long can a person have thyroid cancer without knowing it?

Black Coffee and Blue Jeans

Thyroid cancer is a type of cancer that originates in the thyroid gland, a butterfly-shaped gland located at the base of the neck, just below the Adam's apple. The thyroid gland produces hormones that regulate heart rate, blood pressure, body temperature, and your weight. There are several types of thyroid cancer, to include: Papillary Thyroid Cancer, (the most common type), Follicular Thyroid Cancer, hurthle cell cancer, Medullary Thyroid Cancer, , and Anaplastic Thyroid Cancer, the rarest type but most aggressive, and thyroid lymphoma.

Thyroid Cancer: Risks, Symptoms & Treatments

New York State

NBC News

Stephen Munari donated a kidney to his son Jaren who has branchio-oto-renal syndrome, a rare condition that affects the kidneys, neck and ears. Doctors said that Jaren would need a kidney transplant right away and his dad Stephen was a perfect match.

New York father donates kidney to son with rare condition

NewsBreak

Stopping Measles Cold: Groundbreaking Insights From Cryo-EM

Researchers uncovered exactly how a neutralizing antibody blocks measles virus infection and are using that knowledge to develop new vaccines and treatments to inhibit the measles...

Stopping Measles Cold: Groundbreaking Insights From Cryo-EM

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