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Researchers have discovered how a cell surface protein called Aplp1 can play a role in spreading material responsible for  Parkinson's disease from cell-to-cell in the brain.
Promisingly, an FDA-approved  cancer drug that targets another protein called Lag3 – which interacts with Aplp1 – blocks the spread in mice, suggesting a potential therapy may already exist.



					
			

In a new paper, an international team of scientists describes how the two proteins work together to help harmful alpha-synuclein protein clumps get into brain cells.
"Now that we know how Aplp1 and Lag3 interact, we have a new way of understanding how alpha-synuclein contributes to...

Parkinson's Discovery Suggests We May Already Have an FDA-Approved Treatment

A study reveals that brain inflammation leads to the release of a protein that impairs muscle function, suggesting potential treatments for related muscle fatigue in diseases like Alzheimer’s and long COVID. Infections and neurodegenerative diseases are known to cause brain inflammation. However, patients with brain inflammation often develop muscle...

Hidden Connection Discovered: New Research Links Brain Inflammation to Muscle Fatigue

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Parkinson’s disease is a progressive neurodegenerative disorder that affects millions of people worldwide. Characterized by tremors, stiffness, and difficulty with balance and coordination, the disease is primarily caused by the loss of dopamine-prod...

3 Supplements A Neuroscientist Swears By To Prevent Parkinson’s Disease: ‘Gives Your Brain The Raw Materials To Repair Itself’

Everybody poops sometimes, but does it really matter how often? Fiber-fermenting gut bacteria known as "strict anaerobes," associated with good health thrived in the "Goldilocks zone" of one or two poops a day.

One or two bowel movements a day keeps the doc away: study

A cross-sectional study found that static pain measures could be useful for predicting fatigue severity in patients with sickle cell disease (SCD). Evaluating the pain threshold of patients with sickle cell disease (SCD) proved to be a useful tool for predicting the severity of SCD-related fatigue. These findings hold the potential to expand personalized medicine in SCD, from treatment approaches to pain evaluations, according to a recent study published in Journal of Evaluation in Clinical Practice.1.

Pain Threshold Predictive of Fatigue Severity in SCD, Study Finds

Researchers at Mainz University have discovered a natural compound that could potentially serve as a long-term alternative to opioids and may help alleviate the opioid crisis. Opioids, recognized for their significant pharmacological effects, have long been used as effective painkillers. Morphine, a notable example first isolated and synthesized in the early 19th century, provides crucial relief for patients in the final stages of severe illness.

Replacing Opioids: Natural Compound Promises Pain Relief Without Addiction

Developed by Vertex Pharmaceuticals, suzetrigine is a promising new class of pain medicine that has been gaining attention for its innovative mechanism of action and reported efficacy; suzetrigine might offer hope for those struggling with acute pain issues who want to avoid opioids and NSAIDs. The reliance on opioids and...

A New Class of Medicine for Pain Relief On The Horizon

The 13-year-old boy, Oran Knowlson, was sometimes having hundreds of seizures per day before the device was fitted. A 13-year-old boy named Oran Knowlson has become the world’s first patient to test out a brain stimulation implant to treat severe epilepsy. Knowlson was sometimes having hundreds of seizures per...

Child Patient Receives World’s First Brain Implant For Rare Form Of Epilepsy

A new study has demonstrated that etripamil, a home-administered nasal spray, safely and effectively treats PSVT, a condition causing rapid heart rhythms, potentially minimizing hospital visits and invasive procedures. Investigators from Weill Cornell Medicine conducted a clinical trial that demonstrated a nasal spray could successfully and safely treat recurrent abnormal...

Clinical Trial Confirms: Nasal Spray Safely Treats Recurrent Abnormal Heart Rhythms

Verywell Health

A recent study found people with carpal tunnel syndrome tend to develop cardiac amyloidosis, also known as “stiff heart syndrome,” about 10 to 15 years later. Experts say the presence of carpal tunnel syndrome may be an early warning sign for cardiac amyloidosis, as amyloid deposits can affect both the wrist’s connective tissue and the heart.

Carpal Tunnel Syndrome May Triple Your Risk of Developing Stiff Heart Syndrome

Deep vein thrombosis (DVT) occurs when a blood clot forms in a deep vein, typically in the legs. Treating a DVT is crucial, as the clot can break loose from the affected vein, move through the bloodstream to the heart, and lodge itself within the lung's main artery. This complication—what's known as pulmonary embolism—can be fatal.

How to Dissolve Blood Clots in Legs

Understanding your bowel movements is crucial for maintaining overall health. Your colon, also known as the large intestine, plays a significant role in your digestive system. Constipation and other changes in bowel movements can be indicators of your colon’s health. In this article, we’ll explore what these signs mean and how you can maintain a healthy colon.

What constipation and bowel movements tell you about your colon

Community Voices represent independent, third-party users who have joined our contributor program but not yet verified their accounts. Community Voices are expected, like all users, to adhere to our Community Standards.

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Emily Standley Allard

We often run across people in our lives who either have a natural healing and calming energy to them and those who seem bent on ruining everything you set out to do whether they mean to or not. Astrology offers a complex and nuanced understanding of personality traits associated with each zodiac sign, attributing both positive and negative aspects to individuals' characters. Among these characteristics, some signs are often hailed for their healing abilities, bringing comfort, peace, and rejuvenation to those around them. Conversely, other signs may possess more destructive tendencies, challenging relationships and personal growth. This article explores the zodiac signs that are traditionally considered the most healing and the most destructive, offering insights into the dual nature of certain astrological influences.

The 6 Zodiac Signs That Can Either Heal or Destroy You

Symptoms of carpal tunnel syndrome (CTS) and tendonitis can overlap. It is important to distinguish between the two to receive appropriate treatment. CTS occurs when tissues swell and compress the median nerve, the main nerve from the forearm to the hand. This can be due to multiple factors, including repetitive...

What is the difference between carpal tunnel syndrome and tendonitis?

HuffPost

Here are our readers’ top picks when it comes to getting pain relief.

The Greatest Pain Relief Tools Of All Time, According To HuffPost Readers

Osteoarthritis progresses through stages 1 to 4, each with its own set of symptoms, diagnostic challenges, and treatment options. form of arthritis, affecting millions of people worldwide. It occurs when the protective cartilage that cushions the ends of the bones wears down over time. Although OA can damage any joint, the disorder.

The four stages of osteoarthritis

A special issue of the Journal of the Academy of Nutrition and Dietetics on chrononutrition clarifies the science behind the effectiveness of fasting regimes. Recent research explores how aligning meal times with our biological clocks can improve health, focusing on intermittent fasting’s role in weight management and metabolic health without the need for calorie counting.

What Time Do You Eat? Recent Research Reveals That It Can Impact Your Overall Health

Scientists have developed new biosensors that enable real-time tracking of opioid signaling in the brain, offering profound insights into the effects of opioids and enhancing the development of targeted therapeutics. New findings from a researcher at the Max Planck Florida Institute for Neuroscience could revolutionize our understanding of how opioids...

Revolutionary Opioid Research Could Transform Addiction Treatment

German researchers have created a catalyst that converts ammonia into hydrogen and nitrite, potentially combining hydrogen production and fertilizer creation in one process. A research team from the University Alliance Ruhr in Germany has discovered a catalyst capable of converting ammonia into both hydrogen, an energy carrier, and nitrite, a precursor for fertilizer. Traditionally, the production of hydrogen and fertilizer has involved separate chemical processes.

“This Had Never Been Done Before” – New Dual-Use Catalyst Overcomes the Thermodynamic Canyon

Virginia State

Writers represent independent, third-party users who have joined our contributor program and self-verified their accounts. Writers are expected, like all users, to adhere to our Community Standards.

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Cheryl E Preston

The scenes between General Hospital cast members Eden McCoy (Joss Jacks) and Evan Hofer ( Dex Heller) are filled with so much chemistry that some fans believed the couple was dating offscreen.

General Hospital's Eden McCoy is dating actor Jonathan Heit and not her onscreen love Evan Hofer

NewsBreak

The Missing Piece in Chronic Pain Puzzle? Novel Protein Function Discovered

Researchers in Gary Lewin’s lab at the Max Delbrück Center have pinpointed an ion channel that plays a role in chronic pain, offering a new potential...

The Missing Piece in Chronic Pain Puzzle? Novel Protein Function Discovered

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