Columbus, OH

This randomized, placebo-controlled, phase 3 clinical trial showed that a 14-day treatment course of oral zuranolone 50 mg/day in MDD led to significantly greater improvements in depressive symptoms when compared with placebo. TRANSLATING RESEARCH INTO PRACTICE. Rajesh R. Tampi, MD, MS, DFAPA, DFAAGP, Column Editor. A monthly column dedicated to...

Zuranolone for the Treatment of Adults With Major Depressive Disorder

New research found that among 8 first-line antidepressants, bupropion was associated with the least weight gain most consistently. In a target trial emulations study, investigators found small differences in mean weight change between 8 first-line antidepressants; bupropion consistently showed the least weight gain, but medication adherence over follow-up was low.1,2.

Which Antidepressant Causes the Least Amount of Weight Gain?

In this study, 49.5 percent of participants had taken a benzodiazepine at some point over the past 15 years. After a follow-up interval averaging 11.2 years, 13.3 percent had developed dementia. The researchers conclude, “Overall use of benzodiazepines is not associated with increased dementia risk.”. They also find, separately,...

Long-Term Use of Benzodiazepines and Dementia Risk

People with an irregular heart rhythm taking a common blood pressure drug may be at greater risk of serious bleeding, according to a study recently published in JAMA. Atrial fibrillation is the most common type of irregular heart rhythm and can lead to blood clots or stroke if left untreated, according to the American Heart Association.

Common Blood Pressure Drug May Increase Bleeding Risk for Some Patients, Study Finds

Muscle relaxers are prescription medications that are often used to treat discomfort associated with muscle spasms, strains, and other muscle and skeletal conditions. However, they are not considered first-line therapies for these conditions and are generally not intended for long-term use. Tizanidine and cyclobenzaprine are two commonly used muscle relaxers....

How Do the Muscle Relaxers Tizanidine and Cyclobenzaprine Differ?

CBS News

New research is comparing the weight changes of patients taking different types of antidepressants, one of the most commonly prescribed medications in the United States.The study, published on Tuesday in the Annals of Internal Medicine, analyzed the data of 183,118 patients across 8 U.S. health systems from 2010 to 2019. It found that some antidepressants were associated with more weight gain than others.At six months, users of escitalopram (which is sold under the brand name Lexapro), paroxetine (Paxil) and duloxetine (Cymbalta) were 10% to 15% more likely to gain at least 5% of their baseline weight than sertraline (Zoloft) users. Bupropion...

Patients on these antidepressants were more likely to gain weight, study says

Specializes in Public Health, TB. You listen to their concerns, and clarify what they believe the consequences are. Then, you can educate about why the patient is prescribed opioids, what are the alternatives, and what the actual adverse effects and risks are. 1,996 Posts. Specializes in Mental Health, Gerontology, Palliative.

How to respond to opoid addiction?

ScienceAlert

One of the most consumed drugs in the US – and the most commonly taken analgesic worldwide – may do a lot more than simply take the edge off your headache. Acetaminophen, also known as paracetamol and sold widely under the brand names Tylenol and Panadol, may also increase risk-taking, according to a study from 2020 that measured changes in people's behavior when under the influence of the common over-the-counter medication.

The World's Most Common Pain Relief Drug May Induce Risky Behavior

Antidepressants are a common group of medications that help treat several mental health conditions. Doctors need to consider potential side effects when prescribing specific antidepressants. A recent study highlighted the weight changes associated with several antidepressants. Buproprion was associated with the least amount of weight gain, while antidepressants like escitalopram...

Study pinpoints 3 common antidepressants tied to the most weight gain

LETM and AQP4-IgG seropositivity were strong predictors of spinal movement disorders, while MOG-IgG and African American race are protective factors. Recently published data from a prospective observational study revealed that spinal-generated movement disorders are highly prevalent in non-multiple sclerosis (MS) demyelinating disorders of the spinal cord and their prevalence rates were much higher than the rates reported in MS. Overall, the prevalence was highest in aquaporin-4-positive neuromyelitis optica spectrum disorder (AQP4+ NMOSD) and lowest in myelin oligodendrocyte glycoprotein antibody disorder (MOGAD).

Spinal Movement Disorders Prevalent in Non-MS Demyelinating Disorders of Spinal Cord

A recent study published in the journal Translational Psychiatry has uncovered that a single dose of a common antidepressant, specifically a selective serotonin reuptake inhibitor, can change how the brain processes internal bodily sensations. This effect is particularly evident when individuals are anxious, revealing a nuanced interaction between serotonin, interoception (the sensing of internal bodily states), and anxiety.

Antidepressants affect how the brain processes internal sensations, study finds

HealthDay News — For patients presenting with acute pain, the quantity of opioids consumed during 2 weeks after emergency department discharge is low and varies across pain conditions, according to a study published online in CMAJ, the journal of the Canadian Medical Association. Raoul Daoust, MD, from Sacré-Coeur Hospital...

Low Quantity of Opioids Used After ED Discharge for Acute Pain

Denver, CO

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David Heitz

A dangerous drug that is being mixed into fentanyl is causing those who inject it to develop a rash of sores that resembles a case of flesh-eating bacteria. People experiencing homelessness around Denver can sometimes be seen with these bloody, weeping wounds. I recently mentioned this phenomenon to a fentanyl user who told me about the xylazine connection.

Denver homeless people suffer sores as xylazine enters fentanyl supply

Manchester, NH

InDepthNH.org

Manchester man faces multiple assault charges in connection with a 2-month old baby. On July 7, at approximately 3 p.m. an unresponsive baby boy was brought to Elliot Hospital.

Man Accused of Assaulting Infant

California State

The HD Post

CALIFORNIA – Starting July 1, landlords will only be allowed to collect one month’s rent for the security deposit on a rental property. Assembly Bill 12, signed into law last October, says regardless of whether the residential property is unfurnished or furnished, only one month’s rent can be charged in addition to any rent for the first month paid on or before initial occupancy.

Law limiting security deposits goes into effect July 1

Pancreatic cancer can cause back pain that spreads from the abdomen. It often affects the middle of the back and may feel like a dull ache. For some people, the pain may come and go. Pancreatic cancer causes different symptoms, including back pain. Back pain can have many possible causes,...

What to know about pancreatic cancer and back pain

Visual hallucinations are a significant issue for many patients with Parkinson’s disease. A recent study published in the journal Brain reveals that these hallucinations are associated with a marked deficiency of cholinergic activity in specific regions of the brain, particularly the left ventral visual stream and the left superior temporal lobe. This research highlights the importance of cholinergic denervation in visual hallucinations, offering new insights into the underlying mechanisms and potential treatment options.

Visual hallucinations in Parkinson’s disease linked to cholinergic deficiency

North Carolina State

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Town Talks

Death Disclosure Laws and Property Disclosures in North Carolina. In North Carolina, there is no legal obligation for homeowners or real estate agents to disclose if a death has occurred in a home, whether by natural causes, murder, or suicide. However, if a potential buyer directly inquires about any deaths on the property, the seller is required to provide that information.

If someone dies at your house do you have to tell a potential buyer? What North Carolina law says

Chicago, IL

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Foodie in Chicago

Shortly before 3 AM, people in the Chicago area may have felt their houses shake as a 3.4-magnitude earthquake occurred about 60 miles west of the city. (CHICAGO) The United States Geological Survey (USGS) reported a 3.4-magnitude earthquake around Somonauk, IL. Somonauk is in DeKalb and LaSalle Counties, 64 miles west of Chicago.

Did You Feel the Earthquake?

Massachusetts State

Dianna Carney

Hammy and Cheyanne, two miniature poodles, are in search of their forever home. Weighing 6.3lb and 6.4lb respectively, these sweet pups are a bonded pair with a sad past. Sandy Paws Rescue Inc., a foster-based rescue in Massachusetts, shares their story, explaining that "Hammy & Cheyanne are cruelty case pups that are a bonded pair. They're from a rural area in Texas. These are a pair of sweet little pups that are in need of a fresh start together!"

Meet The Sweet Little Dogs Who Are Looking For Love

NewsBreak

Taking Both CYP2D6 Opioids and Antidepressants Leads to Risk for Older Adults

A study shows it is safer for nursing home residents on CYP2D6 opioids to take CYP2D6-neutral antidepressants than CYP2D6-inhibiting antidepressants. The concomitant use of CYP2D6-metabolized opioids...

Taking Both CYP2D6 Opioids and Antidepressants Leads to Risk for Older Adults

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