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15 Best Serums for Mature Skin, According to Celebrity Dermatologists
By Laura Beck,
17 hours ago
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Let's face it: getting older is has its ups and downs, and our skin is along for every bump in the road. But fear not! We've got the inside track on the secret weapons to keep your skin looking as young as you feel. We've rounded up the crème de la crème of facial skin serums—the best serums for aging skin —handpicked by top dermatologists who know their stuff.
Before you dive into this treasure trove of skin-loving goodness, remember: your skin is as unique as your Netflix watchlist. Some of us might be Bridgerton devotees, while others of us can’t stop binging Baby Reindeer . This is all to say: some of these anti-aging serums will be great for your skin, but it's always a good idea to have a chat with your derm to find your perfect match.
Here are the 15 best face serums that'll have your mature skin feeling plump and looking pretty—including picks with vitamin C, hyaluronic acid and more.
When it comes to mature skin, it's not just about slapping on any old serum and hoping for the best. Dr. Blair Murphy-Rose , a board-certified celebrity dermatologist and founder of Skincare Junkie , breaks it down for us. She explains that women over 50 often grapple with "fine lines and wrinkles, laxity, hyperpigmentation and dryness." But don't worry, there's hope in a bottle.
Dr. Murphy-Rose recommends serums packed with powerhouse ingredients like retinol, antioxidants, hyaluronic acid, vitamin C, tranexamic acid and kojic acid. For fine lines and saggy bits, she suggests collagen boosters such as retinol and antioxidants like coenzyme Q10, resveratrol, vitamin C and green tea. Hyaluronic acid is your go-to for plumping up the skin.
If you're battling the dreaded dark spots, Dr. Murphy-Rose has a solution for that too. Look for serums containing tranexamic acid, cetyl tranexamate mesylate, kojic acid, vitamin C, and niacinamide. And for those of us with skin drier than a desert, hyaluronic acid and other humectants are your new best friends.
Celebrity dermatologist Dr. Nicole Lee , owner of Epoch Dermatology , is a fan of hydrating serums with gentle AHA/BHA formulations. "I recommend looking for hyaluronic acid and niacinamide based serums with healing properties, repairing the skin barrier and reducing inflammation in the skin," she says. It's like a soothing balm for your face after a long day of, well, being a face.
How Do You Use Serum in Your Morning Skincare Routine?
Now, let's talk about the when and how of serum application. It's not rocket science, but there's an art to it.
For your morning routine, Dr. Murphy-Rose keeps it simple and sweet. After you've given your face a proper cleanse, you apply a few drops of serum followed by moisturizer and sunscreen. Of course, if your serum has SPF in it, that can cut down on a step.
Dr. Lee adds that you can use serums to target specific problem areas and then layer on moisturizer and SPF.
How Do You Use Serum in Your Evening Skincare Routine?
When it comes to your evening routine, it's not much different. Dr. Murphy-Rose keeps it straightforward: "After cleansing in the evening, pat dry then apply your serum followed by a moisturizer and under eye cream."
Dr. Lee echoes this sentiment, adding a bit of skincare wisdom: "Using serums in the evening is very similar to using them in the morning. Due to their lightweight nature, it is recommended to apply serums first, followed by heavier creams or thicker based products." Think of it as building a pyramid—lightest at the top, heaviest at the base.
The key is consistency and finding what works best for your unique skin.
Dr. Murphy-Rose says: "It combines antioxidant, anti-pollution, and anti-aging benefits into a silky lightweight moisturizer that won't clog pores. It is like a serum and moisturizer all-in-one! The clinically proven blend of coenzyme Q10, resveratrol, green tea and vitamin C protects against skin aging and supports collagen while ceramides and hyaluronic acid in a 7 molecular weight blend hydrate and plump."
Dr. Lee recommends this serum, noting it has "very few ingredients, transparent on the products used, backed by science for technology that works with an elegant and simple, clear formulation for effective delivery."
Formulated with 5 molecular weights of hyaluronic acid, this serum provides immediate hydration and energizes skin cells, and it's one of the experts' top picks. Shoppers agree.
“This skin care is magic!” says customer Dena E . “I cannot express how soft my skin is. I am 58 years old and have a nice skincare routine using high-end products. I got some ‘Try Me’ samples of the Thursty Skin and WOW. My skin feels alive, hydrated, and so smooth, even my makeup goes on smoother.”
“It is a good choice for sensitive skin containing a moderate concentration of ascorbic acid and, bonus, it is a more budget-friendly vitamin C,” shares Dr. Murphy-Rose.
"It is well-known for its potent serum containing vitamin C, E and ferulic acid to boost collagen and protect from free radical damage,” says Dr. Murphy-Rose. “This is a great serum for those with mature skin."
Formulated with retinol and hydrating ingredients, this serum addresses signs of aging while providing intense moisture for dry, mature skin.
Customer Audrina P.'s says , “Pain free! I have used other rentinols in the past and they make my face red and dry! This RXR retinol doesn't iterate my skin at all and I use it everyday."
Dr. Murphy-Rose says: "This serum blends a variety of peptides with copper peptides to boost collagen production, improve elasticity, and diminish the appearance of wrinkles. Additionally, hyaluronic acid provides deep hydration."
This serum combines Retinol, Vitamin C, and Azelaic Acid to target multiple signs of aging. Customer Kristin T. says , “Such an easy product to use and made my skin feel so incredibly soft/firm, but more importantly, not so tired – my skiing looked bright and healthy and felt great!”
Dr. Murphy-Rose explains: "This innovative solid serum instantly turns from solid to fast-absorbing serum allowing targeted treatment to the areas you want to treat and avoiding lightening surrounding skin. It addresses sun damage, post-acne marks, melasma and more with delivery of a proprietary powerhouse combination of clinically-proven kojic acid, tranexamic acid and vitamin C in their most penetrable, potent, and yet well-tolerated forms."
Not only do the experts love it, but customer Jorie A calls it a “holy grail” item, and says, “I am obsessed with this serum! I was looking to simplify both my AM and PM routines, and this serum is now the only step before moisturizing. My skin has felt SO good over the last three weeks since I started using it.”
This anti-aging serum is powered by a unique Epidermal Growth Factor (53) made up of 53 amino acids that restore moisture and recondition the skin overnight.
Customer Mona A. says , “As a makeup artist for over 8 years and a daily makeup user, I'm always looking for new and good products to use and recommend. Right off the bat I loved this serum. It's a milky yet lightweight texture that absorbed beautifully into my skin.”
This serum combines the power of Vitamin C with SPF protection, offering both anti-aging benefits and sun defense in one product. Customer Vanita Prakash says it’s “so silky it glides and makes the sunscreen experience so much nicer!”
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