Which Weight Loss Drug Has the Best Results? New Study Reveals Mounjaro Is More Effective Than Ozempic

If you’re looking for the most effective weight loss drug, you may want to put Ozempic on the back burner. A new study revealed that Mounjaro actually led people to the most weight loss. While both drugs have proven to aid in shedding those extra pounds, Mounjaro has come out on top. Keep reading to find out more about each drug, the study and its results and what experts have to say about these methods.

Mounjaro is more effective for weight loss

In a study published July 8 in the journal JAMA Internal Medicine , it was revealed that Mounjaro and Zepbound led to more weight loss than Ozempic and Wegovy. The reason for this is that tirzepatide, the ingredient found in the former, brings out more results than semaglutide, the ingredient in the latter.

The results found that patients taking tirzepatide over a yearlong span were much likelier to achieve a weight loss of 10 percent or higher compared to those taking semaglitude. After the year was up, the patients on tirzepatide lost up to 15 percent of their body weight while the other group on Ozempic or Wegovy only lost eight percent.

Check-ins took place at three, six and 12 months and across the board, the total amount of weight lost was higher among those taking tirzepatide. “The mean on-treatment change in body weight was −5.9 percent for tirzepatide vs −3.6 percent for semaglutide at three months, −10.1 percent vs −5.8 percent at six months and −15.3 percent vs −8.3 percent at 12 months,” per the study.

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How was the data collected?

Researchers at Truveta, a healthcare data and analytics company investigated electronic records and prescriber data. They identified adults who were overweight or obese and began taking Mounjaro or Ozempic for the first time between May 2022 and September 2023. Those in the study could not have been prescribed one of these drugs before taking part.

It didn’t matter if participants had type 2 diabetes or not, although half of them were living with (T2D) and were considered for their weight. Forty thousand patients met the criteria for the study, but after matching up individuals with similar characteristics on tirzepatide or semaglitude, the remaining group was down to 18,386. Most of the participants were white females and the average age of all participants was 52.

This is the first study where the two drugs were compared head-to-head in a real-world setting with healthcare data. They’re both used for diabetes but have been used more recently for weight loss.

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What are the differences between Mounjaro and Ozempic?

Sharon Giese, MD, creator of the Elective Weight Loss (EWL™) Program , who’s based in New York views “Mounjaro as the ‘big guns’ because it acts on two receptors, where semaglutide acts on one.” Tirzepatide acts on both GLP-1 (glucagon-like peptide) and GIP receptors, enhancing insulin secretion and reducing appetite more effectively while semaglutide primarily targets GLP-1 receptors.

She adds that if someone were relatively healthy and only overweight versus obese, she would advise them to start on semaglutide because it’s a slower-performing drug. Both are in the same class and have proven to be the most effective of the weight loss drugs.

Keep reading for more weight loss medication insight:

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A New Ozempic Pill? Roche Shakes Up the Weight Loss Drug Market With Promising Results: See The Data

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This content is not a substitute for professional medical advice or diagnosis. Always consult your physician before pursuing any treatment plan .