Worried About ‘Ozempic Face’? What an MD Wants You to Know about Ozempic Side Effects

Chances are, you know someone who’s lost weight with Ozempic. While this injectable medication was originally developed to treat diabetes, it’s often prescribed “off label” for weight loss. And there’s no denying that the results can be dramatic. But you may be worried about the potential for Ozempic side effects, especially after recent reports that dozens of patients taking Ozempic (and similar medications like Wegovy and Mounjaro) have filed lawsuits after suffering serious gastrointestinal injuries.

“While popular ‘band-aid’ solutions like Ozempic may seem like an easy fix, they often come with unwanted side effects,” says Markyia Nichols, MD , Chief Medical Officer at Ciba Health . Here are some of the biggest complaints when it comes to Ozempic side effects.

The 5 most common Ozempic side effects

If you're considering taking Ozempic, it's important to be aware of these potential side effects:

1. Gastrointestinal issues

Tummy troubles are the most common side effects of Ozempic. Many people experience unpleasant GI issues like bloating , nausea or diarrhea while taking semaglutide (the active ingredient in Ozempic).

“Semaglutides slow down the digestive process, which leaves people feeling full for longer — but, yes, also creates digestive side effects,” Dr. Nichols says. There are a few things you can do to help sidestep these symptoms:

• Start at a lower dose. “It will give your body a way to ‘warm up’ to the drug and to the changes in your body,” Dr. Nichols says.
• Adjust your eating habits. “Consider eating at a slower pace, consuming smaller meals, avoiding ultra-processed foods and staying hydrated,” Dr. Nichols says.
• Walk after meals. Walking after eating can aid digestion and help stave off unsavory symptoms. “Even a five-minute walk can help ease any forthcoming digestive issues,” Dr. Nichols advises.

In rarer cases, Ozempic may cause more serious gastrointestinal problems. Some patients have filed lawsuits against the manufacturers of medications like Ozempic, Wegovy and Mounjaro after developing severe side effects like gastroparesis (stomach paralysis), persistent vomiting or intestinal obstruction.

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2. 'Ozempic face'

Another common complaint among Ozempic users is that the rapid weight loss can cause sagging skin, which can be especially noticeable in the face. “‘Ozempic face’ refers to the effect that significant and rapid weight loss has on the face, such as a hollowed-out appearance, loose skin and more lines and wrinkles,” Dr. Nichols says.

This can be managed by staying hydrated and making sure you hit your protein goals for the day. The recommended daily intake of protein is 0.8 grams per kilogram of body weight. The quickest way to find that number: Multiple your weight in pounds by 0.36. For example, a 165-lb woman should aim for at least 59 grams of protein per day.

“Keeping the epidermis hydrated helps with skin repair and can minimize dryness and the appearance of wrinkles and lines,” Dr. Nichols says. “Getting enough protein supports collagen production, which is helpful for the skin’s cellular structure. It can also boost the strength and elasticity of skin.”

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3. Hypoglycemia

Low blood sugar is a possible Ozempic side effect. It’s rare, and it typically only happens if someone takes a counterfeit version or combines Ozempic with another diabetes medication. Still, it’s advisable to keep an eye on your blood sugar while taking Ozempic. “This can be done using a finger stick or continuous glucose monitor (CGM) and by getting your HbA1c checked regularly,” Dr. Nichols says.

4. Thyroid tumors

This may be the most daunting of the Ozempic side effects, but it’s still up for debate. In rodent studies, researchers found a link between semaglutide and certain types of thyroid tumors, which prompted a “black box” warning on the product label. But so far, human studies haven’t found the same risk. Most recently, a review of studies in International Journal of Molecular Science found that the risk to humans was negligible. However, you still may want to discuss the potential risks with your doctor, especially if you have any existing thyroid issues.

Worried about Ozempic side effects? There are natural options

Of course, if any of these Ozempic side effects have you feeling hesitant, you have other options. Ozempic works by mimicking GLP-1 , a hormone that helps to boost insulin production and manage blood sugar, which can help keep your appetite in check. But certain dietary changes may yield similar results.

“Ozempic isn't the only way to regulate GLP-1 levels,” Dr. Nichols says. “Thankfully, the foods we eat can have a positive effect, too.” She recommends supporting your metabolic health with a diet rich in healthy fats, lean protein, calcium, soluble fiber, fruits, veggies and legumes.

“Supplements that appear to help GLP-1 naturally include psyllium, curcumin and yerba mate,” she adds. “The point is, you don't necessarily need to take prescription medication such as Ozempic as a first stop for significant and lasting weight loss.”

For more on the pros and cons of injectables like Ozempic:

Which Weight Loss Drug Has the Best Results? New Study Reveals Mounjaro Is More Effective Than Ozempic

Could Ozempic and Other Weight Loss Drugs Reduce Bone Density? New Study Shows What Can Help

Ozempic Can Be a Sneaky Cause of Hair Loss — Dermatologists Reveal How To Restore Volume

This content is not a substitute for professional medical advice or diagnosis. Always consult your physician before pursuing any treatment plan.