Developed by Vertex Pharmaceuticals, suzetrigine is a promising new class of pain medicine that has been gaining attention for its innovative mechanism of action and reported efficacy; suzetrigine might offer hope for those struggling with acute pain issues who want to avoid opioids and NSAIDs. The reliance on opioids and...

A New Class of Medicine for Pain Relief On The Horizon

ScienceAlert


The United States is in the throes of a deadly opioid  epidemic that could claim the lives of millions by 2029.
A recent breakthrough in overdose treatments could offer a new strategy for the public health emergency.



					
			

The study, led by researchers at Stanford University and Washington University in St. Louis, introduces a novel drug, called compound 368, that seems to greatly enhance the life-saving effects of naloxone in mice.
Naloxone (brand name Narcan) is one of the most common and effective opioid overdose treatments available today in the US without a prescription. It is also an opioid, but instead of activating...

Breakthrough Drug Could Have The Power to Reverse Opioid Overdoses

HealthDay News — For patients presenting with acute pain, the quantity of opioids consumed during 2 weeks after emergency department discharge is low and varies across pain conditions, according to a study published online in CMAJ, the journal of the Canadian Medical Association. Raoul Daoust, MD, from Sacré-Coeur Hospital...

Low Quantity of Opioids Used After ED Discharge for Acute Pain

The FDA on Tuesday rejected Orexo’s application for OX124, its high-dose naloxone nasal spray for the rescue treatment for opioid overdose. While the regulator’s Complete Response Letter (CRL) does not indicate a need for additional clinical and non-clinical studies, the FDA is requiring another “human factors” study before the company files another application. This request is “in line with previous communication,” Orexo noted in its news release, adding that it has already completed such a study.

Orexo’s Opioid Overdose Nasal Spray Fails FDA Review for Second Time

Scientists have developed new biosensors that enable real-time tracking of opioid signaling in the brain, offering profound insights into the effects of opioids and enhancing the development of targeted therapeutics. New findings from a researcher at the Max Planck Florida Institute for Neuroscience could revolutionize our understanding of how opioids...

Revolutionary Opioid Research Could Transform Addiction Treatment

TheConversationAU

Earlier this month, drugs sold as cocaine in Melbourne were found to be contaminated with a powerful group of opioids, known as nitazenes.

These new synthetic drugs were also the suspected cause of four people being hospitalised in Sydney in May. And in April, nitazenes were found in drugs used by around 20 people who overdosed in outer Sydney.

So what are nitazenes, why are they so dangerous, and how can we minimise the harms they cause?



What are nitazenes?

Nitazenes are a group of synthetic opioids. This means they’re made in a lab (distinct from morphine or heroin which come from the opium...

Cocaine is being contaminated with powerful opioids called nitazenes. Here’s why it’s a dangerous mix

Pawtucket, RI

In Pawtucket, R.I., near a storefront advertising “free” cell phones, J.R. sat in an empty back stairwell and showed a reporter how he tries to avoid overdosing when he smokes crack cocaine. (NPR is identifying him by his initials because he fears being arrested for using illegal drugs.)

Stimulant users caught up in fatal 'fourth wave' of opioid epidemic

24/7 Wall St.

When it comes to our pets, we only want what’s best for their health and wellbeing. One of the most important decisions to make as a pet owner is which food to invest in. We all know that pets can be costly, but you don’t need to break the bank to feed them high-quality food. There […]
The post Avoid All Pet Food Brands Except These 4 appeared first on 24/7 Wall St..

Avoid All Pet Food Brands Except These 4

Pima County, AZ

Picture Rocks, AZ

Law & Crime

A father is under arrest after his 9-year-old son's decomposing remains were allegedly found on a couch inside a home filled with garbage, "soiled diapers," "one gallon bottles" of urine, and spiders.
The post ‘Should have called somebody’: 9-year-old boy found sitting upright and decomposing on couch in home filled with black widow spiders, deputies say first appeared on Law & Crime.

'Should have called somebody': 9-year-old boy found dead sitting upright on couch in home filled with black widow spiders, deputies say

DogTime

Dexmedetomidine for dogs is an FDA-approved sedative, pain reliever, and anesthetic adjunct used in veterinary practices. It acts as a highly selective alpha-2 adrenergic agonist, helping to calm the dog and reduce anxiety. The drug can be found under brand names like Dexdomitor® and Sileo®. Here’s what you should know about dexmedetomidine’s uses, dosage, and […]
The post Dexmedetomidine for Dogs: Uses, Dosage, & Side Effects appeared first on DogTime.

Dexmedetomidine for Dogs: Uses, Dosage, & Side Effects

The Independent

Three deaths in the same northeastern town have potentially been linked to the same batch of suspected dangerous drugs, police have warned.Northumbria Police said that two men and a woman were found dead after “fatal medical episodes” in South Shields, South Tyneside.The force said that while the exact circumstances remain “unexplained”, detectives are exploring the possibility that all three could be linked to the same batch of drugs.The next of kin of a man in his 30s, a man in his 40s and a woman in her 30s were informed after the three deaths were confirmed on Thursday afternoon. Northumbria...

Police warn of ‘dangerous drug batch’ after three deaths in the North East

Best drinks for blood sugar Worst drinks for blood sugar Other ways to balance blood sugar Why it's important for everyone. We carefully vet all products and services featured on mindbodygreen using our commerce guidelines. Our selections are never influenced by the commissions earned from our links. Your blood sugar...

4 Drinks That Will Keep Blood Sugar Low (And 2 That Will Spike It)

Community Voices represent independent, third-party users who have joined our contributor program but not yet verified their accounts. Community Voices are expected, like all users, to adhere to our Community Standards.

community_voice

Carol Perez

There are lots of places in the US where you don’t necessarily need a car. There might be good public transportation and/or your area might be walkable, but for others, this might not be the case.

Free Car Programs: 16 Ways to Get a Car Without Paying

Kratom, a drug sold at U.S. gas stations and on the internet, has some serious risks and has caused deaths. Kratom alkaloids differ from heroin as they have opioid plus serotonergic, adrenergic, and other effects. Scientists are trying to separate the constituents of Mitragyna speciosa Korth leaves to find new...

What We Know About Kratom

Landlords get a lot of flak for being unreasonable, hard to get a ahold of, and exploitative. And many of them are! But we don't often acknowledge that landlords are, in fact, taking a risk when they rent their property out to you. They often have good reason to require extensive background checks, reference checks, and expensive security deposits.

Landlord shows $10K of damage done by tenants in just 6 months

MadameNoire

Pulmonary edema is a critical condition where fluid accumulates in the lungs.

Recognizing Pulmonary Edema: Key Warning Signs To Watch For

One of the most consumed drugs in the US – and the most commonly taken analgesic worldwide – may do a lot more than simply take the edge off your headache. Acetaminophen, also known as paracetamol and sold widely under the brand names Tylenol and Panadol, may also increase risk-taking, according to a study from 2020 that measured changes in people's behavior when under the influence of the common over-the-counter medication.

The World's Most Common Pain Relief Drug May Induce Risky Behavior

Denver, CO

Contributors represent independent, third-party users who have joined our contributor program and self-verified their accounts. They have also demonstrated their experience writing hard news for other outlets. Contributors are expected, like all users, to adhere to our Community Standards.

contributor

David Heitz

A dangerous drug that is being mixed into fentanyl is causing those who inject it to develop a rash of sores that resembles a case of flesh-eating bacteria. People experiencing homelessness around Denver can sometimes be seen with these bloody, weeping wounds. I recently mentioned this phenomenon to a fentanyl user who told me about the xylazine connection.

Denver homeless people suffer sores as xylazine enters fentanyl supply

OX124 is a nasal spray provides rapid absorption of naloxone for patients experiencing an opioid overdose. The FDA would like to see additional technical data, as well as data on whether patients can correctly use the device. The FDA has issued a complete response letter for Orexo’s OX124. The product...

FDA Issues Complete Response for High-Dose Opioid Rescue Med

Coral Gables, FL

Writers represent independent, third-party users who have joined our contributor program and self-verified their accounts. Writers are expected, like all users, to adhere to our Community Standards.

writer

Edmond Thorne

Tragic End for South Florida Hispanic Building Tycoon Sergio Pino. Fort Lauderdale, FL - In a shocking turn of events, prominent South Florida homebuilder Sergio Pino was found dead in his Coral Gables home on Tuesday morning. The Miami-Dade County Medical Examiner's Office confirmed that Pino died from an apparent suicide.

South Florida Tycoon Dead After FBI Raids on Homes and Office

NewsBreak

Replacing Opioids: Natural Compound Promises Pain Relief Without Addiction

Researchers at Mainz University have discovered a natural compound that could potentially serve as a long-term alternative to opioids and may help alleviate the opioid crisis....

Replacing Opioids: Natural Compound Promises Pain Relief Without Addiction

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