Approximately one-quarter of strokes in the U.S. do not require statins for secondary prevention. Statin initiation in this population could lead to thousands of adverse events every year. Statin initiation in patients with stroke etiologies not indicated for secondary prevention with statin therapy could hypothetically cause thousands of adverse events...

Statin use when not indicated for certain strokes could cause adverse events

A new study suggests a short course of immunotherapy before surgery may significantly improve outcomes in patients with high-risk melanoma. Neoadjuvant immunotherapy consisting of cobimetinib (Cotellic) and atezolizumab (Tecentriq) with or without vemurafenib (Zelboraf) followed by therapeutic lymph node dissection (TLND) led to robust pathologic complete response (pCR) and major pathologic response (mPR) rates in patients with resected stage III melanoma, according to findings from the phase 2 NeoACTIVATE trial (NCT03554083).1.

Neoadjuvant Immunotherapy Trial Sees High pCR Rates in Stage III Melanoma

Early findings from a small clinical trial provide evidence that a new cellular immunotherapy approach may be effective in treating metastatic solid tumors. In the trial, researchers from the National Institutes of Health (NIH) genetically engineered normal white blood cells, known as lymphocytes, from each patient to produce receptors that recognize and attack their specific cancer cells. These initial findings are from people with metastatic colorectal cancer who had already undergone multiple earlier treatments. The personalized immunotherapy shrank tumors in several patients and was able to keep the tumors from regrowing for up to seven months. The findings were published July 11, 2024, in Nature Medicine.

Immunotherapy approach shows potential in some people with metastatic solid tumors

Los Angeles, CA

In this episode of Targeted Talks, Omid Hamid, MD, discusses data supporting the use of lifileucel for the treatment of advanced melanoma. In this episode of Targeted Talks, Omid Hamid, MD, chief of translational research and immunotherapy and director of melanoma therapeutics at The Angeles Clinic and Research Institute in Los Angeles, California, delves into the mechanism of action, supporting data, and approval of lifileucel (LN-44; Amtagvi).

Advancing Melanoma Treatment: Hamid on Lifileucel's Role

During a Case-Based Roundtable® event, Michael A. Postow, MD, discussed an indirect treatment comparison of nivolumab plus relatlimab vs nivolumab plus ipilimumab in patients with advanced melanoma in the first article of a 2-part series. Targeted Oncology: Why is it valuable to indirectly compare the experimental arms of the...

Similar Efficacy in Melanoma Shown in Indirect Comparison of PD-1/LAG3 vs PD-1/CTLA-4

New York City, NY

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Cheryl E Preston

Yesterday was the third time this year that an ad stating Chelsea Clinton lives in a beautiful Virginia home popped up on my laptop. My computer did not warn me this was a dangerous site, so this time, I clicked on the link.

Chelsea Clinton is rumored to be living in Virginia but probably still in NYC

Diabetic neuropathy can worsen over a period of many years. If it continues to progress, it can lead to potentially serious complications. Managing your blood sugar can help slow progression, especially for type 1 diabetes. Untreated diabetes can lead to a range of complications. These include damage to the nerves...

Diabetic Neuropathy Progression: What to Know

Medical News Today

Researchers say a new blood test may be able to detect the potential progression of Parkinson's disease up to 7 years before symptoms appear

New blood test could predict Parkinson’s disease 7 years before symptoms

Chicago, IL

Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

DSP-5336 targets the menin and mixed-lineage leukemia protein interaction, crucial in various biological processes, including cell growth and genomic stability. The FDA has granted Fast Track Designation to Sumitomo Pharma America’s DSP-5336, an investigational small molecule inhibitor for the treatment of relapsed or refractory acute myeloid leukemia (AML) with KMT2A rearrangement (MLLr) or nucleophosmin mutation (NPM1m). According to the company, DSP-5336 targets the menin and mixed-lineage leukemia (MLL) protein interaction, which is considered vital in a variety of biological processes, including cell growth and genomic stability.1.

FDA Grants Fast Track Designation to Sumitomo Pharma’s Novel Treatment for Patients with Relapsed or Refractory Acute Myeloid Leukemia

Virginia State

Mercurochrome and Merthiolate were in medicine cabinets in many Virginia homes decades ago. They were in bottles with droppers that gallons the red liquid. Looking at that old bottle in the above image brings back many memories.

Mercurochrome and Merthiolate once were in many Virginia homes

Prentiss County, MS

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Mississippi News Group

Written with A.I. assistance. According to the Prentiss County Sheriff's Department, on July 2, 2024, Deputy Hunter Arnold and Josh Brumley were conducting a routine safety checkpoint with other deputies at the intersection of highway 30 east and highway 365. The operation took an unexpected turn when a vehicle driven by April Nicole Storment approached.

Drug Possession Arrest Made During Safety Checkpoint in Prentiss County

The FDA declined to approve sotagliflozin for type 1 diabetes in a complete response letter issued in March 2019. Lexicon Pharmaceuticals resubmitted the NDA for sotagliflozin to treat type 1 diabetes and CKD. A new drug application for sotagliflozin as an adjunct to insulin therapy for adults with type 1...

FDA receives resubmitted NDA for sotagliflozin to treat type 1 diabetes and CKD

Kentucky State

Northern Kentucky Tribune

Kentucky’s Community Actions Partnerships have announced the starts date for the Low-Income Home Energy Assistance Program (LIHEAP) Summer Subsidy, aimed at helping Kentucky households offset summer cooling costs.

LIHEAP Summer Subsidy program to help with summer cooling costs to begin enrollment July 16

A high-risk cohort of beneficiaries with chronic kidney disease (CKD) stage 3 have a profile similar to patients with CKD stages 4 and 5, indicating potential benefit of earlier nephrology intervention. ABSTRACT. Objectives: Chronic kidney disease (CKD) is a widely prevalent disease with heterogeneous disease progression. Prior study findings suggest...

Identifying Chronic Kidney Disease Stage 3 With Excess Disease Burden

Bacon County, GA

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Daily Coffee Press

On Monday, a search at a Bacon County home by investigators resulted in the discovery of a large quantity of illegal drugs, including methamphetamine and cocaine. However, the suspects are currently not in custody.

Drug Bust Uncovers Methamphetamine and Cocaine in Bacon County Residence

The key factor may be the control of inflammation. Investigators studying the effects of Janus kinase inhibitor (JAKi) therapy in patients with autoimmune diseases reported that these patients may have a lower risk of developing age-related macular degeneration (AMD).1 The key factor may be the control of inflammation, according to the first study author Joelle A. Hallak, PhD who is from Health Economics and Outcomes Research, AbbVie, North Chicago, IL.

Study suggests JAK inhibitors may reduce AMD risk in autoimmune disease patients

A clinical practice update from the American Gastroenterological Association is providing clinicians with an overview of the diagnosis and management of CVS. The American Gastroenterological Association (AGA) has released new clinical guidance to help clinicians and patients recognize the signs and symptoms of cyclic vomiting syndrome (CVS).1. The clinical practice...

Cyclic Vomiting Syndrome Clinical Practice Update Guides Diagnosis, Management

Oregon State

NewsByJoshua

With scorching heatwaves sweeping across the country, drivers are being advised to take their car's thermometer readings with a grain of salt. While your dashboard might display a temperature that seems outrageously high, experts suggest not relying on it for an accurate outdoor temperature gauge.

Drivers cautioned not to use a standard car feature on hot days - opt for your phone instead

California State

Alameda Post

California regulators just stopped AT&T from pulling the plug. California’s Public Utilities Commission on June 20 rejected AT&T’s application to stop providing landlines and other services in areas where there is no other option.

Still Need Your Landline?

NewsBreak

Phase 3 VERIFY Trial Investigates Rusfertide’s Potential in Polycythemia Vera

In an interview, Aniket Bankar, MD, discussed the background, design, and goals of the phase 3 VERIFY trial of the hepcidin mimetic rusfertide for the treatment...

Phase 3 VERIFY Trial Investigates Rusfertide’s Potential in Polycythemia Vera

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