Columbus, OH

Our May 2024 month-in-review for hematology focuses on the latest updates to the hematologic pipeline. With a range of crucial updates across disease spaces, including sickle cell disease (SCD), thalassemia, and other bleeding disorders, our June 2024 month-in-review for hematology focused on the latest updates to the hematologic pipeline. Pipeline...

Hematology Month in Review: June 2024

A high-risk cohort of beneficiaries with chronic kidney disease (CKD) stage 3 have a profile similar to patients with CKD stages 4 and 5, indicating potential benefit of earlier nephrology intervention. ABSTRACT. Objectives: Chronic kidney disease (CKD) is a widely prevalent disease with heterogeneous disease progression. Prior study findings suggest...

Identifying Chronic Kidney Disease Stage 3 With Excess Disease Burden

Metformin, a medication commonly used to treat type 2 diabetes, helps the body regulate sugar in the bloodstream. Part of the class of drugs known as biguanides, metformin reduces the amount of sugar you absorb from food and the amount produced by the liver. Metformin also impacts the way the body will respond to insulin, the natural substance that regulates blood sugar levels.

Diabetes Drug Metformin Investigated for Cancer Prevention Use

Sleeping on the left side may worsen atrial fibrillation (AFib) symptoms for some people, but more research is necessary. The best sleeping position may depend on a person’s symptoms and individual health factors. The connection between sleeping position and AFib symptoms may come down to how different positions can...

What is the best sleep position for atrial fibrillation?

Kidney disease and hypertension therapy late-stage failure will cost the Danish big pharma more than US $800 million. Novo Nordisk announced this week that its phase 3 trial of ocedurenone​ for treatment of high blood pressure in chronic kidney disease has failed. The trial failure is a significant loss...

Blow for Novo Nordisk with phase 3 kidney disease drug failure

A new study recently published in Menopause, the journal of The Menopause Society, suggests a significant link between chronic kidney disease (CKD) and tooth loss, particularly in postmenopausal women. While it is known that kidneys play a vital role in our overall health, serious health conditions can arise when this...

Chronic kidney disease linked to tooth loss in postmenopausal women

Vitamin D could be beneficial as part of the therapeutic scheme for patients with myasthenia gravis (MG), according to a study recently published in BMC Neurology. “While this article constitutes a single case report and thus cannot furnish conclusive evidence for clinical practice, it suggests that physicians should consider monitoring and supplementing vitamin D levels in patients exhibiting MG symptoms following gastrointestinal surgery,” the authors wrote.

Vitamin D Supplementation Shows Promise in Treating MG

Persistently elevated matrix metalloproteinase 2 of increased risk of CKD progression. wmodified by inflammation and proteinuria. Matrix metalloproteinase 2 may be associated with the progression of chronic kidney disease, especially in patients with low inflammation or with proteinuria, data show. “Matrix metalloproteinase 2 (MMP-2), or gelatinase A, is a zinc-containing,...

Matrix metalloproteinase 2 may be associated with CKD progression

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NewSantaAna

The FBI has seen a rise in scams targeting timeshare owners. In this kind of scam, criminals con these part-time property owners into shelling out hefty sums of cash, all under false pretenses related to their timeshare properties.

FBI warns that Mexican cartels are targeting Americans with timeshare scams

Reuters

(Reuters) - Eli Lilly on Friday said its popular weight-loss drug Zepbound helped resolve moderate to severe obstructive sleep apnea in up to 52% of patients in two late-stage trials.

Weight-loss drug Zepbound resolves sleep apnea in up to 52% of patients, Lilly says

Newark, NJ

Morristown Minute

NEWARK, N.J. – Eight individuals associated with the "793 Bloods" street gang, a subset of the national Bloods gang, have been charged for their roles in a Newark-based drug trafficking organization, U.S. Attorney Philip R. Sellinger announced.

Eight '793 Bloods' Gang Members Charged in Newark Drug Network

Throughout June, the FDA approved drugs for the treatment of diseases including myelodysplastic syndrome, thyroid cancer, endometrial cancer, colorectal cancer, and follicular lymphoma. Throughout the month of June, several cancer therapies have received FDA approval for diseases including thyroid cancer, myelodysplastic syndrome (MDS), colorectal cancer (CRC), endometrial cancer, and follicular...

Oncology Drugs Approved by the FDA in June 2024

IRONMAN trial highlighted that anemia severity and TSAT < 20% are key indicators for identifying patients with heart failure who may benefit from intravenous iron therapy. The IRONMAN trial aimed to clarify the relationship between iron deficiency, as indicated by various blood tests, and the response to intravenous iron therapy in patients with heart failure, according to research presented in the European Heart Journal. Conducted on 1,137 patients with heart failure and reduced ejection fraction (≤45%), the study investigated the impact of baseline anemia severity, serum ferritin, and transferrin saturation (TSAT) on the response to intravenous ferric derisomaltose (FDI) compared to usual care.

IV Iron Therapy Benefits Patients With Heart Failure, Severe Anemia, and Low TSAT

Fibromyalgia and sleep apnea both disrupt nighttime sleep. Chronic pain from fibromyalgia can affect your ability to fall or stay asleep. Sleep apnea can increase symptoms of fibromyalgia. Are you finding yourself waking up frequently in the night and having a hard time getting up in the morning? Is fatigue...

The Link Between Fibromyalgia and Sleep Apnea

Hypertension (high blood pressure) is divided into stages based on the severity of the condition. These stages include elevated, stage 1, stage 2, and hypertensive crisis. Doctors stage hypertension based on the severity of the reading. Healthcare professionals test blood pressure as part of routine care. People can also monitor...

What are the stages of hypertension?

Ali Carney, 46, of Newark, received a 65-month prison sentence for conspiring to distribute narcotics, including fentanyl and heroin, and possessing with intent to distribute fentanyl, according to U.S. Attorney Philip R. Sellinger.

Gang Member Sentenced to 65 Months for Drug Trafficking

Metabolic dysfunction-associated steatotic liver disease (MASLD)—the new name for non-alcoholic fatty liver disease (NAFLD)—and its more severe form, metabolic dysfunction-associated steatohepatitis (MASH), are responsible for a growing share of advanced liver disease. Linked to obesity and diabetes, fatty liver disease is increasingly recognized as a metabolic condition. Over...

Treatment for Fatty Liver Disease

It is well known that patients with diabetes are at increased risk for cardiac events, but I am unclear as to what warrants a workup for cardiac disease in this population (e.g., a cardiac stress test) except in instances where patients report such symptoms as angina or dyspnea. Given that...

Cardiac workup for patients  with diabetes 

Approval of Skyrizi marks the first IL-23 specific inhibitor approved for both ulcerative colitis and Crohn disease of similar severity, according to AbbVie. The FDA has approved AbbVie’s Skyrizi (risankizumab-rzaa) for the treatment for adults with moderately to severely active ulcerative colitis (UC). According to the company, this approval makes Skyrizi the first IL-23 specific inhibitor to be approved for both UC and Crohn disease classified as moderate-to-severe. The approval was based on results from the INSPIRE Induction study and the COMMAND Maintenance study. In addition to the approved indications for UC and Crohn disease, Skyrizi also has been approved for active psoriatic arthritis and plaque psoriasis.1.

FDA Approves AbbVie’s Skyrizi for the Treatment of Adults with Moderate to Severely Active Ulcerative Colitis

Healthline

IBD and endometriosis can result in similar symptoms, such as severe abdominal pain. However, further research is still needed to confirm a link.

IBD and Endometriosis: Is There a Link?

NewsBreak

Nephrology Month in Review: June 2024

This June 2024 month in review spotlights HCPLive’s coverage of the latest renal news and research in IgA nephropathy, differences in care, and novel associations in...

Nephrology Month in Review: June 2024

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