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NewSantaAna

The FBI has seen a rise in scams targeting timeshare owners. In this kind of scam, criminals con these part-time property owners into shelling out hefty sums of cash, all under false pretenses related to their timeshare properties.

FBI warns that Mexican cartels are targeting Americans with timeshare scams

Ohtuvayre is the first inhaled product with a novel mechanism of action for chronic obstructive pulmonary disease to be approved in 20 years. The FDA has approved Verona Pharma’s Ohtuvayre (ensifentrine) for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adult patients. Classified as a first-in-class selective dual inhibitor of phosphodiesterase 3 and 4 (PDE3 and PDE4), the treatment combines bronchodilator and non-steroidal anti-inflammatory effects in one molecule. According to the company, this marks the first time in 20 years that an inhaled product with a novel mechanism of action has been approved for COPD maintenance.1.

FDA Approves Verona’s Ohtuvayre for the Maintenance Treatment of Chronic Obstructive Pulmonary Disease

Approval of Epkinly was based on results from the Phase I/II EPCORE trial in patients with relapsed or refractory follicular lymphoma who have already completed two or more lines of systemic therapy. The FDA has approved Genmab A/S and AbbVie's Epkinly (epcoritamab-bysp) for the treatment of adults with relapsed or...

FDA Approves Genmab’s Epkinly to Treat Adults with Relapsed or Refractory Follicular Lymphoma After Two or More Lines of Systemic Therapy

Approval of Skyrizi marks the first IL-23 specific inhibitor approved for both ulcerative colitis and Crohn disease of similar severity, according to AbbVie. The FDA has approved AbbVie’s Skyrizi (risankizumab-rzaa) for the treatment for adults with moderately to severely active ulcerative colitis (UC). According to the company, this approval makes Skyrizi the first IL-23 specific inhibitor to be approved for both UC and Crohn disease classified as moderate-to-severe. The approval was based on results from the INSPIRE Induction study and the COMMAND Maintenance study. In addition to the approved indications for UC and Crohn disease, Skyrizi also has been approved for active psoriatic arthritis and plaque psoriasis.1.

FDA Approves AbbVie’s Skyrizi for the Treatment of Adults with Moderate to Severely Active Ulcerative Colitis

Reading, PA

Mahanoy City, PA

The Shenandoah (PA) Sentinel

MAHANOY CITY – Two members of a motorcycle club were convicted on federal charges, accused...
The post Convicted motorcycle club members orchestrated ‘brutal’ home-invasion in Mahanoy, feds say first appeared on The Shenandoah Sentinel.

Convicted motorcycle club members orchestrated ‘brutal’ home-invasion in Mahanoy, feds say

Health

Reviewed by Ivy Kwong, LMFTReviewed by Ivy Kwong, LMFTIrritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are two chronic gastrointestinal disorders that share some overlapping symptoms, like abdominal pain, bloating, and diarrhea. While IBS and IBD have similar symptoms and acronyms, they are two distinct conditions with different underlying causes and treatment approaches. IBS is a functional disorder, meaning it affects how the intestines work but doesn't cause inflammation. IBD is an inflammatory disease that damages the gastrointestinal (GI) tract. In the United States, IBS affects between 25-45 million people, and IBD affects more than 3 million people.Symptoms of IBS vs....

What Is the Difference Between Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD)?

Newark, NJ

Morristown Minute

NEWARK, N.J. – Eight individuals associated with the "793 Bloods" street gang, a subset of the national Bloods gang, have been charged for their roles in a Newark-based drug trafficking organization, U.S. Attorney Philip R. Sellinger announced.

Eight '793 Bloods' Gang Members Charged in Newark Drug Network

Georgia State

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Coffee County, GA

Douglas, GA

Daily Coffee Press

A 49-year-old woman from Douglas was recently arrested for allegedly submitting a life insurance policy for her ex-husband without his knowledge. According to a Coffee County Sheriff’s Office incident report, detectives met with a man on May 7 at the Coffee County Law Enforcement Center concerning a reported case of insurance fraud.

Georgia woman charged for allegedly filing life insurance policy application on ex-husband

Gloucester County, NJ

Franklinville, NJ

FRANKLINVILLE, N.J. -A Gloucester County, New Jersey, man admitted today that he defrauded the government of more than $200,000 in Social Security and Medicaid benefits, U.S. Attorney Philip R. Sellinger announced.

Man Guilty of $200K Social Security & Medicaid Fraud

Ali Carney, 46, of Newark, received a 65-month prison sentence for conspiring to distribute narcotics, including fentanyl and heroin, and possessing with intent to distribute fentanyl, according to U.S. Attorney Philip R. Sellinger.

Gang Member Sentenced to 65 Months for Drug Trafficking

Denver, CO

David Heitz

The mother of a Denver homeless man told the City Council Monday that city-sponsored services have failed her son. Barbara Hallick Yeomans made her remarks during public comment period of the City Council meeting. She said her son grapples with substance abuse and mental illness and repeatedly has been harassed by police. She said her son also suffered verbal abuse by a guard in the Denver County Jail. Yeomans said she heard the guard harassing her son over the phone.

Mother says Denver homeless services have failed her son

Douglas City, CA

This afternoon, Kentaiwon Durham, the Douglas City Commissioner of Ward 2, entered a guilty plea for wire fraud in the U.S. District Court for the Southern District of Georgia. Consequently, Durham is mandated to resign from his position as a city commissioner.

Georgia City Commissioner Pleads Guilty to Wire Fraud in $20K PPP Fraud Scheme

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

Japanese researchers have developed a promising new approach to treating schizophrenia using nanoparticles. This innovative method could potentially restore cognitive decline in patients, addressing a major challenge in current treatments. Overcoming the Blood-Brain Barrier. Schizophrenia, a complex mental health disorder, has long been difficult to treat due to the blood-brain...

Nanoparticle Breakthrough Could Aid Schizophrenia Treatment

Coming into ASCO 2024, what would you consider the largest unmet needs in treating and managing melanoma?. What are the latest trends and innovations you have observed in treating and managing melanoma leading up to and coming out of ASCO 2024?

ASCO 2024: Addressing Unmet Needs in Melanoma Treatment and Management

New Jersey State

NEWARK, N.J. – Naiem Moore, 34, of Newark, admitted to possessing cocaine and heroin for distribution and illegally possessing a firearm as a convicted felon, U.S. Attorney Philip R. Sellinger announced. Moore entered his guilty plea before U.S. District Judge Madeline Cox Arleo in Newark federal court.

Man Admits Drug Trafficking & Illegal Firearm Possession

Clark County, WA

Timothy A Gruver

Dentist Ellis B. Jardine of Clark County has been suspended for allegedly practicing outside the scope of his licenses and subpar care, the Washington State Department of Health reported on Friday.

Dentist Suspended for Subpar Care & Unlicensed Practices

Various improvements were seen in 2 adult patients and 2 pediatric patients treated in separate clinical trials. Taysha Gene Therapies’ TSHA-102, an investigational adeno-associated virus (AAV) vector-based gene therapy, has continued to generate positive efficacy and safety data in updated results from the phase 1/2 REVEAL adolescent and adult clinical trial (NCT05606614) and the separate phase 1/2 REVEAL Pediatric Study clinical trial (NCT06152237).1.

Taysha’s Rett Syndrome Gene Therapy TSHA-102 Continues to Show Promise in Adult and Pediatric Patients

California State

Alameda Post

California regulators just stopped AT&T from pulling the plug. California’s Public Utilities Commission on June 20 rejected AT&T’s application to stop providing landlines and other services in areas where there is no other option.

Still Need Your Landline?

Pennsylvania State

NEW JERSEY – Attorney General Matthew J. Platkin, along with the Division on Civil Rights (DCR), has co-led a multistate comment letter supporting the U.S. Department of Housing and Urban Development’s (HUD) proposed rule aimed at reducing criminal history-based barriers to public housing. This initiative is a collaborative effort with the Attorneys General of Maryland, Massachusetts, and Pennsylvania to improve access to safe and affordable housing.

HUD Rule Fights Housing Barriers for Ex-Offenders

NewsBreak

Johnson & Johnson Boosts Bispecifics Portfolio with Proteologix Acquisition

With the Proteologix acquisition, Johnson & Johnson gains two bispecific antibody early phase assets for immune-mediated diseases. Johnson & Johnson has completed its $850 million acquisition...

Johnson & Johnson Boosts Bispecifics Portfolio with Proteologix Acquisition

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