The Conversation UK

Scientists in America have developed a nasal spray that can remove proteins in the brain associated with Alzheimer’s disease – at least, in mice. There are two proteins implicated in Alzheimer’s: amyloid and tau. Most of the drugs – included those recently approved by the US Food and Drug Administration (FDA) – focus on removing amyloid. To date, though, there has been little focus on removing tau “tangles”. However, the new nasal spray, developed by researchers at the University of Texas Medical Branch, focuses on this protein.

Nasal spray clears proteins linked to Alzheimer’s – new study

BGR.com

A group of Chinese researchers has created a robot with a brain made of human stem cells. The technology is technically a “brain-on-a-chip,” and the researchers have been working to train the robot to perform various tasks. The stem cell brain that powers the robot is attached to a neural interface chip, which powers the entire thing.
Tianjin University, one of the two institutes behind the new research, considers the design the world’s first open-source brain-on-chip system and says that it could lead to the development of more brain-like computing. The key to the entire design is an in-vitro cultured brain...

Terrifying new robot has a brain made from human stem cells

shefinds

Parkinson’s disease is a progressive neurodegenerative disorder that affects millions of people worldwide. Characterized by tremors, stiffness, and difficulty with balance and coordination, the disease is primarily caused by the loss of dopamine-prod...

3 Supplements A Neuroscientist Swears By To Prevent Parkinson’s Disease: ‘Gives Your Brain The Raw Materials To Repair Itself’

Visual hallucinations are a significant issue for many patients with Parkinson’s disease. A recent study published in the journal Brain reveals that these hallucinations are associated with a marked deficiency of cholinergic activity in specific regions of the brain, particularly the left ventral visual stream and the left superior temporal lobe. This research highlights the importance of cholinergic denervation in visual hallucinations, offering new insights into the underlying mechanisms and potential treatment options.

Visual hallucinations in Parkinson’s disease linked to cholinergic deficiency

Summary: A new experimental cancer drug could ease cognitive difficulties for those with Rett syndrome, a rare autism-linked disorder, by enhancing brain cell functions. The drug, ADH-503, improves the activity of microglia, which are crucial for maintaining neural networks. Researchers found that healthy microglia restored synapse function in brain organoids...

Cancer Drug Shows Promise for Autism Cognitive Function

SurvivorNet

A woman diagnosed with advanced triple-negative breast cancer in 2012 had already seen several treatment options fail, leaving her doctors to give her a year left to live. However, she found hope in a clinical trial that used an immunotherapy treatment that allowed her to live “cancer-free” 12 years after her diagnosis.

Charlotte Mom, 49, Saved By Experimental Life Saving Medicine, Thriving 12-Years Later: Guide To Accessing Clinical Trials

San Diego, CA

An unusually large brain may be the first sign of autism — and visible as early as the first trimester, according to a recent study conducted by UCSD. Some children with profound autism face lifelong challenges with social, language, and cognitive skills, including the inability to speak. In contrast, others exhibit milder symptoms that may improve over time.

Scientists Have Uncovered Autism’s Earliest Biological Signs

Chronic lymphocytic leukemia (CLL) is a type of cancer affecting a type of white blood cell in the blood and bone marrow. It often progresses slowly and is diagnosed most often during routine blood testing. Understanding the stages of CLL—from stage 0 to 4—can help you navigate a CLL diagnosis....

Stages of Chronic Lymphocytic Leukemia (CLL)

The study is expected to evaluate the safety of Iomab-ACT in sickle cell disease patients who are undergoing allogeneic bone marrow transplants. The FDA has cleared Actnium Pharmaceuticals’ Investigational New Drug (IND) application to study Iomab-ACT, a targeted radiotherapy conditioning agent, developed in a partnership with Columbia University for the treatment of patients with sickle cell disease (SCD) who are undergoing allogeneic bone marrow transplants (BMT). The study, which will be led by Markus Mapara, MD, PhD, professor of medicine, Colombia University Irving Medical Center, director, Bone Marrow Transplantation and Cell Therapy Program, Vagelos College of Physicians and Surgeons, will evaluate the safety of Iomab-ACT in this patient population.1.

FDA Clears Investigational New Drug Application for Actinium Pharmaceuticals’ Iomab-ACT in Patients with Sickle Cell Disease

A second dendritic cell vaccine has received fast track designation from the Food and Drug Administration. The Food and Drug Administration (FDA) has granted a fast track designation to a dendritic cell vaccine for the treatment of patients with pancreatic ductal adenocarcinoma. Immuno-oncology company Diakonos Oncology Corporation announced the designation...

FDA Fast Tracks Pancreatic Cancer Vaccine

The Food and Drug Administration has given the go-ahead for a late-stage clinical trial of an injectable stem cell product that could give new hope to millions of patients suffering from lower back pain caused by degenerative disc disease (DDD). Up to 400 patients with mild to moderate DDD are expected to enroll in the Phase 3 study later this year.

FDA Approves Stem Cell Study for Degenerative Disc Disease

A machine-learning study at Weill Cornell Medicine was able to classify Parkinson’s disease into three subgroups, a development with the potential to effectively target patients with treatments specific to their disease’s progression. By analyzing data from an existing study, researchers split the cohort into Rapid Pace, Inching Pace,...

Parkinson's disease could have 3 subtypes, researchers find

New York City, NY

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Cheryl E Preston

Yesterday was the third time this year that an ad stating Chelsea Clinton lives in a beautiful Virginia home popped up on my laptop. My computer did not warn me this was a dangerous site, so this time, I clicked on the link.

Chelsea Clinton is rumored to be living in Virginia but probably still in NYC

When it comes to treating non-Hodgkin lymphoma, bispecific antibodies are a unique targeted therapy that essentially attack cancer on two fronts — and recent approvals mean more patients have access.

Bispecific Antibodies for Lymphoma: What Does the Future Look Like for the Promising Targeted Therapy?

Boehringer Ingelheim announced Monday that it has acquired Nerio Therapeutics and its preclinical program of novel immune checkpoint inhibitors for up to $1.3 billion to expand its immuno-oncology portfolio. Under the deal, Boehringer gains access to Nerio’s small molecules designed to inhibit the protein tyrosine phosphatases N1 and N2 (PTPN1...

Boehringer Buys Nerio Therapeutics for $1.3B to Boost Immuno-Oncology Pipeline

Two recent developments in Alzheimer’s disease research offer new hope for patients living with the disease, and their families. Among those, in June, Tiziana Life Sciences received Food and Drug Administration clearance to use intranasal foralumab in its first patient with moderate Alzheimer’s disease under the FDA’s expanded access investigational new drug program.

FDA clears nasal spray for moderate Alzheimer’s disease in first patient

Denver, CO

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David Heitz

A dangerous drug that is being mixed into fentanyl is causing those who inject it to develop a rash of sores that resembles a case of flesh-eating bacteria. People experiencing homelessness around Denver can sometimes be seen with these bloody, weeping wounds. I recently mentioned this phenomenon to a fentanyl user who told me about the xylazine connection.

Denver homeless people suffer sores as xylazine enters fentanyl supply

TheDailyBeast

A groundbreaking new blood test announced this week is capable of diagnosing Alzheimer’s disease with 91 percent accuracy—opening the way to routine testing for the condition, similar to that for cholesterol or prostate cancer.The breakthrough, unveiled by Swedish researchers at the Alzheimer’s Association International Conference in Philadelphia and published in JAMA, revealed that the new blood tests are far more accurate than family doctors and even specialists.Traditionally, Alzheimer’s diagnosis has depended on a specialist making a finding followed by more invasive methods like spinal taps and brain scans.But the study used new tests measuring the presence of a biomarker called...

New Blood Test for Alzheimer’s Is 91% Accurate, Study Finds

Multiple sclerosis (MS) is a disease that damages the nerves of the central nervous system. This damage disrupts nerve impulses and can lead to ataxia — a condition that affects coordination, balance, and speech. This article outlines the symptoms of ataxia. It also considers the prevalence of this condition...

What to know about ataxia in multiple sclerosis

South Carolina State

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Explore Beaufort SC

The mantis shrimp is one tough customer. Beautiful and deadly are two words you don’t typically use to describe shrimp, but the mantis shrimp is definitely in a class of its own; earning a reputation as the ‘savage boxer of the sea’ and one of the most fearsome creatures in the ocean. And, they're right at home here in South Carolina.

Savage Boxer of the Sea: The Deadly Beauty of Mantis Shrimp

NewsBreak

Rapid Stem Cell Model Advances Parkinson’s Research

Summary: Researchers have developed a model that quickly converts stem cells to brain cells with Parkinson’s disease (PD) protein structures, allowing for personalized study and treatment....

Rapid Stem Cell Model Advances Parkinson’s Research

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