GLP-1 receptor agonist use in diabetes and obesity has soared, and indications are now expanding into liver diseases, specifically metabolic dysfunction-associated steatohepatitis. However, the jury is still out on its benefits. With the recent FDA approval of resmetirom (Rezdiffra, Madrigal Pharmaceuticals) for the treatment for MASH — formerly known as...

MASH therapies still needed despite boom in GLP-1 use in liver disease

Millions of dollars have been spent trying to find medications that could treat this complex disorder. The focus has been on drugs for more severe disease, as it leads to complications, and early stages have been somewhat ignored. The hepatology field wants to target people who have advanced fibrosis, because...

Manage lifestyle early and aggressively to prevent, instead of treat, fatty liver

Healthline

Fungal meningitis is an inflammation of the membranes that surround the brain and spinal cord. It results from a fungal infection.

What You Need to Know About Fungal Meningitis

Graves’ disease occurs when the thyroid overproduces thyroid hormones, causing hyperthyroidism. Hashimoto’s disease includes an underactive thyroid that does not produce enough thyroid hormones, causing hypothyroidism. These are two different types of thyroid disease. Graves’ disease and Hashimoto’s disease are both autoimmune conditions that affect the thyroid gland....

Graves' disease vs. Hashimoto's disease: What to know

rolling out

Kidney disease is a growing health concern worldwide, affecting millions of people. It is often referred to as a silent killer because symptoms may not appear until significant damage has been done. Understanding how kidney disease starts with common unhealthy behaviors is crucial for prevention and early intervention. This article delves into how unhealthy habits can lead to kidney disease, highlighting the importance of adopting healthier lifestyles to protect this vital organ.

Kidney disease starts with common unhealthy behaviors

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Total Apex Sports & Entertainment

There are certain zodiac signs that most people are careful with because of their fiery and low tolerance levels. You can hardly mess with individuals with such signs without getting a backlash. Whether they are in work environments or family settings, they do not hesitate to set boundaries and protect them.

5 Zodiac Signs You Don't Mess With

Polyps in the colon and rectum (together called colorectal polyps) are common in people over age 50. They are usually noncancerous, but certain characteristics can increase the likelihood of a polyp becoming cancerous. The risk of a polyp becoming cancerous increases with size. Polyps that are 10 millimeters (mm) or...

Colon Polyp Size Chart to Gauge Risk

For years, gout was considered a rich man’s illness, the result of overindulging in rich foods. But this painful form of inflammatory arthritis actually is an equal opportunity disease. Apart from causing joint pain, it may be the canary in the coal mine for heart disease—similar to other inflammatory conditions, such as rheumatoid arthritis, gout is a risk factor for heart problems. We asked rheumatologist Puja Khanna, MD, MPH, to explain how to avoid and treat gout.

Gout …and Its Link to  Inflammation

Harvoni (ledipasvir/sofosbuvir) is a prescription drug that’s used to help treat certain types of hepatitis C. The drug comes as oral tablets and oral pellets. You usually take the drug once per day. Harvoni is used in adults and children ages 3 years and older to help treat:. hepatitis...

Dosage Details for Harvoni

Denver, CO

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David Heitz

A dangerous drug that is being mixed into fentanyl is causing those who inject it to develop a rash of sores that resembles a case of flesh-eating bacteria. People experiencing homelessness around Denver can sometimes be seen with these bloody, weeping wounds. I recently mentioned this phenomenon to a fentanyl user who told me about the xylazine connection.

Denver homeless people suffer sores as xylazine enters fentanyl supply

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	Uterine fibroids, though usually non-cancerous, have a profound impact on a your body. They can cause pelvic pain, heavy menstrual bleeding, and weight gain in the abdomen. For many people, noticing an unexpected increase in weight can be puzzling and distressing, particularly when the scale seems to climb without a clear reason. The relationship between uterine fibroids and weight gain is complex, rooted in the physical presence of these benign tumors, which can grow as large as a melon, or even a basketball, according to Dr. Mache Seibel, a board-certified gynecologist and expert in reproductive medicine. Can Uterine Fibroids Cause...

Yes, Uterine Fibroids Can Cause Weight Gain — Here’s What You Can Do About It

Although loss of bone density can seem inevitable with aging, especially if you’re a woman, specific treatments may slow its progression. Hormone therapy, for instance, has a growing body of research behind it, with outcomes that show promise for osteoporosis, a condition characterized by brittle and breakable bones. "Hormone...

Should You Take Hormone Therapy for Osteoporosis?

Pancreatic cancer is a daunting diagnosis that affects thousands of people worldwide every year. One of the most challenging aspects of this disease is its subtlety; the symptoms often mimic those of other, less severe conditions. This similarity can lead to delayed diagnosis and treatment, significantly impacting the prognosis. Understanding why pancreatic cancer symptoms resemble other diseases’ symptoms is crucial for early detection and better outcomes. This article will delve into the reasons behind this symptom overlap, explore common symptoms of pancreatic cancer, and provide insights on differentiating these symptoms from other ailments.

Why pancreatic cancer symptoms are similar to other diseases

Review the multiple uses of metformin. A recent article on the multiple uses of metformin brings up the important topic of repurposing medications.1 Repurposing has been around since the advent of modern medicine. One prominent example is the use of chlorpromazine (CPZ) as an antipsychotic.2 Chlorpromazine was first synthesized in 1951 as a potentiator of general anesthesia.2 The psychiatric benefits were found later by Henri Laborit, a surgeon in the French army. He was doing research with artificial hibernation in prevention of surgical shock.2 Laborit employed the drug as an adjunct to anesthetics.2 He observed that CPZ at doses of 50 mg to 100 mg produced a lowering of body temperature, sedation, and disinterest without loss of consciousness.2 He was able to persuade his colleagues in the military hospital in Paris to try CPZ in the treatment of one of their patients who was experiencing psychotic agitation.2 Laborit hypothesized that since cooling with water had been used to treat agitation in France, the drug would have a similar effect.2 The mechanism of action was not fully known, and it was thought that it worked in controlling agitation because of its cooling effect and induction of “artificial hibernation” in patients.2 The pharmacological mechanism was not fully understood until many years later and the way it has impacted the practice of psychiatry needs no introduction. These “happy accidents” in medicine have played a vital role in getting where we are right now compared with just 50 years ago. This begs the question, are we onto another “happy accident” with metformin? There is an accumulating body of evidence that metformin may have benefits in aging that are beyond its effect on glycemic control.3.

Metformin, Inflammation, the Gut Microbiome, and Health Span: Connecting the Dots

Do you find it difficult to find what you are looking for? Is it difficult to find ways to organize your house, your office, and your life? Who are those managers of organization? I know I see them all of the time, I'm sure you do too. Those people who seem to always have it all together. Those people with planners, calendars, organized shelves and closets, nice neat cars. Who are they? Let's find out.

Top 3 Most Organized Zodiac Signs

Kentucky State

Northern Kentucky Tribune

Increasing state cigarette taxes has proven to be an effective policy to decrease smoking rates, and it appears that is also true in Kentucky. Nearly 30 percent of Kentucky adults smoked in 2011, two years after the legislature had doubled the cigarette tax to 60 cents a pack. Following a 50-cent increase to $1.10 in 2018, the state’s adult smoking rate fell to 17.4% in 2022, the last year for which a rate is available.

Cigarette tax collections in KY dropped after last two tax increases; smoking rate declining

Kentucky’s Community Actions Partnerships have announced the starts date for the Low-Income Home Energy Assistance Program (LIHEAP) Summer Subsidy, aimed at helping Kentucky households offset summer cooling costs.

LIHEAP Summer Subsidy program to help with summer cooling costs to begin enrollment July 16

Scituate, MA

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Dianna Carney

The Scituate Animal Shelter of Massachusetts has announced a heartwarming and adorable event that will both raise money for the local animal shelter while also socializing a few of their tiniest furry friends. The local animal shelter explains, "We need help socializing 12 adorable kittens! Your job would be to hang out with them, play with them and pet them!"

Local Animal Shelter Announces Adorable "Play With Kittens" Event

Supplements, such as curcumin and vitamin D, may help reduce stiffness and pain in people with osteoarthritis. form of arthritis and typically causes joint pain and reduced range of motion in one or more joints. Many people with OA choose to adapt their diet to include anti-inflammatory foods, such as fruits, vegetables, beans, and whole grains. Adding supplements to the diet is also popular.

Do supplements help with the symptoms of osteoarthritis?

New York Post

She’s giving obesity medications another shot.

Diane Schram, 64, lost 25 pounds with Ozempic and tirzepatide, a similar medication. After plateauing on those two drugs, Schram is trying a new experimental drug that’s being hailed as better than Ozempic. 

Eli Lilly’s retatrutide, which is in clinical trials, may help users shed up to 24% of their body weight after 48 weeks. Schram is taking it at Renew Body Contouring and MedSpa in Houston as part of a clinical research study, the Fox affiliate in Houston reports.

“The new retatrutide has an ability to help you retain muscle and now you’re having less...

I plateaued on Ozempic — now I’m trying an experimental new obesity drug

NewsBreak

What to Know About Semaglutide for Fatty Liver Disease

Semaglutide is a prescription medication used to treat type 2 diabetes. It may also help people with overweight or obesity lose weight, and it may help...

What to Know About Semaglutide for Fatty Liver Disease

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