Light can be used to activate drugs in specific parts of the body through photopharmacology. This innovative approach involves modifying the chemical structure of a drug by adding a light-activated molecular switch, such as azobenzene. This allows the drug to be activated only when exposed to a specific color of light, rather than in the dark.

Research team develops light-activated compounds to treat neuropathic pain

Chronic pain, particularly neuropathic pain resulting from nerve damage, significantly impacts quality of life for many individuals. Conventional treatments, such as opioids, often come with severe side effects like addiction, tolerance, and constipation, making them less ideal for long-term management. Recent research published in the journal PAIN explores an alternative:...

Cannabis terpenes offer new hope for neuropathic pain relief

Semaglutide, the active ingredient in Ozempic and Wegovy, is associated with a rare blinding disease, according to new research. The condition, known as non-arteritic anterior ischemic optic neuropathy (NAION), causes sudden blindness due to a lack of blood flow to the optic nerve. Despite the findings, the study does not...

GLP-1 Drugs Like Wegovy, Ozempic Potentially Linked to Blinding Disease

Everyday Health

Now in clinical trials, this new medication can lead to impressive weight loss while preserving more lean muscle than its rivals.

Is This Drug the Next Ozempic?

Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows. In a study, women with chronic pelvic pain who had a naturally occurring variation of a gene, known as Neuregulin 3, in their DNA were more likely to experience relief after taking the painkilling drug gabapentin.

Tell-tale gene affects success of drug used to treat chronic pain

ScienceAlert


Researchers have discovered how a cell surface protein called Aplp1 can play a role in spreading material responsible for  Parkinson's disease from cell-to-cell in the brain.
Promisingly, an FDA-approved  cancer drug that targets another protein called Lag3 – which interacts with Aplp1 – blocks the spread in mice, suggesting a potential therapy may already exist.



					
			

In a new paper, an international team of scientists describes how the two proteins work together to help harmful alpha-synuclein protein clumps get into brain cells.
"Now that we know how Aplp1 and Lag3 interact, we have a new way of understanding how alpha-synuclein contributes to...

Parkinson's Discovery Suggests We May Already Have an FDA-Approved Treatment

Developed by Vertex Pharmaceuticals, suzetrigine is a promising new class of pain medicine that has been gaining attention for its innovative mechanism of action and reported efficacy; suzetrigine might offer hope for those struggling with acute pain issues who want to avoid opioids and NSAIDs. The reliance on opioids and...

A New Class of Medicine for Pain Relief On The Horizon

B12 is a vitamin that helps the body maintain essential systems, such as the central nervous system. A B12 deficiency in women can cause symptoms such as fatigue and more severe complications. The body needs B12 to function healthily, and a B12 deficiency can cause conditions such as severe neurological...

What are the symptoms of B12 deficiency in females?

Chicago, IL

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Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

rolling out

Managing glucose levels is crucial for maintaining overall health, but many people are unaware of the joint pains associated with glucose health issues. These pains can range from mild discomfort to severe, life-altering conditions. Understanding these pains, their causes, and how to manage them is essential for anyone with glucose-related health problems.

Common pains linked to glucose health issues

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Total Apex Sports & Entertainment

What makes a Zodiac Sign low maintenance? Independence can make someone low maintenance. Someone who is reliable, dependable, and punctual, can make someone low maintenance. Someone who tends to want to do things on their own can be low maintenance. Low-maintenance people tend to be those people who do on their own but are not necessarily alone. They rarely need or ask for help. They are self-motivated, often energetic, and can be considered leaders is many cases. Now me, some say I am low maintenance and others say I’m high maintenance. Maybe I’m both. Let's see what zodiac signs are considered low-maintenance.

5 Zodiac Signs That Are Low Maintenance

Police say the remains discovered in a west London flat and Bristol belong to the same two men.

More human remains found as police name suspect

Medical News Today

Researchers say MRI scans can help identify brain atrophy in people with Parkinson's and help predict the progression of the disease as well as what treatments might be most effective

How MRI scans can help with Parkinson's disease diagnosis, treatments

The following is a summary of “Myofascial pain – A major player in musculoskeletal pain,” published in the April 2024 issue of Rheumatology by Lam et al. Myofascial pain syndrome is a prevalent soft tissue disorder characterized by the development of localized and referred musculoskeletal pain, primarily originating from trigger points within skeletal muscles or their associated fascia. These trigger points, often palpable as taut bands or nodules, are hypersensitive areas that can provoke pain locally or refer pain to distant sites, contributing significantly to both acute and chronic pain burdens in clinical settings. The syndrome can manifest independently as a primary pain condition or coexist as a secondary phenomenon alongside other acute or chronic musculoskeletal disorders, amplifying the complexity of pain management strategies.

Myofascial Pain Syndrome: Significance in Musculoskeletal Pain Management

Early on during the coronavirus pandemic, there were reports of cases of persistent post-infection symptoms. The World Health Organization (WHO) refers to such new or persistent symptoms twelve weeks after a corona infection that cannot be explained by other causes as a post-COVID-19 condition. In a recent study, scientists led by the University Medicine Halle evaluated the information from 109,707 participants in the German National Cohort (NAKO Gesundheitsstudie) on their self-reported health status with respect to post-infection symptoms. The survey took place in autumn 2022, in retrospect of the pandemic.

Study on post-COVID-19 condition: Which factors have an impact on the risk

New York City, NY

Cheryl E Preston

Yesterday was the third time this year that an ad stating Chelsea Clinton lives in a beautiful Virginia home popped up on my laptop. My computer did not warn me this was a dangerous site, so this time, I clicked on the link.

Chelsea Clinton is rumored to be living in Virginia but probably still in NYC

DogTime

Xylazine — also known by its brand name Rompun® — is a drug used as a sedative, analgesic, and muscle relaxant in dogs. Initially developed for use in large animals like horses and cattle, it has also proven to be effective in canines. As an alpha-2 adrenergic agonist, xylazine works by depressing the central nervous […]
The post Xylazine for Dogs: Uses, Dosage, & Side Effects appeared first on DogTime.

Xylazine for Dogs: Uses, Dosage, & Side Effects

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NewSantaAna

The FBI has seen a rise in scams targeting timeshare owners. In this kind of scam, criminals con these part-time property owners into shelling out hefty sums of cash, all under false pretenses related to their timeshare properties.

FBI warns that Mexican cartels are targeting Americans with timeshare scams

Diabetic neuropathy can worsen over a period of many years. If it continues to progress, it can lead to potentially serious complications. Managing your blood sugar can help slow progression, especially for type 1 diabetes. Untreated diabetes can lead to a range of complications. These include damage to the nerves...

Diabetic Neuropathy Progression: What to Know

Nagoya University researchers found that deficiencies in gut bacteria genes for vitamins B2 and B7 are linked to Parkinson’s disease, suggesting that B vitamin supplementation could be a potential treatment. A study conducted by the Nagoya University Graduate School of Medicine in Japan has discovered a connection between gut...

New Study Links Gut Vitamin B Deficiency to Parkinson’s Disease

NewsBreak

Light-activated drugs against neuropathic pain

Institute for Bioengineering of Catalonia (IBEC) Light can be used to activate drugs in specific parts of the body through photopharmacology. This innovative approach involves modifying...

Light-activated drugs against neuropathic pain

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