Columbus, OH

ScienceAlert


Diagnosing dementia early gives us more time to put precautions in place and to study exactly how the condition progresses – and a new method for predicting conditions such as  Alzheimer's disease is promising up to nine years of advance warning.



					
			

The method, developed by a team from the Queen Mary University of London in the UK and Monash University in Australia, involves a neurobiological model that analyzes brain scans captured by functional magnetic resonance imaging, or fMRI.
In tests, the model was more than 80 percent accurate at predicting the development of dementia. That has huge potential in terms of...

Dementia Breakthrough: Brain Scans Predict Disease Up to 9 Years Early


Researchers have discovered how a cell surface protein called Aplp1 can play a role in spreading material responsible for  Parkinson's disease from cell-to-cell in the brain.
Promisingly, an FDA-approved  cancer drug that targets another protein called Lag3 – which interacts with Aplp1 – blocks the spread in mice, suggesting a potential therapy may already exist.



					
			

In a new paper, an international team of scientists describes how the two proteins work together to help harmful alpha-synuclein protein clumps get into brain cells.
"Now that we know how Aplp1 and Lag3 interact, we have a new way of understanding how alpha-synuclein contributes to...

Parkinson's Discovery Suggests We May Already Have an FDA-Approved Treatment

MRI shows that women who have their ovaries removed before menopause have reduced white matter integrity in multiple regions of the brain later in life, according to research published June 20 in Alzheimer’s & Dementia. A team led by Michelle Mielke, PhD, from Wake Forest University in Winston-Salem, NC,...

MRI shows ties between ovary removal and brain function later in life

Article written by Emily Spencer, Edinburgh Napier University. Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. This might sound like science fiction, but innovative new research is making it a potential reality. Scientists have discovered that when mice with...

Alzheimer’s patients could protect memory simply by inhaling menthol, mouse study shows

San Diego, CA

Researchers at the University of California San Diego discovered that an unusually large brain could be the first sign of autism, potentially detectable in as early as the first trimester. Some children with autism face severe, enduring challenges including developmental delays, social difficulties, and possibly an inability to speak. Meanwhile,...

Scientists May Have Discovered the First Sign of Autism: An Unusually Large Brain

CBS Miami

A brain aneurysm is a potentially life-threatening condition characterized by a weakened or ballooning blood vessel in the brain. While many people may live with an unruptured brain aneurysm without experiencing any symptoms, a ruptured aneurysm can lead to a sudden and severe headache, often described as the worst headache of one's life. Understanding the types, symptoms, risk factors, and when to seek care is crucial for prompt diagnosis and treatment.Symptoms and Risk Factors: Unruptured brain aneurysms smaller than 5-6 millimeters often do not cause symptoms and are discovered incidentally during imaging tests for other conditions. However, when an aneurysm...

Understanding Brain Aneurysms: Symptoms and Advanced Treatment Options

Changes in how regions of the brain interact with each other, which occur during the surgical procedure for deep brain stimulation (DBS), can temporarily ease motor symptoms of Parkinson’s disease, even before the electrical stimulation is turned on, a study finds. The microlesion effect, as this temporary improvement is...

Brain rewiring eases Parkinson’s symptoms before DBS is turned on

Montana State

The newly discovered Lokiceratops rangiformis features distinctive horns and a caribou-like frill, representing a significant addition to the diversity of North American centrosaurine dinosaurs. Unearthed in Montana and now housed in Denmark, this species offers a glimpse into the rich ecological dynamics of Cretaceous North America. What do you get...

Meet Lokiceratops: New Dinosaur Wields Spectacular Blade-Like Horns

MRI illuminates the structural and functional organization of the brain -- thus helping clinicians predict the progression of Parkinson's disease in patients in its early stages, researchers have found. A team led by Silvia Basaia, PhD, of the IRCCS San Raffaele Scientific Institute in Milan, Italy, reported that Parkinson's "disease...

MRI predicts Parkinson's disease progression

The ovaries are involved in far more than just reproduction. The two oval-shaped glands that float on either side of the uterus don't just produce and release eggs, they also pump out hormones that help keep a person's heart, bones, brain, and immune system healthy as they age. A new...

Losing Both Ovaries Could Come at a Serious Cost to The Brain, Researchers Find

Research teams have successfully regenerated mouse brain circuits using rat stem cells, showcasing a new method for restoring brain function and studying interspecies brain development. These findings open up possibilities for treating neurological diseases and understanding brain evolution, while also hinting at future clinical applications and ethical challenges in using...

Revolutionizing Regeneration: Rat Stem Cells Restore Mouse Brain Circuits

A recent study has unveiled the origins of the mysterious “heartbeats” observed in neutron stars, relating them to glitches caused by the dynamics of superfluid vortices. Researchers found that these glitches follow a power-law distribution similar to other complex systems and developed a model based on quantum vortex networks that aligns with observed data without extra tuning.

Quantum Vortex Mystery: Unveiling the Twisted Roots of Neutron Stars’ Puzzling Pulses

About 170 billion cells are in the brain, and as they go about their regular tasks, they produce waste — a lot of it. To stay healthy, the brain needs to wash away all that debris. But how exactly it does this has remained a mystery. Now, two teams...

The brain makes a lot of waste. Now scientists think they know where it goes

A recent study has revealed significant insights into the early brain changes associated with Alzheimer’s disease, focusing on volume loss in key brain regions. The researchers found that volume loss in the basal forebrain and hippocampus is more pronounced in individuals with high levels of amyloid-beta, a protein linked to Alzheimer’s, even before cognitive symptoms become apparent. The effect of amyloid-beta concentration on the pace of brain shrinkage (volume loss) varied between brain regions. The study was published in the Neurobiology of Aging.

Scientists observe faster brain shrinkage in Alzheimer’s patients with high amyloid-beta levels

Researchers at the University of Rochester, working with the CMS Collaboration at CERN, have made significant advancements in measuring the electroweak mixing angle, enhancing our understanding of the Standard Model of Particle Physics. Their work helps explain the fundamental forces of the universe, supported by experiments like those conducted at...

Milestone Achieved in Unraveling the Universe’s Fundamental Forces at the Large Hadron Collider

Reactivating dormant metabolic pathways in cancer cells can aid in combating cancer. An international team of researchers has developed a novel method for treating cancer by leveraging nutrients to reactivate dormant metabolic pathways in cancer cells. The team utilized a widely available amino acid, tyrosine, delivered in nanomedicine form, to alter the metabolism of melanoma, a severe form of skin cancer, thereby inhibiting cancer growth.

Harnessing Nutrients: Scientists Discover New Way To Effectively Treat Cancer

Medical News Today

Researchers have successfully reversed the symptoms of Alzheimer’s disease in mice with a small, synthetic peptide called PHDP5.

Peptide treatment could reverse cognitive decline in Alzheimer's disease

A crucial protein in early brain development could hold the key to preventing autism and other neurological disorders. Researchers at Cold Spring Harbor Laboratory have identified how this protein shapes sensory circuits in newborn mice, potentially opening new avenues for early intervention in humans. Pruning the Brain’s Connections. As...

Brain Protein Discovery Could Lead to New Autism Treatments

An international research team has estimated that Mars is hit by 280 to 360 large meteorites annually, based on seismic data from NASA’s InSight Mission. This rate is five times higher than estimates derived from orbital images, highlighting the effectiveness of seismology in impact studies. For the first time,...

Mars Quakes Reveal Daily Meteor Bombardments on the Red Planet

Health

Medically reviewed by Smita Patel, DOMedically reviewed by Smita Patel, DOPOEMS syndrome is a very rare multisystem condition where the body's immune system attacks cells in the nervous system. This attack from the immune system is caused by an abnormal immune response to a cancerous tumor.POEMS syndrome symptoms include weakness of the arms and legs, darkening of the skin, and an abnormal increase in the size of lymph nodes and internal organs like the spleen or liver.POEMS syndrome is a chronic (long-term) disorder with no cure. In the United States, POEMS syndrome affects approximately 5,000 people. The disease occurs 1.5...

POEMS Syndrome

NewsBreak

MIT’s Ultrasound Breakthrough: A New Era in Non-Invasive Brain Healing

MIT’s implantable ImPULS device could become an alternative to the electrodes now used to treat Parkinson’s and other diseases. MIT engineers developed a hair-thin ultrasound device...

MIT’s Ultrasound Breakthrough: A New Era in Non-Invasive Brain Healing

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