Columbus, OH

Many adults with spinal muscular atrophy (SMA) have metabolic syndrome, and those who do tend to report worse life quality and fatigue, according to a study from Germany. Nine of 36 SMA adults enrolled in the study — exactly one-quarter — met the diagnostic criteria for metabolic syndrome, or MetS, according to the study, “Metabolic syndrome is common in adults with 5q-spinal muscular atrophy and impacts quality of life and fatigue,” published in Muscle and Nerve.

25% of adults with SMA in German study had metabolic syndrome

Diabetes, or diabetes mellitus, is to a group of chronic conditions that affect your glucose (blood sugar) levels due to problems with the way your body produces or uses the hormone insulin. In rare cases, diabetes can lead to the complication bullosis diabeticorum, also known as diabetic blisters or diabetes bullae.

Diabetic Blisters: A Symptom of Mismanaged Diabetes?

(HealthDay News) — Glucose lowering by metformin is greater when given before enteral glucose among patients with type 2 diabetes controlled by metformin monotherapy, according to a study recently published in Diabetologia. Cong Xie, PhD, from the University of Adelaide in Australia, and colleagues studied 16 participants with type...

Timing of metformin important in metformin-treated type 2 diabetes

Healthline

IBD and endometriosis can result in similar symptoms, such as severe abdominal pain. However, further research is still needed to confirm a link.

IBD and Endometriosis: Is There a Link?

Vitamin D could be beneficial as part of the therapeutic scheme for patients with myasthenia gravis (MG), according to a study recently published in BMC Neurology. “While this article constitutes a single case report and thus cannot furnish conclusive evidence for clinical practice, it suggests that physicians should consider monitoring and supplementing vitamin D levels in patients exhibiting MG symptoms following gastrointestinal surgery,” the authors wrote.

Vitamin D Supplementation Shows Promise in Treating MG

Approval of Skyrizi marks the first IL-23 specific inhibitor approved for both ulcerative colitis and Crohn disease of similar severity, according to AbbVie. The FDA has approved AbbVie’s Skyrizi (risankizumab-rzaa) for the treatment for adults with moderately to severely active ulcerative colitis (UC). According to the company, this approval makes Skyrizi the first IL-23 specific inhibitor to be approved for both UC and Crohn disease classified as moderate-to-severe. The approval was based on results from the INSPIRE Induction study and the COMMAND Maintenance study. In addition to the approved indications for UC and Crohn disease, Skyrizi also has been approved for active psoriatic arthritis and plaque psoriasis.1.

FDA Approves AbbVie’s Skyrizi for the Treatment of Adults with Moderate to Severely Active Ulcerative Colitis

Atherosclerotic cardiovascular disease is linked to plaque buildup in blood vessels. It can increase the risk of serious cardiovascular events, such heart attack and stroke. Statins are a medication type that can help people at risk for atherosclerotic cardiovascular disease. Doctors look at several factors to determine if statin therapy makes the most sense for someone.

17 million US adults may no longer receive statin therapy for heart disease

The following is a summary of “Plasma Proteins associated with Chronic Histopathologic Lesions on Kidney Biopsy,” published in the April 2024 issue of Nephrology by Kim et al. Chronic kidney disease (CKD) worsens with severe kidney biopsy findings as the severity of chronic histopathologic lesions is independently associated...

Understanding Correlation Between Kidney Damage and Plasma Proteins

It is well known that patients with diabetes are at increased risk for cardiac events, but I am unclear as to what warrants a workup for cardiac disease in this population (e.g., a cardiac stress test) except in instances where patients report such symptoms as angina or dyspnea. Given that...

Cardiac workup for patients  with diabetes 

Vitamin B12 deficiency is common. It can lead to various health issues, affecting everything from energy levels to brain function. Vitamin B12, or cobalamin, is an essential nutrient in meat, fish, and dairy products. It is crucial for red blood cell production and a healthy nervous system. When B12 levels...

Unusual symptoms of B12 deficiency

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Emily Standley Allard

If you know someone born under the zodiac sign of Cancer, you've probably felt the intensity of their emotions. When a Cancer gets emotional, they can turn a light shower into a monsoon or a friendly hug into a lifetime commitment! Cancer, the fourth sign of the zodiac, spans from June 21 to July 22. Represented by the Crab, Cancer is a Water sign, deeply connected to emotions, intuition, and the subconscious. Governed by the Moon, which represents emotions, Cancer is known for its profound sensitivity, nurturing nature, and emotional depth. Let's delve into the complexities of Cancer and explore why they are considered one of the most emotional and sensitive signs of the zodiac.

The Most Sensitive and Emotional Zodiac Sign

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

Total Apex Sports & Entertainment

Do you find it difficult to find what you are looking for? Is it difficult to find ways to organize your house, your office, and your life? Who are those managers of organization? I know I see them all of the time, I'm sure you do too. Those people who seem to always have it all together. Those people with planners, calendars, organized shelves and closets, nice neat cars. Who are they? Let's find out.

Top 3 Most Organized Zodiac Signs

Our May 2024 month-in-review for hematology focuses on the latest updates to the hematologic pipeline. With a range of crucial updates across disease spaces, including sickle cell disease (SCD), thalassemia, and other bleeding disorders, our June 2024 month-in-review for hematology focused on the latest updates to the hematologic pipeline. Pipeline...

Hematology Month in Review: June 2024

People have different levels of maturity. An individual’s age or upbringing can make them possess certain traits. Yet, most people believe that one matures as they grow old. On the contrary, some zodiac signs appear childish in old age. They are jumpy and careless. This strains their relationships with signs who misunderstand them. Air and fire signs are temperamental and some people refer to them as being childish. How can you identify an immature sign?

3 Zodiac Signs Who Are Immature

Just like all zodiac signs have their sweet and toxic personality traits, certain signs have criminal tendencies. Some signs are known for their passion and unpredictable nature, while others are known for their intense emotions, aggression, and unforgiveness. Such traits could transform into criminality or influence individuals to commit one crime or the other.

3 Zodiac Signs With Criminal Tendencies

Some zodiac signs are a little more expressive with their anger (we see you, Aries), and some are more likely to push their feelings down. Let's talk about the three signs that are more likely to repress their anger within and what that looks like for each individual zodiac sign.

3 Zodiac Signs That Stifle Their Anger

HCPLive spoke with Joshua M. Cohen, MD, MPH, to discuss a post-hoc analysis of a phase 3 study that showed buprenorphine may be effective at reducing fentanyl use. A post hoc analysis suggests buprenorphine (Brixadi) may be effective for treating opioid use disorder (OUD) with fentanyl use and extended-release subcutaneous injected formulation may help in reducing fentanyl use.1.

Extended-Release Subcutaneous Buprenorphine Injection May Reduce Fentanyl Use

Medical News Today

New research argues that the oral alternative to injected semaglutide could also help improve the symptoms of diabetes and cardiovascular diseases.

Is oral semaglutide a promising alternative in treating diabetes, heart disease?

Upadacitinib is associated with significant improvements in health-related quality of life (HRQoL) outcomes relative to placebo among patients with Crohn disease (CD), according to study findings from a pooled analysis of clinical trial data published in the Journal of Crohn’s and Colitis. Patients with CD report poor HRQoL, including...

Upadacitinib in Crohn Disease Improves HRQoL Outcomes as Early as 4 Weeks

NewsBreak

Metabolic Syndrome Linked to Renal, Cardiovascular Outcomes in IgA Nephropathy

Findings highlight the prognostic value of metabolic syndrome components in predicting both renal and cardiovascular outcomes in patients with IgA nephropathy. Findings from a recent study...

Metabolic Syndrome Linked to Renal, Cardiovascular Outcomes in IgA Nephropathy

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