Mazyar Shadman, MD, MPH, describes his clinical approach to treating patients with high-risk CLL/SLL, including those with or without del(17p) or TP53 mutations. Video content above is prompted by the following questions:. How would you describe your current clinical approach for high-risk patients with CLL/SLL, including those with or without...

Clinical Approaches in High-Risk Patients with CLL/SLL

Laura W. Goff, MD, MSCI, MMHC, discusses the onslaught of treatment sequencing available in gastrointestinal cancer. Treatment options have expanded over the past few decades across many cancer types. Although these advances provide new opportunities for patients, they also pose new challenges for treatment sequencing for providers. In this article, Laura Goff, MD, MSCI, MMHC, discusses the current state and future directions of treatment sequencing in lower gastrointestinal (GI) cancers.

An Embarrassment of Riches Treatment Sequencing in Gastrointestinal Cancers

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Thomas Smith

Spotting a few bugs in the house is typically a nuisance, but there's one in particular that should ring alarm bells for homeowners. If you come across the bug in the photo above, it's time to call in a professional.

Study This Photo--If You Find This Bug In Your House, You Need To Call in a Pro

Georgia State

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Tallahassee, FL

Daily Coffee Press

The FBI is investigating the disappearance of a now 13-year-old girl who went missing from Florida last year and has ties to Georgia and Tennessee. A $15,000 reward is being offered to anyone with information that can lead to her location.

FBI Investigating Disappearance of 12-Year-Old Girl Who Has Ties to Georgia

Ocilla, GA

Last Thursday, agents from the South Central Drug Task Force (SCDTF) made an arrest following a successful execution of a search warrant at a residence in Ocilla. According to officials, the search yielded a significant quantity of drugs, including tablets suspected to contain fentanyl, associated with a criminal street gang.

Successful Drug Bust in Ocilla Leads to Arrest Linked to 'Local Criminal Street Gang'

Kentucky State

Northern Kentucky Tribune

Kentucky’s Community Actions Partnerships have announced the starts date for the Low-Income Home Energy Assistance Program (LIHEAP) Summer Subsidy, aimed at helping Kentucky households offset summer cooling costs.

LIHEAP Summer Subsidy program to help with summer cooling costs to begin enrollment July 16

Jacksonville, FL

Jacksonville Today

A man died in police custody Sunday after he was arrested when he scuffled with firefighters and police, the Jacksonville Sheriff’s Office said. Joseph Lawson, 43, was the second person to die in the past week while in police custody. Both were hospitalized at the time they died, the Sheriff’s Office said.

Suspect dies in custody; he’s the second in six days

Washington State

Mill Creek, WA

Timothy A Gruver

The Washington State Department of Labor & Industries reported on Wednesday that it fined four roofing contractors more than a million dollars for letting their workers perform on top of homes without fall protection gear, among other safety violations.

Roofing Companies Fined $1.27M for Endangering Workers

Chicago, IL

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Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

Aurora, CO

David Heitz

Aurora’s pallet shelters for people experiencing homelessness, which only allow a maximum 30-day stay, have been cycling the same individuals in and out, city staff told council members Thursday. Many return to street encampments when their time in the pallet shelter runs out, Jessica Prosser, homeless services director for the city, said. Then, the city sweeps the encampment again, and they get to come back to the shelter for another 30 days, Prosser explained. This process can repeat multiple times.

Aurora pallet shelters a revolving door for homeless

Health

Reviewed by Ivy Kwong, LMFTReviewed by Ivy Kwong, LMFTIrritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are two chronic gastrointestinal disorders that share some overlapping symptoms, like abdominal pain, bloating, and diarrhea. While IBS and IBD have similar symptoms and acronyms, they are two distinct conditions with different underlying causes and treatment approaches. IBS is a functional disorder, meaning it affects how the intestines work but doesn't cause inflammation. IBD is an inflammatory disease that damages the gastrointestinal (GI) tract. In the United States, IBS affects between 25-45 million people, and IBD affects more than 3 million people.Symptoms of IBS vs....

What Is the Difference Between Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD)?

Savannah, GA

Newly returned indictments in the Southern District of Georgia include felony charges for illegal firearms possession and drug distribution, while additional defendants have been sentenced to federal prison or await further proceedings after pleading guilty to federal gun charges.

Federal Charges in Southern GA: Indictments and Sentences for Firearms and Drug Offenses

Alameda, CA

Alameda Post

Just look at that beautiful pup! Lima is an adorable 5-month-old Husky who is smart, friendly, and a total sweetheart. It’s hard to believe this sweet girl was brought to FAAS after being abandoned in a grocery store parking lot, tied to a pole with an electrical cord used as a leash. She was just a few months old.

Lima is Looking for Love

California State

The HD Post

CALIFORNIA – Starting July 1, landlords will only be allowed to collect one month’s rent for the security deposit on a rental property. Assembly Bill 12, signed into law last October, says regardless of whether the residential property is unfurnished or furnished, only one month’s rent can be charged in addition to any rent for the first month paid on or before initial occupancy.

Law limiting security deposits goes into effect July 1

Gov. Andy Beshear announced on Thursday the successful launch of a statewide drug operation by the Kentucky State Police (KSP) known as “Operation Summer Heat,” following a three-month investigation into suspected drug trafficking rings.

KSP’s Operation Summer Heat makes 206 drug trafficking arrests, saving lives in safer state

Discuss the data that was presented at the 2024 ASCO Annual Meeting on the progression-free survival from the phase 3 trial LAURA of osimertinib in patients with unresectable stage III EGFR-mutated NSCLC without progression after definitive CRT. What are your key takeaways from this study and how will it impact...

ASCO 2024: Key Findings of the LAURA Trial on7:19 Osimertinib for EGFR-Mutated NSCLC

DSP-5336 targets the menin and mixed-lineage leukemia protein interaction, crucial in various biological processes, including cell growth and genomic stability. The FDA has granted Fast Track Designation to Sumitomo Pharma America’s DSP-5336, an investigational small molecule inhibitor for the treatment of relapsed or refractory acute myeloid leukemia (AML) with KMT2A rearrangement (MLLr) or nucleophosmin mutation (NPM1m). According to the company, DSP-5336 targets the menin and mixed-lineage leukemia (MLL) protein interaction, which is considered vital in a variety of biological processes, including cell growth and genomic stability.1.

FDA Grants Fast Track Designation to Sumitomo Pharma’s Novel Treatment for Patients with Relapsed or Refractory Acute Myeloid Leukemia

Massachusetts State

Dianna Carney

Chloe, a 9 to 10-week-old puppy, is the last of her litter and is eagerly looking for a forever home. Sandy Paws Rescue Inc., a dedicated foster-based rescue in Massachusetts, recently shared Chloe's story and her endearing qualities.

Meet Chloe: The 10-Week-Old Puppy Who Is The Last Of Her Litter Looking For Love

In an interview, Aniket Bankar, MD, discussed the background, design, and goals of the phase 3 VERIFY trial of the hepcidin mimetic rusfertide for the treatment of patients with polycythemia vera. The phase 3 VERIFY trial (NCT05210790) is evaluating treatment with rusfertide (PTG-300), a hepcidin mimetic for the treatment of...

Phase 3 VERIFY Trial Investigates Rusfertide’s Potential in Polycythemia Vera

Coral Gables, FL

Edmond Thorne

Tragic End for South Florida Hispanic Building Tycoon Sergio Pino. Fort Lauderdale, FL - In a shocking turn of events, prominent South Florida homebuilder Sergio Pino was found dead in his Coral Gables home on Tuesday morning. The Miami-Dade County Medical Examiner's Office confirmed that Pino died from an apparent suicide.

South Florida Tycoon Dead After FBI Raids on Homes and Office

NewsBreak

SEQUOIA Arm D Study: Zanubrutinib plus Venetoclax in Treatment-Naive CLL/SLL with del(17p) and/or TP53 Mutations

Please briefly discuss the latest results from the SEQUOIA Arm D...

SEQUOIA Arm D Study: Zanubrutinib plus Venetoclax in Treatment-Naive CLL/SLL with del(17p) and/or TP53 Mutations

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