Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

A new study from Austria has uncovered a direct connection between specific gut bacteria and food addiction in both mice and humans. The research, published in the journal Gut, offers new insights into the complex relationship between gut microbiota and eating disorders. Researchers from an international team, led by Professor...

Gut Bacteria Linked to Food Addiction: New Hope for Obesity Treatment

ScienceAlert

Choose your comfort foods carefully. Stress-eating may initially soothe a worried mind, but according to a new study, certain fatty foods can also fuel more anxiety in the long run. Eating a particular kind of high-fat diet – mainly saturated fats from animal products – disrupted the gut microbiome of...

Eating a High-Fat Diet May Increase Your Anxiety, Study Warns

Medical News Today

Scientists have found that people missing a specific blood group due to a genetic variant may be genetically predisposed to having obesity or overweight.

Missing a specific blood group may genetically predispose people to obesity

(CN) — Researchers with the American Society for Microbiology think that there may be a link between a chemical metabolized by the bacteria in the digestive system, known as DHPS, and three neurodegenerative diseases. Presented at ASM Microbe, the society's annual meeting, on Sunday, the research is one of...

Sulfur-based metabolites consumed by gut bacteria could be linked to neurodegenerative diseases

A major cause of inflammatory bowel disease (IBD) has been discovered by UK scientists. They found a weak spot in our DNA that is present in 95% of people with the disease. It makes it much easier for some immune cells to go haywire and drive excessive inflammation in the bowels.

Major cause of inflammatory bowel disease found

Well+Good

If you've been feeling a rumbling in your stomach every day (promptly followed by loose stools), but don't have any other red flags pointing to things like food poisoning or a bug, you might be wondering what the heck's going on in your gut. Turns out, it is possible to have diarrhea every day without being sick; consistently loose poop doesn't always mean you have a gastrointestinal (GI) infection. Instead, daily diarrhea can signal an underlying health condition that needs to be addressed.

Wait, Why Do I Get Diarrhea Every Day (Even When I’m Not Sick)?

Seniors Guide

The post What Causes Irritable Bowel Syndrome? appeared first on Seniors Guide.

What Causes Irritable Bowel Syndrome?

The spice turmeric is a popular food supplement due to a molecule it contains called curcumin, which acts as a strong antioxidant. it is also thought that it could be used to treat or prevent inflammatory conditions. Turmeric’s use has grown in popularity in the past decade or two, with...

Turmeric and black pepper supplements linked to liver injury in some people

Vitamin B12 deficiency is common. It can lead to various health issues, affecting everything from energy levels to brain function. Vitamin B12, or cobalamin, is an essential nutrient in meat, fish, and dairy products. It is crucial for red blood cell production and a healthy nervous system. When B12 levels...

Unusual symptoms of B12 deficiency

Understanding your bowel movements is crucial for maintaining overall health. Your colon, also known as the large intestine, plays a significant role in your digestive system. Constipation and other changes in bowel movements can be indicators of your colon’s health. In this article, we’ll explore what these signs mean and how you can maintain a healthy colon.

What constipation and bowel movements tell you about your colon

If you experience digestive or full-body symptoms after eating bread, pasta, or desserts, you may have one of a few gluten-related disorders—two of which are gluten intolerance and celiac disease. The conditions can cause similar symptoms, and the terms are often used interchangeably, but they are not the same. So, how do you know which one you may have?

Gluten Intolerance vs. Celiac Disease: How to Tell the Difference

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Total Apex Sports & Entertainment

There are certain zodiac signs that most people are careful with because of their fiery and low tolerance levels. You can hardly mess with individuals with such signs without getting a backlash. Whether they are in work environments or family settings, they do not hesitate to set boundaries and protect them.

5 Zodiac Signs You Don't Mess With

A recent preclinical study found that supplementation with a branded pomegranate extract called Pomanox, from Euromed, may support liver health and alleviate fructose-induced metabolic impairment. A recent preclinical study1 found that supplementation with a branded pomegranate extract (Pomanox from Euromed based in Mollet del Vallès, Spain) may support liver health...

Animal study finds that branded pomegranate extract may alleviate the impacts of fructose consumption on liver metabolism

Woman's World

Turns out menopause can increase your odds of dehydration

Experts Reveal the Sneaky Symptoms of Dehydration You Might Be Missing + How to up Your Water Intake

shefinds

As we age, maintaining a healthy diet becomes increasingly crucial—especially when menopause comes into play. A balanced diet can help manage weight, reduce the risk of chronic diseases, and improve overall well-being. Particularly during menopause, ...

Nutritionist Warns Against 3 Inflammatory Foods To Avoid If You're Going Through Menopause: Vegetable Oils & More

Peru, IN

Logansport, IN

Kristy Tallman

Logansport, Ind. – The Indiana State Police (ISP) are seeking the public's assistance in locating 14-year-old Bryson Muir, who is believed to be missing and endangered. Investigators from ISP have recently communicated with Bryson's parents, Daniel and Kristen Muir. Despite their initial lack of cooperation, they have begun to show signs of willingness to assist in the investigation. However, Bryson has yet to be seen or located by ISP or the Cass County Department of Child Services (DCS).

UPDATE: Urgent Search Intensifies for Endangered 14-Year-Old Bryson Muir!

Anxiety doesn’t directly cause IBS, but it may make your symptoms worse. Overlapping genetic pathways and two-way communication between your gut and your brain could help explain the link between these two conditions. It’s fairly common to notice gastrointestinal (GI) symptoms when you’re feeling anxious. Known as having a...

Your Guide to Navigating Anxiety and Irritable Bowel Syndrome

Los Angeles, CA

A Los Angeles man was overwhelmed with emotion after hearing voices clearly for the first time, thanks to a cochlear implant. Aric Hoffmann has lived with hearing impairment since he was a boy, after contracting meningitis when he was just six months old. Up until now, the 28-year-old had to...

28-Year-old Man is Overwhelmed With Emotion After Hearing for the First Time–Watch

Irritable bowel syndrome (IBS) causes chronic gut discomfort; it's characterized by abdominal pain, bloating, gas, distension, and bowel problems like diarrhea and constipation. It's estimated that as many as one in seven people may have IBS, which can lead to serious disruptions in quality of life. Now, scientists have determined that a diet could help as many as seven of every ten IBS patients find relief. The FODMAP diet significantly reduced patients' symptoms in a trial. The findings were reported in The Lancet Gastroenterology & Hepatology.

For Treating IBS, the FODMAP Diet is Better Than Medications

NewsBreak

Specific Gut Bacteria That Triggers Compulsive Eating Identified by Scientists Who Also Found Bacteria to Prevent it

Compulsive eating and obesity may be triggered by a specific gut bacteria, suggests a new study—and the breakthrough may lead to new treatments to address the...

Specific Gut Bacteria That Triggers Compulsive Eating Identified by Scientists Who Also Found Bacteria to Prevent it

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