Teva Pharmaceuticals is launching the first-ever generic GLP-1 drug in the United States. Victoza, originally approved by the FDA in 2010 for diabetes, is part of the same class of drugs that includes Ozempic, Wegovy, and Zepbound. Experts say they welcome the generic formulation but expressed concerns about price and...

Victoza: Generic GLP-1 Drug Similar to Ozempic Now Available

Reuters

(Reuters) -U.S. President Joe Biden and Senator Bernie Sanders called on Novo Nordisk and Eli Lilly to reduce the prices of their weight-loss and diabetes drugs, in a jointly authored opinion piece published in USA Today on Tuesday.

Novo Nordisk, Lilly must cut US prices of weight-loss drugs, Biden says

Teva Pharmaceuticals launched the first generic GLP-1 receptor agonist, liraglutide 1.8 mg, for patients aged 10 years or older with type 2 diabetes. “By launching an authorized generic for Victoza (liraglutide injection 1.8 mg), we are providing patients with type 2 diabetes another option for this important treatment,” Ernie Richardsen, senior vice president and head of U.S. commercial generics at Teva, said in a press release. “In addition to strengthening Teva’s diverse complex generics portfolio, we are providing the first generic GLP-1 product to the U.S. marketplace, demonstrating once again our ability to sustain a generics powerhouse.”

Top in endocrinology: First generic GLP-1; semaglutide offers benefits regardless of HbA1c

Metformin, a medication commonly used to treat type 2 diabetes, helps the body regulate sugar in the bloodstream. Part of the class of drugs known as biguanides, metformin reduces the amount of sugar you absorb from food and the amount produced by the liver. Metformin also impacts the way the body will respond to insulin, the natural substance that regulates blood sugar levels.

Diabetes Drug Metformin Investigated for Cancer Prevention Use

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

NovoLog (insulin aspart) is a prescription injection used to manage blood sugar levels in adults and children with diabetes. NovoLog can interact with alcohol, supplements, and other medications such as diabetes drugs and beta-blockers. Before you start using NovoLog, tell your doctor and pharmacist about any prescription, over-the-counter, or other...

NovoLog Interactions: Alcohol, Medications, and Others

Eli Lilly said it applied for U.S. approval of its weight loss drug Zepbound for the treatment of the most common sleep-related breathing disorder and expects regulators to make a decision as early as the end of the year. The company released additional data from two late-stage trials showing that...

Eli Lilly expects FDA decision on weight loss drug Zepbound for sleep apnea as early as end of the year

Newark, NJ

Contributors represent independent, third-party users who have joined our contributor program and self-verified their accounts. They have also demonstrated their experience writing hard news for other outlets. Contributors are expected, like all users, to adhere to our Community Standards.

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Morristown Minute

NEWARK, N.J. – Eight individuals associated with the "793 Bloods" street gang, a subset of the national Bloods gang, have been charged for their roles in a Newark-based drug trafficking organization, U.S. Attorney Philip R. Sellinger announced.

Eight '793 Bloods' Gang Members Charged in Newark Drug Network

GLP-1 medications like semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and tirzepatide (Mounjaro, Zepbound) are making headlines in type 2 diabetes, but people with type 1 diabetes (T1D) are taking these medications, too. No, these medications are not approved by the U.S. Food and Drug Administration (FDA) for T1D, but nonetheless many people are taking them off-label with the full approval of their doctors.

Why We Take Ozempic for Type 1 Diabetes

This content originally appeared on Everyday Health. Republished with permission. Semaglutide significantly lowered the rate of complications in individuals with diabetes and chronic kidney disease. People on semaglutide saw an 18 percent drop in their risk of cardiovascular complications like heart attack and a 20 percent drop in the risk...

Ozempic and Wegovy Slash Kidney Disease Risks in People With Diabetes

Burlington County, NJ

Pablo Estrada, 27, laundered proceeds from a mail fraud scheme, including lottery scams. Florence, NJ – Pablo Estrada, 27, of Burlington County, was sentenced to 33 months in prison for his role in laundering over $4 million obtained from various scams. U.S. Attorney Philip R. Sellinger announced the sentencing today.

Burlington Man's $4M Money Laundering Scheme: 33-Month Sentence

Eli Lilly received FDA approval for a drug to help treat Alzheimer's on Tuesday after studies showed it could help slow the progress of the disease. The treatment, which is called donanemab and will be sold under the brand name Kisunla, is a monthly IV infusion. The drug, which faced...

FDA Approves Eli Lilly's Alzheimer's Drug Kisunla

ScienceAlert


Researchers have discovered how a cell surface protein called Aplp1 can play a role in spreading material responsible for  Parkinson's disease from cell-to-cell in the brain.
Promisingly, an FDA-approved  cancer drug that targets another protein called Lag3 – which interacts with Aplp1 – blocks the spread in mice, suggesting a potential therapy may already exist.



					
			

In a new paper, an international team of scientists describes how the two proteins work together to help harmful alpha-synuclein protein clumps get into brain cells.
"Now that we know how Aplp1 and Lag3 interact, we have a new way of understanding how alpha-synuclein contributes to...

Parkinson's Discovery Suggests We May Already Have an FDA-Approved Treatment

Kentucky State

Northern Kentucky Tribune

Kentucky’s medical cannabis program has taken significant steps toward ensuring those with qualifying conditions have access to medical cannabis as soon as possible, said Gov. Andy Beshear this week.

State to open licensing applications for medical cannabis businesses beginning July 1

Missouri State

Writers represent independent, third-party users who have joined our contributor program and self-verified their accounts. Writers are expected, like all users, to adhere to our Community Standards.

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CJ Coombs

According to Shakey's website, this pizza parlor is only in California, North Carolina, and Washington state in the U.S. now. This was my family's go-to pizza joint when my father was stationed with the Air Force outside of Omaha, Nebraska. We liked it so much, that when we were transferred again, it was hopeful we'd find another one.

Shakey's Pizza Parlor and nostalgia: the first franchised pizza restaurant also landed in Missouri

Georgia State

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Coffee County, GA

Douglas, GA

Daily Coffee Press

A 49-year-old woman from Douglas was recently arrested for allegedly submitting a life insurance policy for her ex-husband without his knowledge. According to a Coffee County Sheriff’s Office incident report, detectives met with a man on May 7 at the Coffee County Law Enforcement Center concerning a reported case of insurance fraud.

Georgia woman charged for allegedly filing life insurance policy application on ex-husband

California State

Alameda Post

California regulators just stopped AT&T from pulling the plug. California’s Public Utilities Commission on June 20 rejected AT&T’s application to stop providing landlines and other services in areas where there is no other option.

Still Need Your Landline?

Eli Lilly has finally achieved FDA approval for its monoclonal antibody Alzheimer’s therapy donanemab, bringing new competition to the field for Eisai and Biogen. Donanemab, which will be known as Kisunla, has been given full approval by the US Food and Drug Administration (FDA) for treatment of early, symptomatic Alzheimer’s disease.

FDA approves Kisunla for early Alzheimer's treatment amid cognitive decline slowdown

TARRYTOWN, N.Y. — The European Medicines Agency (EMA) has approved Dupixent (dupilumab) as an add-on maintenance treatment for adults with uncontrolled chronic obstructive pulmonary disease (COPD) characterized by raised blood eosinophils. Specifically, the approval covers patients already on a combination of an inhaled corticosteroid (ICS), a long-acting beta2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA), or on a combination of a LABA and a LAMA if ICS is not appropriate. The EMA is the first regulatory authority in the world to approve Dupixent for COPD patients. Additional submissions are under review with other regulatory authorities around the world, including in the US, China, and Japan.

Regeneron, Sanofi: EU approves Dupixent as first-ever targeted therapy for COPD patients

Bucks County Beacon

If you hadn’t read the news in four years — or just arrived from another galaxy — the Supreme Court’s de facto grant of immunity to Donald Trump for his alleged federal crimes might sound almost reasonable.

The Supreme Court’s Immunity Ruling Gives Trump King George III’s Power

NewsBreak

Generic Victoza Now Available in the U.S.

This content originally appeared on diaTribe. Republished with permission. The launch of generic Victoza comes amid shortages for many different GLP-1 and incretin medications for type...

Generic Victoza Now Available in the U.S.

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