Columbus, OH

Summary: A novel study uncovers how the protein Gephyrin aids in synapse formation, providing new insights into brain connectivity. The findings could help develop treatments for disorders like autism, epilepsy, and schizophrenia. Researchers used CRISPR-Cas9 to confirm Gephyrin’s role in autonomous synapse development. This breakthrough enhances understanding of synaptic mechanisms...

Key Brain Protein Reveals New Insights for Treating Neurological Disorders

The Mirror US

A new trial found that medication, Sildenafil sold under the brand name, Viagra improves brain flow and could help prevent dementia.

Common erectile dysfunction pill could help prevent dementia, 'pivotal' study suggests

The Healthy 

Statins rank as some of the most frequently prescribed medications in the United States—the Cleveland Clinic says 92 million U.S. adults take statins to lower their risk of cardiovascular complications, especially those with high cholesterol, diabetes, or existing heart conditions. Statins prevent cardiovascular diseases, including heart attacks and strokes, by inhibiting a key enzyme the liver uses to produce cholesterol.

Do Statins Cause Dementia? Cardiology and Brain Experts Respond

Article written by Emily Spencer, Edinburgh Napier University. Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. This might sound like science fiction, but innovative new research is making it a potential reality. Scientists have discovered that when mice with...

Alzheimer’s patients could protect memory simply by inhaling menthol, mouse study shows

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Total Apex Sports & Entertainment

Do you know anyone who has dual nature? Such two-faced zodiac signs are friendly but they gossip about others behind their backs. They can lie to you without batting an eyelid. However, detecting a two-faced person isn’t easy for everyone. They often compliment their friends when they achieve a goal or change their wardrobe. But they will make negative remarks about you to someone else. What other traits do two-faced people have?

3 Zodiac Signs Who Are Two-Faced

Summary: Researchers reversed Alzheimer’s symptoms in mice using a synthetic peptide, PHDP5, that targets brain function. The study shows that PHDP5 can cross the blood-brain barrier and restore memory by improving synaptic function. The treatment could delay cognitive decline if administered early. This breakthrough paves the way for new...

Synthetic Peptide Reverses Alzheimer’s Symptoms

ScienceAlert


A new study highlights how drinking more than three cups of  coffee a day affects dopamine levels in the brains of people with Parkinson's, a finding that potentially influence how we monitor and perhaps one day treat the disease.



					
			

The research, led by a team from the University of Turku and Turku University Hospital in Finland, was undertaken to fill in a specific knowledge gap: how coffee consumption affects people already diagnosed with, and showing symptoms of, Parksinon's.
Symptoms of  Parkinson's disease arise with the marked loss of dopamine-producing cells in a brain region called the substantia nigra. Previous studies...

Caffeine Has an Intriguing Effect on The Brains of Parkinson's Patients

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

UPI News

Caffeine has been associated with a reduced risk of developing Parkinson's disease, but a new study says a coffee jolt might not be good for people already diagnosed with the brain disorder.

Drinking coffee may affect dopamine function in patients with Parkinson's

Medical News Today

A new study demonstrates that depression may worsen memory decline, but one condition may also exacerbate the other. Experts note the pathology of depression and memory loss overlap within the brain.

How depression may worsen memory decline in older adults

Summary: Researchers developed a novel peptide, KS-133, to target cognitive dysfunction in schizophrenia. By using a brain-targeting peptide, KS-487, they successfully transported KS-133 across the blood-brain barrier. Their nanoparticle-based drug delivery system improved cognitive functions in mice, offering a new therapeutic strategy. Key Facts:. KS-133 targets the VIPR2 gene linked...

Peptide Improves Cognition in Schizophrenia

Health

Medically reviewed by Doru Paul, MDMedically reviewed by Doru Paul, MDGlioblastoma (GBM), also called glioblastoma multiforme, is an aggressive type of brain cancer. While the cancer does not usually spread to other parts of the body, it can quickly spread to other areas of the brain. As the tumor puts pressure on the brain, you can develop a variety of symptoms.Some glioblastoma symptoms, like headache and nausea, are common in all types of brain cancers. These symptoms are known as generalized symptoms. Other symptoms—and how severe they are—can depend on where the tumor is and how big it is. These...

Signs and Symptoms of Glioblastoma (GBM)

Irish Star

People with one key family member who were diagnosed with Alzheimer's at 65 or younger were also found to have higher-than-average amyloid levels in their brains, a new study has found

Alzheimer's risk is 'higher' if key member of your family has it

Researchers have successfully reversed the symptoms of Alzheimer’s disease in mice with a small, synthetic peptide called PHDP5.

Peptide treatment could reverse cognitive decline in Alzheimer's disease

Medically reviewed by Smita Patel, DOMedically reviewed by Smita Patel, DOPOEMS syndrome is a very rare multisystem condition where the body's immune system attacks cells in the nervous system. This attack from the immune system is caused by an abnormal immune response to a cancerous tumor.POEMS syndrome symptoms include weakness of the arms and legs, darkening of the skin, and an abnormal increase in the size of lymph nodes and internal organs like the spleen or liver.POEMS syndrome is a chronic (long-term) disorder with no cure. In the United States, POEMS syndrome affects approximately 5,000 people. The disease occurs 1.5...

POEMS Syndrome

A new study reveals a link between gut microbiota and Parkinson's disease, finding that people may have fewer bacteria that produce riboflavin (vitamin B2) and biotin (vitamin B7).

Study suggests 2 vitamin B deficiencies may play a role in Parkinson's disease

Alzheimer's research may have found a way patients can protect their memory just by inhaling menthol, according to a new study. Alzheimer's disease is a neurodegenerative disease, meaning it worsens over time. Brain changes occur as neurons and connections die. Scientists at Edinburgh Napier University found that when mice with Alzheimer's inhaled menthol, their cognitive ability improved. The experiment, conducted over six months, involved repeatedly exposing mice with Alzheimer's to menthol. Researchers found that it lowered levels of interleukin-1 beta, a protein linked to cognitive decline in Alzheimer's. Menthol was also seen to mimic reducing T-regulatory cells, immune cells that control inflammation and balance the immune system. These new findings suggest a possible treatment for conditions like Alzheimer's.

Menthol May Be Key To Protecting Memory Loss From Alzheimer's

Menthol, an extract from mint herbs, could improve cognition, including memory and learning capabilities, a groundbreaking new study revealed — a huge advancement in Alzheimer's research

Menthol can improve worst symptoms of Alzheimer's, new study finds

“Neurological disabilities” is an umbrella term to describe a wide range of nervous system disorders. Disorders can occur before birth or after as a result of various factors including head trauma, infections, nutrient deprivation, or others. The World Health Organization (WHO) has stated that 1 in 3 people worldwide are affected by neurological disorders. Some of these disorders include epilepsy, learning disabilities, neuromuscular disorders, autism, and over 600 more, according to the U.S. National Library of Medicine. In many neurological disorders neurons die or become dysfunctional, which causes poor communication between the muscles and nervous system. As a result, muscle atrophy can occur and cause further health complications. Scientists within the field are working to understand these neurological disorders more and identify solutions for nerve damage. In an exciting breakthrough, one research group at The Ohio State University has discovered an immune cell that can regenerate nerve fibers.

Novel Treatment Regenerates Nerve Fibers in Neurological Disorders

(CN) — Researchers with the American Society for Microbiology think that there may be a link between a chemical metabolized by the bacteria in the digestive system, known as DHPS, and three neurodegenerative diseases. Presented at ASM Microbe, the society's annual meeting, on Sunday, the research is one of...

Sulfur-based metabolites consumed by gut bacteria could be linked to neurodegenerative diseases

NewsBreak

Serotonin 2C Receptor Key to Memory

Summary: Researchers discovered the serotonin 2C receptor in the brain plays a crucial role in regulating memory in both humans and animal models. This breakthrough offers...

Serotonin 2C Receptor Key to Memory

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