8 Best Enzyme Cleaners that Get Rid of Pet Odors and Stains

When The Rembrandts sang, “So no one told you life was gonna be this way,” they certainly weren’t referring to being pet parents and struggling to remove those stubborn dog odors and stains in your home, but they could have! Fret not, pet parents of all dog breeds , for the best enzyme cleaners are here to work their magic!

Unlike traditional cleaners that mask odors, enzyme cleaners are biological superstars. They contain live bacteria that break down organic matter — the very stuff causing those doggy smells. Think of them as microscopic ninjas, dissolving the source of the problem and leaving your carpets, furniture, and floors fresh and clean. Sounds promising, eh? Let’s get cleaning!

Are Enzyme Cleaners Worth It?

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How Do Enzyme Cleaners Work?

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Are Enzyme Cleaners Worth It?

While enzyme cleaners might have a slightly higher upfront cost than standard cleaners, the benefits far outweigh the price tag. Here are some of them:

Permanent Odor Removal

Regular cleaners might mask a stain’s scent, but enzymes eliminate it at the source. Those lingering doggy smells won’t stand a chance against these biocatalysts!

Complete Stain Removal

Enzyme cleaners break down the proteins and other organic materials in stains, leaving your carpets and upholstery looking like new. No more faded or discolored areas — just clean, stain-free surfaces.

Safe for Pets and Families

Unlike harsh chemicals, enzyme cleaners are typically safe for pets and children when used as directed. This is very important for creating a safe and healthy environment for everyone in your home.

Long-Term Prevention

By eliminating the source of odors and stains, enzyme cleaners discourage repeat marking. It’s especially helpful for house-training puppies or pets with anxiety-related accidents.

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How Do Enzyme Cleaners Work?

Enzyme cleaners contain specific enzymes designed to break down different types of organic materials. For pet stains, these enzymes target proteins, starches, and other components found in urine, feces, and vomit. Once they reach the stain, they work hard to convert the complex organic molecules into smaller, simpler pieces.

These smaller pieces become a delicious feast for good bacteria, naturally present in your carpets and upholstery. The good bacteria gobble up the enzyme-digested organic matter, eliminating the source of the stain and odor. With the organic material gone, the stain disappears, and any lingering odors are neutralized. You’re left with a clean, fresh surface, free from the evidence of your pet’s little accident.

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The Best Enzyme Cleaners to Buy in 2024

Dealing with accidents is part and parcel of having pets around the house, but lingering odors and unsightly stains can quickly turn a cuddle session into a crinkle-your-nose situation. With a good enzyme cleaner at your disposal, however, you can look forward to a cleaner, odor-free home.

Best Overall Best Urine Cleaner Best Odor Remover Best Stain Remover Best Eco-friendly Best Scented Best Fast-acting

BEST OVERALL

ROCCO & ROXIE Stain & Odor Eliminator

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BEST URINE CLEANER

Kinzua Environmental Urine B-Gone

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BEST ODOR REMOVER

NATURE’S MIRACLE Stain & Odor Remover

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BEST STAIN REMOVER

Simple Solution Extreme Stain Remover

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BEST ECO-FRIENDLY

Biokleen Bac-Out Carpet Stain + Odor Remover

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BEST SCENTED

ANGRY ORANGE Stain Remover Enzyme Cleaner

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BEST FAST-ACTING

Sunny & Honey Pet Stain & Odor Miracle

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BEST OVERALL

ROCCO & ROXIE Stain & Odor Eliminator

PHOTO CREDIT: ROCCO & ROXIE

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Why We Love

Safe for pets and children

Multi-surface cleaner

Certified gentle and safe for carpets

Eliminates various organic stains

Gentle formula

Neutralizes odors

But…

It is more expensive than other enzyme cleaners on our list

The Rocco & Roxie Stain & Odor Eliminator tackles messes wherever they happen — carpets, floors, furniture, clothing, litter boxes, kennels — you name it! This versatile cleaner is your one-stop shop for a stain-free, odor-free home. You can use it around your pets and kids without a second thought, so you won’t have to worry about their safety while using the house.

Moreover, with the Carpet and Rug Institute ‘s Seal of Approval, it’s certified safe and gentle for carpets. No harsh chemicals, no chlorine bleach, and no residue — just powerful cleaning that leaves your carpets, furniture, and upholstery looking and smelling fresh. Besides working very well on carpets, the cleaner’s oxygenated enzyme-based formula is great for concrete and tiles, hardwood and laminates, and bedding. Just spray the affected area and wait for a minimum of sixty minutes (concrete may need more absorption time; check the label), and forget that an accident ever happened!

BEST ENZYME URINE CLEANER

Kinzua Environmental Urine B-Gone

PHOTO CREDIT: Kinzua

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Why We Love

Highest enzyme count

Safe for pets and children

Multi-surface cleaner

Bio-degradable and non-toxic

Convenient for laundry

Eliminated odors at the source

But…

The child-proof cap may be difficult to remove

If you have a puppy who isn’t house-trained yet or a senior dog struggling with incontinence, then you must be wondering how to get rid of the urine smell. Here’s your answer: consider using the Kinzua Environmental Urine B-Gone — the best enzyme cleaner for dog urine. Its powerful formula boasts the highest enzyme count available, containing over 200 billion of these tiny cleaning champions that effectively tackle stains and odors from urine and feces.

This enzyme cleaner doesn’t just clean and deodorize the surface where messes happen but goes deep down into the surface layers and works its magic. The bio-based formula is also safe for your family and pets. This dog urine cleaner is biodegradable, non-toxic, and gentle when used as directed. You can safely use it on carpets, upholstery, laundry, drains, and more. Just add a cup to your laundry load or apply directly to soiled areas before washing.

BEST ODOR REMOVER

NATURE’S MIRACLE Stain & Odor Remover

PHOTO CREDIT: NATURE’S MIRACLE

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Why We Love

Fast-acting enzymes

Long-lasting cleaning

Can be used on a variety of surfaces

Safe for pets and home

Can be used daily

Available in two scents – light citrus and melon burst

But…

The nozzle may leak

Life with furry friends can be messy, but it shouldn’t force you to give up a fresh-smelling home — Nature’s Miracle Stain & Odor Remove can help you keep your space clean and odor-free. Its enzymatic formula works on a variety of unpleasant surprises — dog urine, feces, vomit, drool, and other organic stains. When used as directed, this trusted brand is safe to use around your furry family and doesn’t contain harsh chemicals that can damage your carpets or furniture.

Unlike other cleaners that mask odors, this cleaner utilizes a bacteria-based formula to produce enzymes that keep working as long as there’s a mess to eliminate — ensuring there is no lingering smell. Instead, it leaves behind a fresh, light citrus scent that keeps your home smelling clean and inviting. If you’re not a fan of citrus fragrance, the cleaner also comes in a melon burst scent, giving you the option to choose what works best for your household.

BEST STAIN REMOVER

Simple Solution Extreme Stain & Odor Remover

PHOTO CREDIT: Simple Solution

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Why We Love

Professional-strength formula

Multi-functional sprayer

Pro-bacteria & enzyme cleaning

Certified safe for rugs and carpets

Discourages repeat marking

Safe for pets and children

But…

May not work on all surfaces

If you’re looking for a powerful ally in the fight against pet messes, then Simple Solution Extreme Stain & Odor Remover might be the one for you. You’ll have no trouble getting rid of those pesky pet stains; it leaves both your carpets and furniture gleaming clean. It’s three times more powerful than their regular formula, so you know it means business! The pro-bacteria and enzyme formula breaks down and eliminates both new and old stains, leaving no trace of stinky pet urine , feces, or vomit behind. It also prevents repeat markings, meaning your pet won’t get lured by the scents and repeat their accidents at the same spot.

We love that this versatile cleaner has a multi-functional sprayer with three settings: Foam, which is ideal for upholstery and fabric surfaces; the mist setting is perfect for spot-cleaning carpets and area rugs; and stream, which targets those hard-to-reach areas or large spills. Plus, it has the Carpet and Rug Institute’s Seal of Approval. You can safely use it around your kids and pets, following the instructions, making it a worry-free cleaning solution.

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BEST ECO-FRIENDLY

Biokleen Bac-Out Carpet Stain + Odor Remover

PHOTO CREDIT: Biokleen

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Why We Love

Plant-based formula

Effective odor removal

Preferred by professional carpet cleaners

Pleasant scent

Green-Seal certified

Made using biodegradable ingredients

But…

Doesn’t come in a spray bottle

Harsh chemical cleaners may get the job done, but they are neither good for you nor the environment. The Biokleen Bac-Out Carpet Stain + Odor Remover is a powerful, plant-based formula that naturally tackles not just pet accidents but a variety of other household mishaps. Featuring a blend of live enzyme cultures, this cleaner effectively breaks down and absorbs organic materials, eliminating stains and odors at the source.

Because it is made with plant-based ingredients, Biokleen enzyme cleaner is absolutely safe to use around your family and pets. Carpets, area rugs, upholstery, garbage cans, laundry — all can benefit from the cleaner’s bioactive formula, which gets rid of the toughest odors and stains. Plus, it is also free from chemicals, artificial fragrances, and dyes, making it comprehensively eco-friendly.

BEST SCENTED CLEANER

ANGRY ORANGE Stain Remover Enzyme Cleaner

PHOTO CREDIT: ANGRY ORANGE

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Why We Love

Multi-surface use

Delivers up to 80 hours of freshness

Dual action targets stains and odors

Crisp Citrus scent

Safe for pets and children

No added bleach, sulfates, or parabens

But…

The scent may be overpowering for some

The ANGRY ORANGE Stain Remover & Enzyme Cleaner makes quick work of tough messes, giving you peace of mind and a cleaner home. Its dual-action formula fights tough stains and smells, including pet pee, poop, and puke. The enzyme-powered cleaner instantly removes odors and keeps your home smelling fresh for up to 80 hours.

Made with citrus enzymes and cold-pressed orange oils, it is safe for use around pets and children (when used as directed). The light citrus aroma offers a fresh change from the usual strong chemical odors. You can also use it on any conceivable surface where pet messes are likely to happen — carpets, hardwood floors, fabric, artificial turf, and more.

BEST FAST-ACTING

Sunny & Honey Pet Stain & Odor Miracle

PHOTO CREDIT: PLACEHOLDER

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Why We Love

Natural cleaning power

Leaping Bunny-certified

Non-toxic and biodegradable

Multi-surface cleaning

Fast-acting formula

Available in three fragrances

But…

Stubborn stains and odors may require repeat application

Much like its name, the Sunny & Honey Pet Stain & Odor Miracle really does work its magic on all kinds of pet messes, including doggy drool , pee, feces, and vomit. With its powerful, concentrated formula, you can easily eliminate organic stains and odors. Your carpets, upholstery, and nose will thank you! Need something that cleans both inside and out? This product handles carpets, wood floors, furniture fabrics, car interiors — even synthetic turf and deck planks!

The cleaner has the stamp of approval from Leaping Bunny and is made from quality ingredients. Its bio-enzymatic formula is non-toxic and biodegradable, which is harmless to both your loved ones and nature. That’s not all; this deodorizer utilizes essential oils to eliminate lingering odors and comes in three scents — fall spice, light lavender, and spring mint — making you confident that you will always have a nice-smelling home.

BEST FOR TOUGH STAINS

BUBBA’S ROWDY FRIENDS Stain and Odor Terminator

PHOTO CREDIT: BUBBA’S ROWDY

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Why We Love

Offers deep cleaning

Permanent odor removal

Safe for use around pets and children

Easy application

Professional-strength formula

Suitable to use on a variety of water-safe surfaces

But…

Slightly more expensive than other brands

This powerful enzymatic cleaner from Bubba’s Rowdy Friends is specifically formulated to tackle tough stains and stubborn odors caused by your furry friends. Sometimes, you need something with a lot more strength than temporary fixes, and this cleaner gets the job done — whether it’s set-in urine, feces, vomit, or drool.

This bio-enzymatic cleaner gets right down into the carpet fibers and padding, tackling stains and odors at their source to leave your carpets fresh. Crafted in the USA, this top-notch formula is perfect for households with pets and kids. Cleaning up is a breeze with this easy-to-use formula. You can quickly tidy up all kinds of water-safe surfaces without any hassle. Simply remove excess mess, apply the solution, let it work, and vacuum. Repeat for stubborn stains. No more hassle, just a fresh and clean home.

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How We Chose the Best Enzyme Cleaners

At DogTime, our experts curated this list of the best enzyme cleaners by assessing factors such as efficacy in eliminating pet stains and odors, certification from reputed bodies, safety for pets and children, fragrances, and overall cost. They further consulted with industry professionals to gain more insight into the top-selling products, using their guidance and experience to bring our readers the very best. When you choose one of our recommended products, you can rest assured that you’re making an informed purchase from the best brands available on the market.

FAQ

What cleaner is an enzyme cleaner?

All the cleaners listed here are enzyme cleaners. If a cleaner is enzymatic, it will say so on the label. These cleaners use natural enzymes to break down and eliminate pet mess stains and odors rather than masking them with chemicals.

Is Clorox an enzymatic cleaner?

No, Clorox is not an enzymatic cleaner. It is a brand known for its bleach-based products, which work by oxidizing and breaking down stains. It may not be safe for pets or some fabrics.

Is vinegar an enzyme cleaner?

Vinegar is a powerful cleaning agent but not an enzyme cleaner. While it can break down some stains and neutralize odors, it doesn’t use enzymes to target pet messes.

Does enzyme cleaner remove urine?

Yes, enzyme cleaners are effective pet urine removers! Enzymes break down the organic matter in urine, such as proteins and uric acid, eliminating both stains and odors at the source.

Is borax an enzyme cleaner?

Borax isn’t an enzyme cleaner. It is a mineral compound used in household cleaners or laundry boosters. While it can be effective for cleaning and deodorizing, it does not contain enzymes like enzymatic cleaners.

Are enzyme cleaners safe?

Enzyme cleaners are generally safe for pets and children when used as directed. However, it’s always a good idea to read the instructions on the label, test a small area first, and avoid direct contact with pets and kids.

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