The following is a summary of “Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo,” published in the April 2024 issue of Psychiatry by Sportelli et al. The genetic basis of schizophrenia involves multiple pathways related to synaptic function, but how these...

Understanding Brain Dopamine Pathways and Schizophrenia Genetics

Japanese researchers have developed a promising new approach to treating schizophrenia using nanoparticles. This innovative method could potentially restore cognitive decline in patients, addressing a major challenge in current treatments. Overcoming the Blood-Brain Barrier. Schizophrenia, a complex mental health disorder, has long been difficult to treat due to the blood-brain...

Nanoparticle Breakthrough Could Aid Schizophrenia Treatment

Patients who received long-acting injectable antipsychotics (LAIs) in the hospital but discontinued them early faced a 22% to 25% higher readmission risk than those who did not receive LAIs. Results from a new study suggest that patients with schizophrenia experiencing their first hospitalization face a significantly higher risk of readmission...

Early Discontinuation of LAIs in Schizophrenia Linked to Higher Readmission Rates

Summary: A novel study uncovers how the protein Gephyrin aids in synapse formation, providing new insights into brain connectivity. The findings could help develop treatments for disorders like autism, epilepsy, and schizophrenia. Researchers used CRISPR-Cas9 to confirm Gephyrin’s role in autonomous synapse development. This breakthrough enhances understanding of synaptic mechanisms...

Key Brain Protein Reveals New Insights for Treating Neurological Disorders

Upworthy

Do you often walk into a room and forget why you are there? Or when you sit down to read a book, do you end up reading the same paragraph over and over? If you experience these things frequently, you may be worried that your cognitive function is declining.The brain structure changes and shrinks as we get older, which can result in minor cognitive decline. However, frequent disorientation, forgetfulness, and difficulty making decisions can be signs of serious cognitive impairment—such as dementia or Alzheimer’s disease—that significantly interferes with daily activities and reduces quality of life.Fortunately, there are some measures you...

Boost your Brain: Lifestyle changes that enhance cognitive function in adults

Autism is popularly perceived as a genetic condition that impacts the functioning of various brain mechanisms. The amygdala theory of autism states that autistic individuals differ in the functioning of their amygdala. Researchers suggest more complex differences in a network of structures connected with the amygdala. The amygdala is a...

Autism and the Brain

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Total Apex Sports & Entertainment

Specific zodiac signs in astrology are viewed as homebodies due to the natural traits associated with their astrological profiles. These traits influence their preferences and comfort zones. The homebody tendencies of these zodiac signs develop out of their internal need for comfort, security, and personal space.

4 Zodiac Signs Who Love Staying In

Vitamin B12 deficiency is common. It can lead to various health issues, affecting everything from energy levels to brain function. Vitamin B12, or cobalamin, is an essential nutrient in meat, fish, and dairy products. It is crucial for red blood cell production and a healthy nervous system. When B12 levels...

Unusual symptoms of B12 deficiency

(CN) — Researchers with the American Society for Microbiology think that there may be a link between a chemical metabolized by the bacteria in the digestive system, known as DHPS, and three neurodegenerative diseases. Presented at ASM Microbe, the society's annual meeting, on Sunday, the research is one of...

Sulfur-based metabolites consumed by gut bacteria could be linked to neurodegenerative diseases

The Healthy 

Statins rank as some of the most frequently prescribed medications in the United States—the Cleveland Clinic says 92 million U.S. adults take statins to lower their risk of cardiovascular complications, especially those with high cholesterol, diabetes, or existing heart conditions. Statins prevent cardiovascular diseases, including heart attacks and strokes, by inhibiting a key enzyme the liver uses to produce cholesterol.

Do Statins Cause Dementia? Cardiology and Brain Experts Respond

According to a new study, it was found that higher estrogen receptor density could tell whether a woman is premenopausal or postmenopausal, and that it’s related to lower memory scores and mood and cognitive issues in postmenopausal women. As women go through menopause, the amount of estrogen receptors (ER)...

Menopause Increases Brain Estrogen Receptors, Affecting Memory and Mood

Summary: Researchers discovered the serotonin 2C receptor in the brain plays a crucial role in regulating memory in both humans and animal models. This breakthrough offers insights into conditions associated with memory loss, such as Alzheimer’s disease, and suggests new treatment pathways. Mutations in the serotonin 2C receptor gene...

Serotonin 2C Receptor Key to Memory

Medical News Today

A new study reveals a link between gut microbiota and Parkinson's disease, finding that people may have fewer bacteria that produce riboflavin (vitamin B2) and biotin (vitamin B7).

Study suggests 2 vitamin B deficiencies may play a role in Parkinson's disease

A recent study published in Nature Mental Health has shed light on the brain’s potential for recovery in individuals with heroin addiction undergoing inpatient treatment. The research, which focused on the brain’s inhibitory control processes, found significant improvements in brain activity related to self-control following 15 weeks of inpatient treatment. These findings offer hope for more effective interventions in addressing heroin addiction.

Study finds improved brain function in heroin addicts after 15 weeks of treatment

Summary: Researchers identified unique molecular signatures of blood-brain barrier dysfunction in Alzheimer’s disease. They discovered altered communication between brain vascular cells mediated by VEGFA and SMAD3 molecules. These findings could lead to new diagnostic biomarkers and treatment options for Alzheimer’s. Key Facts:. VEGFA and SMAD3 play crucial roles...

New Molecular Signatures Found for Alzheimer’s Disease

Everyday Health

A new study links parental Alzheimer's to greater build-up of amyloid plaques in the brains of adult children, with maternal history posing greater risk than paternal history.

Your Dementia Risk May Increase if Your Mother Has Alzheimer's

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

Vitamin D could be beneficial as part of the therapeutic scheme for patients with myasthenia gravis (MG), according to a study recently published in BMC Neurology. “While this article constitutes a single case report and thus cannot furnish conclusive evidence for clinical practice, it suggests that physicians should consider monitoring and supplementing vitamin D levels in patients exhibiting MG symptoms following gastrointestinal surgery,” the authors wrote.

Vitamin D Supplementation Shows Promise in Treating MG

A recent study has discovered that omega-3 fatty acids can significantly reduce symptoms of depression and anxiety in young mice subjected to stress, with the mice exhibiting both behavioral and molecular changes. This finding, published in Neurobiology of Stress, offers hope for new treatments for adolescent depression in humans. Major...

Behavioral and molecular changes in mice suggest omega-3 fatty acids could combat depression

Istradefylline led to significant reductions in tremor and motor symptoms in patients with Parkinson disease over 24 weeks. Interim data from a 6-month, open-label, single arm exploratory pilot study showed that istradefylline (Nourianz; Kyowa Kirin), an FDA-approved adjunctive treatment for OFF episodes in Parkinson disease (PD), may have positive benefits on treating tremor in this patient population. Additional findings and final analysis will be incoming for all patients who completed the study, including tremor amplitude scores utilizing the MindSquare app.1.

Istradefylline Shows Promising Effects as Treatment for Tremor in Parkinson Disease

NewsBreak

Peptide Improves Cognition in Schizophrenia

Summary: Researchers developed a novel peptide, KS-133, to target cognitive dysfunction in schizophrenia. By using a brain-targeting peptide, KS-487, they successfully transported KS-133 across the blood-brain...

Peptide Improves Cognition in Schizophrenia

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