LiveScience

A new study in mice and human cells suggests that a small molecule can help reverse signs of aging by extending telomeres and modulating key genes.

Single molecule reverses signs of aging in muscles and brains, mouse study reveals

DZNE - German Center for Neurodegenerative Diseases. Dexamethasone is one of the most important drugs in the treatment of severe COVID-19, but patients respond very differently to the therapy. Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité – Universitätsmedizin Berlin have now discovered how the cortisone compound influences the impaired inflammatory response and which patients benefit from it. Their method uses so-called single-cell analyses and raises hopes for a precise prediction tool for other therapies and diseases as well. The findings have been published in the scientific journal Cell.

Scientists unravel life-saving effect of dexamethasone in COVID-19

State College, PA

UNIVERSITY PARK, Pa. — Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind. But a team led by Penn State researchers has found a way to reprogram disease evolution and design tumors that are easier to treat.

Re-engineering cancerous tumors to self-destruct and kill drug-resistant cells

New research describes for the first time how a spreading wave of disruption and the flow of fluid in the brain triggers headaches, detailing the connection between the neurological symptoms associated with aura and the migraine that follows. The study also identifies new proteins that could be responsible for headaches and may serve as foundation for new migraine drugs.

Study reveals brain fluid dynamics as key to migraine mysteries, new therapies

San Francisco, CA

Progressive supranuclear palsy (PSP), a mysterious and deadly neurological disorder, usually goes undiagnosed until after a patient dies and an autopsy is performed. But now, UC San Francisco researchers have found a way to identify the condition while patients are still alive. A study appearing in Neurology on July 3...

Scientists may have found how to diagnose elusive neuro disorder

Metformin, a medication commonly used to treat type 2 diabetes, helps the body regulate sugar in the bloodstream. Part of the class of drugs known as biguanides, metformin reduces the amount of sugar you absorb from food and the amount produced by the liver. Metformin also impacts the way the body will respond to insulin, the natural substance that regulates blood sugar levels.

Diabetes Drug Metformin Investigated for Cancer Prevention Use

By analyzing the proteins in the blood, a new blood test and AI tool can identify which at-risk patients are most likely to develop Parkinson's disease.

New blood test could flag Parkinson's disease years before symptoms, study hints

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

(HealthDay News) — Glucose lowering by metformin is greater when given before enteral glucose among patients with type 2 diabetes controlled by metformin monotherapy, according to a study recently published in Diabetologia. Cong Xie, PhD, from the University of Adelaide in Australia, and colleagues studied 16 participants with type...

Timing of metformin important in metformin-treated type 2 diabetes

rolling out

Pancreatic cancer is a daunting diagnosis that affects thousands of people worldwide every year. One of the most challenging aspects of this disease is its subtlety; the symptoms often mimic those of other, less severe conditions. This similarity can lead to delayed diagnosis and treatment, significantly impacting the prognosis. Understanding why pancreatic cancer symptoms resemble other diseases’ symptoms is crucial for early detection and better outcomes. This article will delve into the reasons behind this symptom overlap, explore common symptoms of pancreatic cancer, and provide insights on differentiating these symptoms from other ailments.

Why pancreatic cancer symptoms are similar to other diseases

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Devra Lee

Disclaimer: This content was written by Devra Lee for general informational and entertainment purposes only. This service is to provide astrological information that has been researched, recorded, and observed by the author.

Horoscope for Friday, July 5th

Total Apex Sports & Entertainment

Do you know anyone who has dual nature? Such two-faced zodiac signs are friendly but they gossip about others behind their backs. They can lie to you without batting an eyelid. However, detecting a two-faced person isn’t easy for everyone. They often compliment their friends when they achieve a goal or change their wardrobe. But they will make negative remarks about you to someone else. What other traits do two-faced people have?

3 Zodiac Signs Who Are Two-Faced

Diabetes, or diabetes mellitus, is to a group of chronic conditions that affect your glucose (blood sugar) levels due to problems with the way your body produces or uses the hormone insulin. In rare cases, diabetes can lead to the complication bullosis diabeticorum, also known as diabetic blisters or diabetes bullae.

Diabetic Blisters: A Symptom of Mismanaged Diabetes?

Columbus, OH

“Neurological disabilities” is an umbrella term to describe a wide range of nervous system disorders. Disorders can occur before birth or after as a result of various factors including head trauma, infections, nutrient deprivation, or others. The World Health Organization (WHO) has stated that 1 in 3 people worldwide are affected by neurological disorders. Some of these disorders include epilepsy, learning disabilities, neuromuscular disorders, autism, and over 600 more, according to the U.S. National Library of Medicine. In many neurological disorders neurons die or become dysfunctional, which causes poor communication between the muscles and nervous system. As a result, muscle atrophy can occur and cause further health complications. Scientists within the field are working to understand these neurological disorders more and identify solutions for nerve damage. In an exciting breakthrough, one research group at The Ohio State University has discovered an immune cell that can regenerate nerve fibers.

Novel Treatment Regenerates Nerve Fibers in Neurological Disorders

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	There’s no doubt that women’s healthcare has been seriously understudied and underfunded for far too long. Many of us have heard terms like uterine fibroids and ovarian cysts, but few of us — unless we’ve personally experienced them — know how to identify symptoms or understand treatment options.Cancer Specialist Reveals a Rough Timeline for When Kate Middleton May End Her Preventive Chemotherapy




	When it comes to fibroids, cysts, lumps, and tumors, knowledge is power. When our health is compromised, it’s easy to feel powerless. Knowing when to see a doctor, what questions to ask, and being clear about options is crucial...

How to Tell the Difference Between Cysts, Fibroids, Polyps, & Tumors, According to Doctors

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J. Souza

A fight between passengers marred the final night of a Carnival Cruise Line sailing on June 6th. The incident, which unfolded in the Lido Deck dining room onboard the Carnival Paradise, involved a group of women and resulted in thrown chairs and plates.

Cruise Ship Fight Near Buffet Captured on Camera, Passengers Banned for Life

Metabolic dysfunction-associated steatotic liver disease (MASLD)—the new name for non-alcoholic fatty liver disease (NAFLD)—and its more severe form, metabolic dysfunction-associated steatohepatitis (MASH), are responsible for a growing share of advanced liver disease. Linked to obesity and diabetes, fatty liver disease is increasingly recognized as a metabolic condition. Over...

Treatment for Fatty Liver Disease

A new study has found that patients with transthyretin amyloidosis (ATTR) may have a mixed phenotype including both transthyretin amyloid polyneuropathy (ATTR-PN) and cardiomyopathy (ATTR-CM). In fact, the researchers discovered that polyneuropathy and musculoskeletal symptoms are often present well before a confirmed diagnosis of ATTR-CM. ATTR-PN is a progressive, debilitating...

Polyneuropathy and Musculoskeletal Symptoms May Occur Prior to ATTR-CM

Healthline

Spinal muscular atrophy (SMA) type 0 is a rare genetic disorder that is present before birth and requires immediate care. Learn more.

What is Spinal Muscular Atrophy Type 0?

Pleural mesothelioma is a type of cancer that grows in the tissue that lines the lungs and chest wall. Symptoms can include chest pain, shortness of breath, and a persistent cough. The mesothelium is a single layer of cells that lines the inside of several body cavities, such as the...

Pleural mesothelioma: Symptoms and treatment

NewsBreak

A study led by UPF describes how insulinomas, a rare type of pancreatic beta cell tumor, form

An experimental study led by Pompeu Fabra University describes the mechanism whereby insulinomas, a rare type of neuroendocrine tumour that affects pancreatic beta cells. According to...

A study led by UPF describes how insulinomas, a rare type of pancreatic beta cell tumor, form

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